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Microbial metabolism in diverse environments

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
5-hydroxyisourate + H2O <=> 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate 3.5.2.17 hydroxyisourate hydrolase
–
salicylate + NADPH + H+ + O2 <=> 2,5-Dihydroxybenzoate + NADP+ + H2O 1.14.13.172 salicylate 5-hydroxylase
–
H+ + vetrazine + H2O <=> N-Cyclopropylammeline + NH3 3.5.4
–
NO + H2O + ferricytochrome_c <=> nitrite + ferricytochrome_c + 2 H+ 1.7.2.1 nitrite reductase (NO-forming)
1.7.2.6 hydroxylamine dehydrogenase
–
–
3-(2,3-dihydroxyphenyl)propanoate + O2 <=> H+ + (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate 1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase
–
(S)-allantoin + H2O <=> H+ + Allantoate 3.5.2.5 allantoinase
–
7-Oxoheptanoic_acid <=> 7-Mercaptoheptanoic_acid not assigned
 –
(S)-Mandelate + FMN <=> benzoylformate + FMNH2 1.1.99.31 (S)-mandelate dehydrogenase
–
H2O + 4-Fumarylacetoacetate <=> H+ + fumarate + acetoacetate 3.7.1.2 fumarylacetoacetase
–
3-hydroxyphenylacetate + NADPH + O2 + H+ <=> homogentisate + NADP+ + H2O 1.14.13.63 3-hydroxyphenylacetate 6-hydroxylase
–
D-erythrose_4-phosphate + D-xylulose_5-phosphate <=> beta-D-fructose_6-phosphate + D-glyceraldehyde_3-phosphate 2.2.1.1 transketolase
2.2.1.3 formaldehyde transketolase
–
–
1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ <=> 3-methylcatechol + CO2 + NADH + H+ 1.3.1
–
H+ + o-Cresol + NADH + O2 <=> 3-methylcatechol + NAD+ + H2O 1.14.13.236 toluene 4-monooxygenase
1.14.13.243 toluene 2-monooxygenase
1.14.13.44 2-hydroxybiphenyl 3-monooxygenase
1.14.13.7 phenol 2-monooxygenase (NADPH)
–
–
–
–
4-hydroxy-3-methylbenzoate <=> 4-Hydroxyisophthalate not assigned
 –
oxaloacetate + ITP <=> CO2 + phosphoenolpyruvate + IDP 4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)
4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)
–
–
(3S)-3-carboxy-3-hydroxypropanoyl-CoA <=> glyoxylate + acetyl-CoA 4.1.3.24 malyl-CoA lyase
–
3-chloro-2-methyl-dienelactone + H2O <=> 3-chloro-2-methylmaleylacetate + H+ 3.1.1.45 carboxymethylenebutenolidase
–
ATP + L-rhamnulose <=> ADP + L-rhamnulose_1-phosphate 2.7.1.5 rhamnulokinase
–
cholesterol + NAD+ <=> cholest-4-en-3-one + NADH + H+ 1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
5.3.3.1 steroid Delta-isomerase
–
–
2,4-Dichlorophenoxyacetic_acid + H+ + 2 e- <=> 4-Chlorophenoxyacetate + Cl- 1.97.1
–
S-hydroxymethylglutathione + NAD+ <=> S-formylglutathione + NADH + H+ 1.1.1
1.1.1.1 alcohol dehydrogenase
1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase
1.2.1.46 formaldehyde dehydrogenase
–
–
–
–
2-hydro-1,2-dihydroxybenzoate + NAD+ <=> catechol + CO2 + NADH 1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
–
D-ribose_5-phosphate <=> D-ribulose_5-phosphate 5.3.1.6 ribose-5-phosphate isomerase
–
Sulfide + NADP+ + H2O <=> sulfite + NADPH + H+ 1.8.1.2 assimilatory sulfite reductase (NADPH)
–
thiobenzamide + O2 + NADPH + H+ <=> Thiobenzamide_S-oxide + NADP+ + H2O 1.14.13
–
9-fluorenone + NADH + H+ + O2 <=> 1,1a-dihydroxy-1-hydrofluoren-9-one + NAD+ 1.14.12
1.14.12.22 carbazole 1,9a-dioxygenase
–
–
NAD+ + (1S,2R)-3-Methylcyclohexa-3,5-diene-1,2-diol <=> H+ + NADH + 3-methylcatechol 1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
–
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane <=> H+ + 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + Cl- 4.5.1.1 DDT-dehydrochlorinase
–
sedoheptulose_1,7-diphosphate <=> dihydroxyacetone_phosphate + D-erythrose_4-phosphate 4.1.2.13 fructose-bisphosphate aldolase
–
xylene + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 3-methylbenzyl_alcohol + oxidized_ferredoxin + H2O 1.14.15.26 toluene methyl-monooxygenase
–
Sulfide + oxidized_ferredoxin + H2O <=> sulfite + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.8.7.1 assimilatory sulfite reductase (ferredoxin)
–
beta-D-glucose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.9 glucose-6-phosphate isomerase
–
NH3 + NADP+ + H2O <=> nitrite + NADPH + H+ 1.7.1.4 nitrite reductase [NAD(P)H]
1.7.7.1 ferredoxin---nitrite reductase
1.8.1.2 assimilatory sulfite reductase (NADPH)
–
–
–
5-Aminopentanamide + H2O <=> 5-Aminopentanoate + NH3 3.5.1.30 5-aminopentanamidase
–
L-threo-3-methylaspartate <=> NH3 + mesaconate 4.3.1.2 methylaspartate ammonia-lyase
–
succinate_semialdehyde + NADP+ + CoA <=> succinyl-CoA + NADPH + H+ 1.2.1.75 malonyl-CoA reductase (malonate semialdehyde-forming)
1.2.1.76 succinate-semialdehyde dehydrogenase (acylating)
–
–
tetrachlorohydroquinone + NAD+ + H+ <=> tetrafluoro-1,4-benzoquinone + NADH 1.1.1.404 tetrachlorobenzoquinone reductase
–
scyllo-inosose <=> H2O + 3D-3,5/4-trihydroxycyclohexa-1,2-dione 4.2.1.44 myo-inosose-2 dehydratase
–
4-methylaminobutanoate + O2 + H2O <=> 4-aminobutanoate + formaldehyde + H2O2 1.5.3.19 4-methylaminobutanoate oxidase (formaldehyde-forming)
–
H+ + sulfate + ATP <=> adenosine_5''-phosphosulfate + diphosphate 2.7.7.4 sulfate adenylyltransferase
–
Benzo[a]pyrene-trans-11,12-dihydrodiol <=> 11,12-Dihydroxybenzo[a]pyrene 1.3
–
ATP + NH3 + CO2 + H2O <=> ADP + phosphate + Carbamoyl_phosphate 6.3.4.16 carbamoyl-phosphate synthase (ammonia)
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing)
–
–
4-Aminobenzoic_acid + O2 + NADH + H+ <=> 4-Aminophenol + CO2 + H2O + NAD+ 1.14.13.27 4-aminobenzoate 1-monooxygenase
–
2,4-Diamino-6-hydroxylaminotoluene <=> 2,4,6-Triaminotoluene 1.8.99.5 dissimilatory sulfite reductase
–
cyclohexa-1,5-diene-1-carbonyl-CoA <=> cyclohexa-2,5-diene-1-carbonyl-CoA not assigned
 –
2-methyl-p-cresol + 4 oxidized_azurin + H2O <=> 3-Methyl-4-hydroxybenzaldehyde + 4 azurin + 4 H+ 1.17.9.1 4-methylphenol dehydrogenase (hydroxylating)
–
Acetylene + H2O <=> acetaldehyde 4.2.1.112 acetylene hydratase
–
H+ + N-Cyclopropylammeline + H2O <=> N-cyclopropylammelide + NH3 3.5.4
–
O2 + 2,3-Dihydroxybenzoate <=> H+ + 3-carboxy-2-hydroxymuconate_semialdehyde 1.13.11.14 2,3-dihydroxybenzoate 3,4-dioxygenase
–
pyridoxal + NAD+ <=> 4-Pyridoxolactone + NADH + H+ 1.1.1.107 pyridoxal 4-dehydrogenase
–
4-methyl-5-nitrocatechol + O2 + NADPH <=> H+ + 2-hydroxy-5-methylquinone + NADP+ + nitrite + H2O 1.14.13.210 4-methyl-5-nitrocatechol 5-monooxygenase
–
6-carboxyhex-2-enoyl-CoA + H2O <=> 3-hydroxypimeloyl-CoA 4.2.1
–
1,1a-dihydroxy-1-hydrofluoren-9-one + H2O <=> 2,3-Dihydroxy-2''-carboxybiphenyl + 2 H+ 1.3
–
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate 6.2.1.41 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate---CoA ligase
–
H2O + dihydrocoumarin <=> H+ + melilotate 3.1.1.25 1,4-lactonase
3.1.1.35 dihydrocoumarin hydrolase
–
–
D-fructose_1,6-bisphosphate <=> dihydroxyacetone_phosphate + D-glyceraldehyde_3-phosphate 4.1.2.13 fructose-bisphosphate aldolase
4.1.2.40 tagatose-bisphosphate aldolase
–
–
2,4,5-trichloro-2,5-cyclohexadiene-1-ol + H2O <=> 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + Hydrochloric_acid 3.8.1.5 haloalkane dehalogenase
–
D-fructose_1,6-bisphosphate + H2O <=> beta-D-fructose_6-phosphate + phosphate 3.1.3.11 fructose-bisphosphatase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.37 sedoheptulose-bisphosphatase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase
–
–
–
–
trans-cinnamate <=> 3-hydroxycinnamic_acid not assigned
 –
(S)-2-Hydroxy-2-(4-hydroxyphenyl)acetate <=> 4-Hydroxy-D-mandelate 5.1.2.2 mandelate racemase
–
L-aspartate + ATP <=> L-4-aspartyl_phosphate + ADP 2.7.2.4 aspartate kinase
–
L-ribulose_5-phosphate <=> D-xylulose_5-phosphate 5.1.3.4 L-ribulose-5-phosphate 4-epimerase
–
anthranilate + O2 + NADPH + H+ <=> catechol + CO2 + NH3 + NADP+ 1.14.12.1 anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
–
benzo[a]pyrene + NADH + H+ + O2 <=> Benzo[a]pyrene-cis-11,12-dihydrodiol + NAD+ 1.14.12
–
phenanthrene + O2 + NADH + H+ <=> Phenanthrene-1,2-oxide + H2O + NAD+ 1.14.13
–
5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O <=> H+ + 5-formyl-5,6,7,8-tetrahydromethanopterin 3.5.4.27 methenyltetrahydromethanopterin cyclohydrolase
–
N-hydroxyaniline + NADP+ <=> nitrosobenzene + NADPH + H+ 1.7.1.16 nitrobenzene nitroreductase
–
Tribromobisphenol_A <=> Dibromobisphenol_A + Hydrobromic_acid 1.97.1
–
D-glyceraldehyde + H2O + NADP+ <=> D-glycerate + NADPH + H+ 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.8 betaine-aldehyde dehydrogenase
1.2.1.89 D-glyceraldehyde dehydrogenase (NADP+)
–
–
–
–
–
–
S-adenosyl-L-methionine + uroporphyrinogen_III <=> S-adenosyl-L-homocysteine + precorrin-2 + H+ 2.1.1.107 uroporphyrinogen-III C-methyltransferase
–
5-methoxygallic_acid + O2 <=> H+ + 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate 1.13.11
1.13.11.8 protocatechuate 4,5-dioxygenase
–
–
4-hydroxy-4-methyl-2-oxoglutarate <=> pyruvate 4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase
–
2-hydroxy-2H-chromene-2-carboxylate <=> (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate 2.5.1.18 glutathione transferase
5.99.1.4 2-hydroxychromene-2-carboxylate isomerase
–
–
bisphenol_A <=> 5-Hydroxybisphenol_A not assigned
 –
2,4,5-Trichlorophenol + O2 + FADH2 <=> 2,5-dichlorohydroquinone + Cl- + H2O + FAD + H+ 1.14.14
–
protoanemonin + H2O <=> cis-acetylacrylate 3.1.1.45 carboxymethylenebutenolidase
–
beta-2,3,4,5,6-Pentachlorocyclohexanol + H2O <=> beta-2,3,5,6-Tetrachloro-1,4-cyclohexanediol + Hydrochloric_acid 3.8.1.5 haloalkane dehalogenase
–
beta-hexachlorocyclohexane <=> delta-3,4,5,6-Tetrachlorocyclohexene + 2 Cl- not assigned
 –
4-Carboxymethyl-3-methylbut-2-en-1,4-olide <=> 4-methyl-3-oxoadipate_enol-lactone 5.3.3
5.3.3.4 muconolactone Delta-isomerase
5.4.99.14 4-carboxymethyl-4-methylbutenolide mutase
5.5.1
–
–
–
–
cyanuric_acid + H2O <=> carboxybiuret + H+ 3.5.2.15 cyanuric acid amidohydrolase
–
2,2,2-trichloroethanol <=> chloral 1.1
–
(2E,4Z)-2-hydroxyhexa-2,4-dienoate + H2O <=> 4-hydroxy-2-oxohexanoate 4.2.1.132 2-hydroxyhexa-2,4-dienoate hydratase
–
cis,cis-2,4-Dihydroxy-5-methyl-6-oxo-2,4-hexadienoate + H2O <=> L-2-methyl-3-oxopropionate + pyruvate 3.7.1
–
H2O + cyclohexyl_sulfamate <=> sulfate + Cyclohexylamine 3.10.1.2 cyclamate sulfohydrolase
–
bithionol + phosphate + ADP <=> 3-hydroxypropionate + CoA + ATP 6.2.1
–
H+ + 1,4-benzoquinone + NADPH <=> hydroquinone + NADP+ 1.1.1.328 nicotine blue oxidoreductase
1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.6.5.10 NADPH dehydrogenase (quinone)
1.6.5.2 NAD(P)H dehydrogenase (quinone)
1.6.5.5 NADPH:quinone reductase
1.6.5.6 p-benzoquinone reductase (NADPH)
1.7.1.6 azobenzene reductase
1.8.1.9 thioredoxin-disulfide reductase
–
–
–
–
–
–
–
–
acetyl-CoA + L-lactate <=> acetate + lactoyl-CoA 2.8.3.1 propionate CoA-transferase
–
Caffeine + NADPH + O2 + H+ <=> Theobromine + NADP+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase
–
–
NTP + pyruvate <=> NDP + phosphoenolpyruvate 2.7.1.40 pyruvate kinase
–
2-Fluorobenzoate + NADH + H+ + O2 <=> 2-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate + NAD+ 1.14.12.10 benzoate 1,2-dioxygenase
–
D-glucose + NAD+ <=> D-glucono-1,5-lactone + NADH + H+ 1.1.1.118 glucose 1-dehydrogenase (NAD+)
1.1.1.119 glucose 1-dehydrogenase (NADP+)
1.1.1.121 aldose 1-dehydrogenase (NAD+)
1.1.1.179 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming)
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]
–
–
–
–
–
(2R,3S)-dimethylmalate <=> dimethylmaleate + H2O 4.2.1.85 dimethylmaleate hydratase
–
D-lactate + H+ <=> methylglyoxal + H2O 3.5.1.124 protein deglycase
4.2.1.130 D-lactate dehydratase
–
–
5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD+ <=> 3-hydroxy-2-methylpyridine-4,5-dicarboxylate + NADH + H+ 1.2.1.100 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase
–
NH3 + H2O + oxidized_ferredoxin <=> nitrite + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.7.7.1 ferredoxin---nitrite reductase
1.8.7.1 assimilatory sulfite reductase (ferredoxin)
–
–
D-chiro-Inositol + NAD+ <=> 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+ 1.1.1.18 inositol 2-dehydrogenase
1.1.1.369 D-chiro-inositol 1-dehydrogenase
–
–
(2S)-2-phospholactate + GTP + H+ <=> L-lactyl-2-diphospho-5''-guanosine + diphosphate 2.7.7.68 2-phospho-L-lactate guanylyltransferase
–
H+ + 2-amino-6-(N-ethylamino)-4-hydroxy-1,3,5-triazine + H2O <=> 6-(ethylamino)-1,3,5-triazine-2,4-diol + NH3 3.5.4
3.8.1.8 atrazine chlorohydrolase
–
–
4,5-9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic_acid + H2O <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+ 3.7.1.17 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
–
sulfite + a_quinone + H2O <=> sulfate + a_quinol 1.8.5.6 sulfite dehydrogenase (quinone)
–
sulfate + H+ + ADP <=> adenosine_5''-phosphosulfate + phosphate 2.7.7.5 sulfate adenylyltransferase (ADP)
–
2-Hydroxy-3-carboxybenzalpyruvate + H2O <=> 3-Formylsalicylic_acid + pyruvate 4.2.1
–
Toluene + O2 + NADH + H+ <=> p-Cresol + H2O + NAD+ 1.14.13.236 toluene 4-monooxygenase
–
2,6-Diamino-4-nitrotoluene <=> 2,4,6-Triaminotoluene not assigned
 –
Furfuryl_alcohol + NAD+ <=> furfural + NADH + H+ 1.1.1
1.1.1.1 alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.265 3-methylbutanal reductase
1.1.1.307 D-xylose reductase
1.1.1.90 aryl-alcohol dehydrogenase
–
–
–
–
–
–
Caffeine + O2 + NADPH + H+ <=> theophylline + formaldehyde + NADP+ + H2O 1.13.12
1.14.13.128 7-methylxanthine demethylase
–
–
thiosulfate + 5 H2O + 8 ferricytochrome_c <=> 2 sulfate + 8 ferricytochrome_c + 10 H+ not assigned
 –
1,1,1-trichloroethane + NADH + H+ + O2 <=> 2,2,2-trichloroethanol + NAD+ + H2O 1.14.13.25 methane monooxygenase (soluble)
–
biphenyl + O2 + NADH + H+ <=> cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+ 1.14.12.18 biphenyl 2,3-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
–
–
2-Hydroxycyclohexan-1-one + NADPH + O2 <=> 1-Oxa-2-oxo-3-hydroxycycloheptane + NADP+ + H2O 1.14.13.22 cyclohexanone monooxygenase
–
(S)-malate + NADP+ <=> H+ + NADPH + oxaloacetate 1.1.1.299 malate dehydrogenase [NAD(P)+]
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.81 hydroxypyruvate reductase
1.1.1.82 malate dehydrogenase (NADP+)
–
–
–
–
–
–
cis-1,2-dihydrobenzene-3-chloro-(R,R)-1,2-diol + NAD+ <=> 3-chlorocatechol + NADH + H+ 1.3.1.119 chlorobenzene dihydrodiol dehydrogenase
1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
–
–
H+ + gallic_acid <=> CO2 + pyrogallol 4.1.1.59 gallate decarboxylase
4.1.1.61 4-hydroxybenzoate decarboxylase
–
–
6-amino-hexanoate_cyclic_dimer + H2O <=> N-(6-aminohexanoyl)-6-aminohexanoate 3.5.1.117 6-aminohexanoate-oligomer endohydrolase
3.5.2.12 6-aminohexanoate-cyclic-dimer hydrolase
–
–
trichloroacetate <=> CO2 not assigned
 –
N2 + H2O + 2 ferricytochrome_c <=> N2O + 2 ferricytochrome_c + 2 H+ 1.7.2.4 nitrous-oxide reductase
–
4-nitrophenol + NADH + O2 + H+ <=> 4-nitrocatechol + NAD+ + H2O 1.14.13.29 4-nitrophenol 2-monooxygenase
–
Caffeine + NADH + O2 + H+ <=> paraxanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase
–
–
2-hydroxy-2,4-hexadienedioate <=> 4-oxalocrotonate 5.3.2.6 2-hydroxymuconate tautomerase
5.3.2.M1
–
–
CoA + acetate + ATP <=> acetyl-CoA + diphosphate + AMP 6.2.1.1 acetate---CoA ligase
6.2.1.17 propionate---CoA ligase
6.2.1.36 3-hydroxypropionyl-CoA synthase
–
–
–
(Z)-pent-1-ene-1,2,5-tricarboxylate + H2O <=> (-)-threo-iso(homo)2citrate 4.2.1.114 methanogen homoaconitase
–
D-glucose <=> D-glucose 5.1.3.21 maltose epimerase
5.1.3.3 aldose 1-epimerase
–
–
L-aspartate_4-semialdehyde + NAD+ + H2O <=> L-aspartate + NADH + H+ 1.2.1
1.2.1.M5
–
–
1,4-dichlorobenzene <=> chlorobenzene not assigned
 –
H+ + Phosphonopyruvate <=> phosphonoacetaldehyde + CO2 4.1.1.82 phosphonopyruvate decarboxylase
–
2-Methyleneglutarate <=> (R)-3-methylitaconate 5.4.99.4 2-methyleneglutarate mutase
–
3-Fluorobenzoate + NADH + H+ + O2 <=> 5-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate + NAD+ 1.14.12.10 benzoate 1,2-dioxygenase
–
6-phospho-D-glucosaminate <=> 2-keto-3-deoxy_phosphogluconate + NH3 4.3.1.29 D-glucosaminate-6-phosphate ammonia-lyase
–
5-Aminopentanoate + 2-oxoglutarate <=> L-glutamate + 5-Oxopentanoate 2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2 alanine transaminase
2.6.1.48 5-aminovalerate transaminase
–
–
–
4-Aminocatechol + H2O <=> Hydroxyquinol + NH3 not assigned
 –
3,4-Dihydroxy-3,4-dihydro-9-fluorenone <=> 4-Hydroxy-9-fluorenone + H2O not assigned
 –
H2O + Phosphonoacetate <=> H+ + phosphate + acetate 3.11.1.2 phosphonoacetate hydrolase
–
4-chloroaniline + O2 + 2 H+ <=> 4-Chlorocatechol + NH3 1.14
–
Benzo[a]pyrene-cis-7,8-dihydrodiol + O2 <=> cis-4-(7-Hydroxtpyren-8-yl)-2-oxobut-3-enoate not assigned
 –
2,5-dichloromaleylacetate + NADH <=> 2-chloro-3-oxohexanedioic_acid + NAD+ + Cl- 1.3.1.32 maleylacetate reductase
–
cis-1,2-Dihydroxy-1,2-dihydro-7-methylnaphthalene <=> 4-methylsalicylate not assigned
 –
O2 + cholesterol <=> cholest-4-en-3-one + H2O2 1.1.3.6 cholesterol oxidase
–
guaiacol + reduced_flavodoxin + O2 <=> catechol + flavin + formaldehyde + H2O 1.14.14
–
H+ + salicylate + O2 + NADH <=> catechol + CO2 + H2O + NAD+ 1.14.13.1 salicylate 1-monooxygenase
–
4-amino-2-nitrotoluene + 3 NADH + 3 H+ <=> 2,4-Diaminotoluene + 3 NAD+ + 2 H2O 1.7.1
–
2,3-Dihydroxy-p-cumate + O2 <=> 2-Hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate + H+ 1.13.11
1.13.11.M5
–
–
4-hydroxylamino-2,6-dinitrotoluene + NADPH + H+ <=> 4-amino-2,6-dinitrotoluene + NADP+ + H2O 1.7.1
–
methylamine + L-glutamate <=> N-Methyl-L-glutamate + NH3 2.1.1.21 methylamine---glutamate N-methyltransferase
–
D-glycerate + NAD+ <=> H+ + Hydroxypyruvate + NADH 1.1.1.237 hydroxyphenylpyruvate reductase
1.1.1.26 glyoxylate reductase
1.1.1.27 L-lactate dehydrogenase
1.1.1.28 D-lactate dehydrogenase
1.1.1.29 glycerate dehydrogenase
1.1.1.60 2-hydroxy-3-oxopropionate reductase
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.81 hydroxypyruvate reductase
1.1.1.92 oxaloglycolate reductase (decarboxylating)
–
–
–
–
–
–
–
–
–
3-isochromanone <=> catechol not assigned
 –
3-hydroxy-2-naphthoate + O2 <=> 3-[6-(Carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate 1.13.11
–
nicotinate + H2O + Ferrocytochrome <=> 6-Hydroxynicotinate + Ferrocytochrome + H+ 1.17.2.1 nicotinate dehydrogenase (cytochrome)
–
2-Hydroxy-2-hydropyrone-4,6-dicarboxylate + NAD+ <=> 2-Pyrone-4,6-dicarboxylate + NADH + H+ 1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
–
Dibromobisphenol_A <=> Monobromobisphenol_A + Hydrobromic_acid 1.97.1
–
9-fluorenone + O2 + 2 NADH <=> 3,4-Dihydroxy-3,4-dihydro-9-fluorenone + 2 NAD+ 1.14.12
–
2-Carboxy-2-hydroxy-8-carboxychromene <=> 2-Hydroxy-3-carboxybenzalpyruvate 5.3.99
–
4-hydroxybutyrate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + ADP + phosphate 6.2.1.56 4-hydroxybutyrate---CoA ligase (ADP-forming)
–
3-Methyl-4-hydroxybenzaldehyde + NADP+ + H2O <=> 4-hydroxy-3-methylbenzoate + NADPH + H+ 1.2.1.96 4-hydroxybenzaldehyde dehydrogenase (NADP+)
–
3,4-Dihydroxyfluorene + O2 <=> 2-Hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene)-but-2-enoic_acid 1.13.11
–
1,1-Dichloro-2-(dihydroxy-4''-chlorophenyl)-2-(4''-chlorophenyl)ethylene + O2 <=> 6-Oxo-2-hydroxy-7-(4''-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7E-trienoate 1.13.11
–
Theobromine + NADPH + O2 + H+ <=> 7-methylxanthine + NADP+ + formaldehyde + H2O 1.14.13.179 methylxanthine N3-demethylase
–
n-butane + NADH + O2 + H+ <=> 1-butanol + NAD+ + H2O 1.14.13.230 butane monooxygenase (soluble)
–
oxaloacetate + ATP <=> CO2 + phosphoenolpyruvate + ADP 4.1.1.31 phosphoenolpyruvate carboxylase
4.1.1.38 phosphoenolpyruvate carboxykinase (diphosphate)
4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)
–
–
–
succinate + NAD+ <=> fumarate + NADH + H+ 1.3.1.6 fumarate reductase (NADH)
–
NADP+ + H2O + L-glutamate <=> NADPH + 2-oxoglutarate + NH3 + H+ 1.4.1.13 glutamate synthase (NADPH)
1.4.1.2 glutamate dehydrogenase
1.4.1.3 glutamate dehydrogenase [NAD(P)+]
1.4.1.4 glutamate dehydrogenase (NADP+)
–
–
–
–
3,5-Dichloro-2-methylmuconolactone <=> 3-chloro-2-methyl-dienelactone + Cl- + H+ 4.5.1
5.5.1.7 chloromuconate cycloisomerase
–
–
L-lysine <=> (3R)-3-methyl-D-ornithine 5.4.99.58 methylornithine synthase
–
(R)-2-methylmalonyl-CoA <=> succinyl-CoA 5.4.99.2 methylmalonyl-CoA mutase
5.4.99.63 ethylmalonyl-CoA mutase
5.4.99.64 2-hydroxyisobutanoyl-CoA mutase
–
–
–
2 deisopropylatrazine + O2 <=> 2 2-chloro-4,6-diamino-s-triazine + 2 acetaldehyde 1.14.15
–
4-sulfomuconolactone + H2O <=> maleylacetate + sulfite + H+ 3.1.1.92 4-sulfomuconolactone hydrolase
–
O2 + Vanillyl_alcohol <=> Vanillin + H2O2 1.1.3.38 vanillyl-alcohol oxidase
1.1.3.47 5-(hydroxymethyl)furfural oxidase
1.1.3.7 aryl-alcohol oxidase
–
–
–
2-Pyrone-4,6-dicarboxylate + H2O <=> 4-oxalomesaconate + H+ 3.1.1.57 2-pyrone-4,6-dicarboxylate lactonase
–
H+ + furan-2,5-dicarboxylate <=> Furoic_acid + CO2 not assigned
 –
O-phospho-L-homoserine + H2O <=> phosphate + L-threonine 4.2.3.1 threonine synthase
–
CO + H2O + oxidized_ferredoxin <=> CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.4 anaerobic carbon monoxide dehydrogenase
–
melilotate + ATP + CoA + FAD + NAD+ <=> salicylate + AMP + diphosphate + FADH2 + acetyl-CoA + NADH + H+ not assigned
 –
oxaloacetate + acetyl-CoA + phosphate + ADP <=> citrate + CoA + ATP 2.3.3.8 ATP citrate synthase
–
Cyclohexane + NADH + H+ + O2 <=> Cyclohexanol + NAD+ + H2O 1.14.13
1.14.13.25 methane monooxygenase (soluble)
1.14.15.3 alkane 1-monooxygenase
–
–
–
3,5-dibromo-4-hydroxybenzoic_acid <=> 2,6-dibromophenol not assigned
 –
cholest-4-en-3-one + reduced_ferredoxin_[iron-sulfur]_cluster + H+ + O2 <=> (25S)-3-oxocholest-4-en-26-oate + oxidized_ferredoxin + H2O 1.14.15.29 cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]
–
4-aminobutanoate + pyruvate <=> succinate_semialdehyde + L-alanine 2.6.1.116 6-aminohexanoate aminotransferase
2.6.1.18 beta-alanine---pyruvate transaminase
2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.40 (R)-3-amino-2-methylpropionate---pyruvate transaminase
2.6.1.96 4-aminobutyrate---pyruvate transaminase
–
–
–
–
–
(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O <=> Salicylaldehyde + pyruvate 4.1.2.45 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
–
alpha-D-glucose_1-phosphate <=> alpha-D-glucose_6-phosphate 5.4.2.10 phosphoglucosamine mutase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.3 phosphoacetylglucosamine mutase
5.4.2.5 phosphoglucomutase (glucose-cofactor)
5.4.2.6 beta-phosphoglucomutase
5.4.2.8 phosphomannomutase
–
–
–
–
–
–
3-oxoadipate + NADP+ <=> maleylacetate + NADPH + H+ 1.3.1.32 maleylacetate reductase
–
3-Methylxanthine + NADH + O2 + H+ <=> xanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase
–
–
propionyl-CoA + NADP+ <=> acryloyl-CoA + NADPH + H+ 1.3.1
1.3.1.84 acrylyl-CoA reductase (NADPH)
1.3.1.95 acrylyl-CoA reductase (NADH)
–
–
–
2,4-Diamino-6-nitrotoluene + acetyl-CoA <=> 4-Acetamido-2-amino-6-nitrotoluene + CoA 2.3.1.5 arylamine N-acetyltransferase
–
2,2,3-trichlorooxirane <=> CO not assigned
 –
2-Hydroxy-6-oxoocta-2,4,7-trienoate + H2O <=> 2-hydroxy-2,4-pentadienoate + Acrylate 3.7.1.9 2-hydroxymuconate-6-semialdehyde hydrolase
–
cyclohex-1-ene-1-carbonyl-CoA + H2O <=> 2-hydroxycyclohexane-1-carbonyl-CoA 4.2.1
4.2.1.100 cyclohexa-1,5-dienecarbonyl-CoA hydratase
–
–
ethanol + 2 ferricytochrome_c <=> acetaldehyde + 2 ferricytochrome_c 1.1.2.8 alcohol dehydrogenase (cytochrome c)
1.1.2.9 1-butanol dehydrogenase (cytochrome c)
–
–
(S)-1-phenylethanol + NAD+ <=> H+ + acetophenone + NADH 1.1.1.1 alcohol dehydrogenase
1.1.1.14 L-iditol 2-dehydrogenase
1.1.1.311 (S)-1-phenylethanol dehydrogenase
1.1.1.B3
–
–
–
–
phenol + O2 + NADH + H+ <=> catechol + H2O + NAD+ 1.14.13.244 phenol 2-monooxygenase (NADH)
1.14.13.7 phenol 2-monooxygenase (NADPH)
1.14.14.20 phenol 2-monooxygenase (FADH2)
–
–
–
1-(4'-hydroxyphenyl)ethanol + NAD+ <=> 4-hydroxyacetophenone + NADH + H+ 1.1.1
1.1.1.311 (S)-1-phenylethanol dehydrogenase
1.1.1.B3
1.14.13.84 4-hydroxyacetophenone monooxygenase
–
–
–
–
1-methylnaphthalene + O2 + NADH + H+ <=> cis-1,2-Dihydroxy-1,2-dihydro-8-methylnaphthalene + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase
–
5,6,7,8-Tetrahydro-2-naphthoic_acid <=> Decahydro-2-naphthoic_acid not assigned
 –
acetaldehyde + NADP+ + H2O <=> acetate + NADPH + H+ 1.2.1
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.8 betaine-aldehyde dehydrogenase
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
–
–
–
–
–
–
–
–
–
coenzyme_B + coenzyme_M + methanophenazine <=> CoM-S-S-CoB + dihydromethanophenazine 1.8.98.1 dihydromethanophenazine:CoB-CoM heterodisulfide reductase
–
1,2-Dihydrophthalic_acid + NAD+ <=> Phthalate + NADH + H+ 1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
–
(S)-3-hydroxybutyryl-CoA + NADP+ <=> acetoacetyl-CoA + NADPH + H+ 1.1.1.157 3-hydroxybutyryl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
–
–
2 Atrazine + O2 <=> 2 desethylatrazine + 2 acetaldehyde 1.14.15
–
2,2'',3-Trihydroxy-3''-methoxy-5,5''-dicarboxybiphenyl + O2 <=> 4-[2-(5-Carboxy-2-hydroxy-3-methoxyphenyl)-2-oxoethylidene]-2-hydroxy-2-pentenedioate not assigned
 –
L-threonine <=> glycine + acetaldehyde 4.1.2.26 phenylserine aldolase
4.1.2.42 D-threonine aldolase
4.1.2.48 low-specificity L-threonine aldolase
4.1.2.5 L-threonine aldolase
–
–
–
–
3-sulfocatechol + O2 + H2O <=> 2-hydroxy-2,4-hexadienedioate + sulfite + H+ 1.13.11.2 catechol 2,3-dioxygenase
–
Chloroacetaldehyde + H2O + NAD+ <=> H+ + Chloroacetate + NADH 1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.69 fluoroacetaldehyde dehydrogenase
–
–
–
–
2,4,5-Trihydroxytoluene + O2 <=> H+ + cis,cis-2,4-Dihydroxy-5-methyl-6-oxo-2,4-hexadienoate 1.13.11
–
delta-3,4,5,6-Tetrachlorocyclohexene <=> 5,6-Dichloro-1,3-cyclohexadiene + 2 Cl- not assigned
 –
pyruvate + pyridoxamine <=> L-alanine + pyridoxal 2.6.1.30 pyridoxamine---pyruvate transaminase
–
(2R)-3-sulfolactate + NADP+ <=> 3-sulfopyruvate + NADPH + H+ 1.1.1.338 (2R)-3-sulfolactate dehydrogenase (NADP+)
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
–
–
4-hydroxybenzoyl-CoA + H2O <=> H+ + 4-hydroxybenzoate + CoA 3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.23 4-hydroxybenzoyl-CoA thioesterase
–
–
–
2-dehydro-3-deoxy-D-gluconate + ATP <=> H+ + 2-keto-3-deoxy_phosphogluconate + ADP 2.7.1.178 2-dehydro-3-deoxyglucono/galactono-kinase
2.7.1.45 2-dehydro-3-deoxygluconokinase
–
–
4,6-Dichloro-3-methylcatechol + O2 <=> 3,5-Dichloro-2-methylmuconate + H+ 1.13.11
–
2,5-dihydroxybenzaldehyde + NAD+ <=> 2,5-Dihydroxybenzoate + NADH 1.2.1.29 aryl-aldehyde dehydrogenase
–
3,5-dichlorocatechol + O2 <=> 2,4-dichloro-cis,cis-muconate + H+ 1.13.11
1.13.11.1 catechol 1,2-dioxygenase
1.13.11.M6
–
–
–
cis-4-(8-Hydroxypyren-7-yl)-2-oxobut-3-enoate <=> 7,8-Dihydropyrene-7-carboxylate not assigned
 –
H+ + 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O <=> N-isopropylammelide + ethylamine 3.5.4.43 hydroxydechloroatrazine ethylaminohydrolase
–
(S)-malate + H+ <=> L-lactate + CO2 4.1.1.101 malolactic enzyme
–
2,4,6-trinitrotoluene + 2 NADH + 2 H+ <=> 4-hydroxylamino-2,6-dinitrotoluene + 2 NAD+ + H2O 1
–
5-Aminopentanal + NAD+ + H2O <=> 5-Aminopentanoate + NADH + H+ 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
–
–
2 reduced_ferredoxin + 2 H+ + Acetylene + 2 ATP + 2 H2O <=> 2 oxidized_ferredoxin + ethylene + 2 ADP + 2 phosphate 1.18.6.1 nitrogenase
–
4,5-Chrysenedicarboxylate <=> 4-Chrysenecarboxylate + CO2 4.1.1
–
H2O + alpha-D-glucose_1-phosphate <=> phosphate + D-glucose 2.4.1.7 sucrose phosphorylase
3.1.3
3.1.3.1 alkaline phosphatase
3.1.3.10 glucose-1-phosphatase
3.1.3.11 fructose-bisphosphatase
3.1.3.2 acid phosphatase
3.1.3.23 sugar-phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.26 4-phytase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.37 sedoheptulose-bisphosphatase
3.1.3.58 sugar-terminal-phosphatase
3.1.3.8 3-phytase
3.1.3.93 L-galactose 1-phosphate phosphatase
3.6.1.1 inorganic diphosphatase
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
benzoyl-CoA + oxidized_ferredoxin + H2O <=> 4-hydroxybenzoyl-CoA + reduced_ferredoxin 1.1.7.1 4-hydroxybenzoyl-CoA reductase
–
butyryl-CoA + FAD <=> crotonyl-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
1.3.8.1 short-chain acyl-CoA dehydrogenase
1.3.8.4 isovaleryl-CoA dehydrogenase
1.3.8.7 medium-chain acyl-CoA dehydrogenase
1.3.99
–
–
–
–
–
Pyrene-4,5-dione + NADH + H+ <=> 4,5-dihydroxypyrene + NAD+ 1.6.5
–
an_alcohol + NADP+ <=> an_aldehyde + NADPH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.191 indole-3-acetaldehyde reductase (NADPH)
1.1.1.195 cinnamyl-alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.215 gluconate 2-dehydrogenase
1.1.1.263 1,5-anhydro-D-fructose reductase
1.1.1.265 3-methylbutanal reductase
1.1.1.283 methylglyoxal reductase (NADPH)
1.1.1.4 (R,R)-butanediol dehydrogenase
1.1.1.61 4-hydroxybutyrate dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.72 glycerol dehydrogenase (NADP+)
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.80 isopropanol dehydrogenase (NADP+)
1.1.1.91 aryl-alcohol dehydrogenase (NADP+)
1.1.1.97 3-hydroxybenzyl-alcohol dehydrogenase
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
paraxanthine + NADPH + O2 + H+ <=> 7-methylxanthine + NADP+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase
–
–
ATP + alpha-D-glucose <=> ADP + alpha-D-glucose_6-phosphate 2.7.1.1 hexokinase
2.7.1.2 glucokinase
–
–
(2E,4Z)-2-hydroxy-5-methylhexa-2,4-diendioate <=> 2-Oxo-5-methyl-cis-muconate 5.3.2.6 2-hydroxymuconate tautomerase
–
H+ + cumic_acid + NADH + O2 <=> cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate + NAD+ 1.14.12.25 p-cumate 2,3-dioxygenase
–
2-Hydroxy-4-hydroxymethylbenzalpyruvate + H2O <=> 4-Hydroxymethylsalicylaldehyde + pyruvate 4.2.1
–
Cl- + hydroquinone + GSSG + H+ <=> chlorohydroquinone + glutathione 2.5.1
–
trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide + H2O <=> 2-chloromaleylacetate + H+ 3.1.1.45 carboxymethylenebutenolidase
–
acetaldehyde + CoA + NAD+ <=> acetyl-CoA + NADH + H+ 1.2.1.10 acetaldehyde dehydrogenase (acetylating)
1.2.1.42 hexadecanal dehydrogenase (acylating)
1.2.1.57 butanal dehydrogenase
1.2.1.87 propanal dehydrogenase (CoA-propanoylating)
–
–
–
–
benzo[a]pyrene + O2 <=> Benzo[a]pyrene-11,12-epoxide 1.14
–
H+ + phosphoenolpyruvate <=> Phosphonopyruvate 5.4.2.9 phosphoenolpyruvate mutase
–
2-chloro-3-oxohexanedioic_acid <=> Chloroacetate + succinate not assigned
 –
N-formylmaleamic_acid + H2O <=> H+ + Maleamate + formate 3.5.1.106 N-formylmaleamate deformylase
–
2,5-Dihydroxybenzoate + O2 <=> maleylpyruvate + H+ 1.13.11.4 gentisate 1,2-dioxygenase
1.13.11.86 5-aminosalicylate 1,2-dioxygenase
–
–
2-bromomaleylacetate + NADH <=> maleylacetate + NAD+ + Br- 1.3.1.32 maleylacetate reductase
–
2-amino-4-chloro-6-hydroxy-1,3,5-triazine + H2O <=> ammelide + Cl- 3.5.4.43 hydroxydechloroatrazine ethylaminohydrolase
3.8.1.8 atrazine chlorohydrolase
–
–
Styrene + O2 + NADH + H+ <=> Styrene-cis-2,3-dihydrodiol + NAD+ 1.14.12
–
CoA + 4-hydroxybenzoate + ATP <=> 4-hydroxybenzoyl-CoA + diphosphate + AMP 6.2.1.27 4-hydroxybenzoate---CoA ligase
–
3-phospho-D-glycerate + NAD+ <=> H+ + 3-phosphohydroxypyruvate + NADH 1.1.1.95 phosphoglycerate dehydrogenase
–
1,6-dihydroxypyrene <=> 1,6-pyrenequinone not assigned
 –
3-ethylcatechol + O2 <=> 2-hydroxy-6-oxoocta-2,4-dienoate 1.13.11
1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase
–
–
deisopropylatrazine + H2O <=> H+ + 2-amino-6-(N-ethylamino)-4-hydroxy-1,3,5-triazine + Cl- 3.8.1
–
beta-D-glucose_6-phosphate + NADP+ <=> 6-phospho-D-glucono-1,5-lactone + NADPH 1.1.1.363 glucose-6-phosphate dehydrogenase [NAD(P)+]
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]
1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)
–
–
–
acetophenone + HCO3- + ATP + H2O <=> H+ + 3-oxo-3-phenylpropionic_acid + ADP + phosphate 6.4.1.8 acetophenone carboxylase
–
H+ + Urea + H2O <=> NH3 + CO2 3.5.1.5 urease
–
Chloroacetate + H2O <=> H+ + glycolate + Cl- 3.8.1.10 2-haloacid dehalogenase (configuration-inverting)
3.8.1.2 (S)-2-haloacid dehalogenase
3.8.1.3 haloacetate dehalogenase
3.8.1.5 haloalkane dehalogenase
3.8.1.9 (R)-2-haloacid dehalogenase
–
–
–
–
–
Benzamide + H2O <=> benzoate + NH3 3.5.1.13 aryl-acylamidase
3.5.1.19 nicotinamidase
3.5.1.4 amidase
3.5.5.1 nitrilase
–
–
–
–
2,2,3-trichlorooxirane <=> Dichloroacetate not assigned
 –
Phenyl_phosphate + CO2 + H2O <=> H+ + 4-hydroxybenzoate + phosphate 4.1.1.61 4-hydroxybenzoate decarboxylase
6.4.1
–
–
H+ + ammelide + H2O <=> cyanuric_acid + NH3 3.5.4.3 guanine deaminase
3.5.4.42 N-isopropylammelide isopropylaminohydrolase
–
–
succinate_semialdehyde + NADP+ + H2O <=> NADPH + succinate + H+ 1.1.1.21 aldose reductase
1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.79 succinate-semialdehyde dehydrogenase (NADP+)
–
–
–
–
–
benzaldehyde + H2O + NAD+ <=> aromatic_carboxylate + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.29 aryl-aldehyde dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase
1.2.1.48 long-chain-aldehyde dehydrogenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.64 4-hydroxybenzaldehyde dehydrogenase (NAD+)
1.2.1.65 salicylaldehyde dehydrogenase
1.2.1.67 vanillin dehydrogenase
1.2.1.69 fluoroacetaldehyde dehydrogenase
–
–
–
–
–
–
–
–
–
–
–
–
–
cis-4,5-Dihydroxy-4,5-dihydropyrene + NAD+ <=> 4,5-dihydroxypyrene + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
–
1-Formyl-2-indanone + H2O <=> 2-indanone + CO2 + 2 H+ + 2 e- not assigned
 –
6-phosphogluconate + NADP+ <=> 6-phospho-2-dehydro-D-gluconate + NADPH + H+ 1.1.1.43 phosphogluconate 2-dehydrogenase
–
1-hydroxy-2-naphthoate + NADH + O2 + H+ <=> 1,2-dihydroxynaphthalene + NAD+ + H2O + CO2 1.14.13.1 salicylate 1-monooxygenase
1.14.13.135 1-hydroxy-2-naphthoate hydroxylase
–
–
3-Hydroxy-2-methylpyridine-5-carboxylate + NADPH + H+ + O2 <=> 2-(Acetamidomethylene)succinate + NADP+ 1.14.13.242 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase
–
2,6-dichlorohydroquinone + Cl- + GSSG + H+ <=> 2,3,5-trichlorohydroquinone + glutathione 1.21.4.5 tetrachlorohydroquinone reductive dehalogenase
–
2-Oxo-5-methyl-cis-muconate <=> (2E,4Z)-2-hydroxyhexa-2,4-dienoate + CO2 4.1.1.77 2-oxo-3-hexenedioate decarboxylase
–
4-carboxymethyl-4-methylbut-2-en-1,4-olide <=> 3-methyl-cis,cis-muconate + H+ 5.5.1.1 muconate cycloisomerase
5.5.1.7 chloromuconate cycloisomerase
–
–
beta-D-fructose_6-phosphate + diphosphate <=> H+ + phosphate + D-fructose_1,6-bisphosphate 2.7.1.90 diphosphate---fructose-6-phosphate 1-phosphotransferase
–
4-nitrophenol + O2 + NADPH + H+ <=> 1,4-benzoquinone + nitrite + H2O + NADP+ 1.14.13.167 4-nitrophenol 4-monooxygenase
1.14.13.210 4-methyl-5-nitrocatechol 5-monooxygenase
–
–
2-Hydroxyisophthalic_acid <=> salicylate + CO2 4.1.1
–
L-rhamnose + NADP+ <=> L-Rhamno-1,4-lactone + NADPH + H+ 1.1.1.173 L-rhamnose 1-dehydrogenase
1.1.1.377 L-rhamnose 1-dehydrogenase (NADP+)
1.1.1.378 L-rhamnose 1-dehydrogenase [NAD(P)+]
–
–
–
2,6-dichlorophenol + O2 + NADH + H+ <=> 2,6-dichlorohydroquinone + NAD+ + H2O 1.14.13
–
L-lysine + H+ <=> cadaverine + CO2 4.1.1.17 ornithine decarboxylase
4.1.1.18 lysine decarboxylase
4.1.1.19 arginine decarboxylase
4.1.1.50 adenosylmethionine decarboxylase
4.1.1.86 diaminobutyrate decarboxylase
4.1.1.B12
–
–
–
–
–
–
3-fumarylpyruvate + H2O <=> H+ + fumarate + pyruvate 3.7.1
3.7.1.20 3-fumarylpyruvate hydrolase
3.7.1.5 acylpyruvate hydrolase
4.1.1.112 oxaloacetate decarboxylase
–
–
–
–
2 thiosulfate + decylubiquinone + 2 H+ <=> tetrathionate + decylubiquinol 1.8.5.2 thiosulfate dehydrogenase (quinone)
–
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate <=> (S)-allantoin + CO2 4.1.1.97 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
–
Vanillin + H2O + NAD+ <=> vanillic_acid + NADH + H+ 1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.29 aryl-aldehyde dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.64 4-hydroxybenzaldehyde dehydrogenase (NAD+)
1.2.1.67 vanillin dehydrogenase
1.2.1.7 benzaldehyde dehydrogenase (NADP+)
–
–
–
–
–
–
1,4-androstadiene-3,17-dione + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 9alpha-hydroxy-1,4-androstadiene_3,17-dione + oxidized_ferredoxin + H2O 1.14.15.30 3-ketosteroid 9alpha-monooxygenase
–
syringic_acid + tetrahydrofolate <=> 5-methoxygallic_acid + 5-methyltetrahydrofolate 2.1.1
2.1.1.341 vanillate/3-O-methylgallate O-demethylase
–
–
1-hydroxy-2-naphthaldehyde + NAD+ + H2O <=> 1-hydroxy-2-naphthoate + NADH + H+ 1.2.1
–
1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + 2 H2O <=> 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + methylamine not assigned
 –
scyllo-Inositol + NADP+ <=> scyllo-inosose + NADPH + H+ 1.1.1
1.1.1.371 scyllo-inositol 2-dehydrogenase (NADP+)
–
–
o-Hydroxylaminobenzoate <=> 3-Hydroxyanthranilate 5.4.99
–
reduced_ferredoxin_[iron-sulfur]_cluster + N2 + ATP + H2O <=> oxidized_ferredoxin + H2 + NH3 + ADP + phosphate + H+ 1.18.6.1 nitrogenase
1.18.6.2 vanadium-dependent nitrogenase
1.19.6.1 nitrogenase (flavodoxin)
–
–
–
S-formylglutathione + H2O <=> H+ + formate + glutathione 3.1.1.56 methylumbelliferyl-acetate deacetylase
3.1.2.12 S-formylglutathione hydrolase
3.1.2.6 hydroxyacylglutathione hydrolase
–
–
–
N-methylmyosmine + H2O <=> 4-(methylamino)-1-(pyridin-3-yl)butan-1-one 1.5.3
–
paraoxon + H2O <=> diethyl_phosphate + 4-nitrophenol + H+ 3.1.1.1 carboxylesterase
3.1.1.2 arylesterase
3.1.1.25 1,4-lactonase
3.1.1.7 acetylcholinesterase
3.1.1.81 quorum-quenching N-acyl-homoserine lactonase
3.1.2.12 S-formylglutathione hydrolase
3.1.3.1 alkaline phosphatase
3.1.4.2 glycerophosphocholine phosphodiesterase
3.1.4.46 glycerophosphodiester phosphodiesterase
3.1.8.1 aryldialkylphosphatase
3.1.8.2 diisopropyl-fluorophosphatase
–
–
–
–
–
–
–
–
–
–
–
2-sulfoacetaldehyde <=> coenzyme_M not assigned
 –
2-dehydro-D-gluconate + ATP <=> H+ + 6-phospho-2-dehydro-D-gluconate + ADP 2.7.1.13 dehydrogluconokinase
2.7.1.45 2-dehydro-3-deoxygluconokinase
–
–
3-phospho-D-glycerate + H+ <=> D-ribulose_1,5-bisphosphate + CO2 + H2O 4.1.1.39 ribulose-bisphosphate carboxylase
–
L-aspartate + 2-oxoglutarate <=> oxaloacetate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2 alanine transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.75 cysteine-conjugate transaminase
2.6.1.78 aspartate---prephenate aminotransferase
2.6.1.79 glutamate---prephenate aminotransferase
–
–
–
–
–
–
–
–
–
–
L-fucose <=> L-Fuculose 5.3.1.25 L-fucose isomerase
5.3.1.3 D-arabinose isomerase
5.3.1.4 L-arabinose isomerase
–
–
–
Phthalate + O2 + NADH + H+ <=> cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ 1.14.12.7 phthalate 4,5-dioxygenase
–
(R)-3-methylitaconate <=> dimethylmaleate 5.3.3.6 methylitaconate Delta-isomerase
–
7-Mercaptoheptanoylthreonine + ATP <=> H+ + coenzyme_B + ADP 2.7.1
–
2-xylene + O2 + 2 reduced_ferredoxin_[iron-sulfur]_cluster + 2 H+ <=> 2-Methylbenzyl_alcohol + 2 oxidized_ferredoxin + H2O 1.14.15.26 toluene methyl-monooxygenase
–
3,5-Dichloro-2-methylmuconolactone <=> H+ + 3,5-Dichloro-2-methylmuconate 5.5.1.7 chloromuconate cycloisomerase
–
ethanol + 2 ferricytochrome_b5 <=> acetaldehyde + 2 ferricytochrome_b5 1.1.2.7 methanol dehydrogenase (cytochrome c)
–
sulfur + H2O + O2 <=> Sulfide + sulfite + H+ 1.13.11.55 sulfur oxygenase/reductase
–
carbazole + O2 + NADH + H+ <=> 2''-aminobiphenyl-2,3-diol + NAD+ 1.14.12.22 carbazole 1,9a-dioxygenase
–
3-Formylsalicylic_acid + O2 + H2O <=> 2-Hydroxyisophthalic_acid + H2O2 1.2.3
–
H+ + H2O + (S)-ureidoglycolate <=> NH3 + CO2 + glyoxylate 3.5.1.116 ureidoglycolate amidohydrolase
–
(3R)-hydroxybutyryl-CoA <=> crotonyl-CoA + H2O 4.2.1.119 enoyl-CoA hydratase 2
4.2.1.150 short-chain-enoyl-CoA hydratase
4.2.1.17 enoyl-CoA hydratase
4.2.1.55 3-hydroxybutyryl-CoA dehydratase
4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
–
–
–
–
–
1,3,4,6-tetrachloro-1,4-cyclohexadiene + H2O <=> 2,4,5-trichloro-2,5-cyclohexadiene-1-ol + Cl- 3.8.1.5 haloalkane dehalogenase
–
1-Methoxypyrene + O2 <=> 1-Methoxypyrene-6,7-oxide + H2O 1.14
–
2,4-dichloroaniline + 2 H+ <=> 4-chloroaniline + Hydrochloric_acid 1.97.1
–
5-Carboxymethyl-2-hydroxymuconate <=> (3E,5R)-5-carboxy-2-oxohept-3-enedioate 5.3.3.10 5-carboxymethyl-2-hydroxymuconate Delta-isomerase
–
Polyphosphate + beta-D-glucose <=> Polyphosphate + beta-D-glucose_6-phosphate 2.7.1.63 polyphosphate---glucose phosphotransferase
–
anthracene + NADH + H+ + O2 <=> cis-Anthracene_dihydrodiol + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
–
–
1-naphthalene_methanol + NAD+ <=> 1-naphthaldehyde + NADH + H+ 1.1.1.1 alcohol dehydrogenase
–
2,3,5-Trichloro-cis,cis-muconate <=> 2,5-Dichloro-carboxymethylenebut-2-en-4-olide + Hydrochloric_acid 5.5.1.7 chloromuconate cycloisomerase
–
sulfite + 2 ferricytochrome_c + H2O <=> sulfate + 2 ferricytochrome_c + 2 H+ 1.8.2.1 sulfite dehydrogenase (cytochrome)
1.8.3.1 sulfite oxidase
–
–
4-chlorobiphenyl + O2 + NADPH + H+ <=> cis-2,3-Dihydro-2,3-dihydroxy-4''-chlorobiphenyl + NADP+ 1.14.12.18 biphenyl 2,3-dioxygenase
–
2-naphthoic_acid <=> 5,6,7,8-Tetrahydro-2-naphthoic_acid not assigned
 –
nitrate + reduced_acceptor <=> nitrite + acceptor 1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]
1.7.7.2 ferredoxin---nitrate reductase
1.7.99
1.9.6.1 nitrate reductase (cytochrome)
–
–
–
–
H+ + melilotate + O2 + NADH <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+ 1.14.13.4 melilotate 3-monooxygenase
–
pyruvate + CoA + flavin + H+ <=> acetyl-CoA + CO2 + reduced_flavodoxin 1.2.7
1.2.7.1 pyruvate synthase
–
–
H2O + pyruvate + ATP <=> H+ + phosphate + phosphoenolpyruvate + AMP 2.7.1.40 pyruvate kinase
2.7.9.2 pyruvate, water dikinase
–
–
1-Hydroxypyrene-6,7-oxide <=> 1,6-dihydroxypyrene not assigned
 –
L-rhamnulose_1-phosphate <=> L-lactaldehyde + dihydroxyacetone_phosphate 4.1.2.17 L-fuculose-phosphate aldolase
4.1.2.19 rhamnulose-1-phosphate aldolase
–
–
LL-2,6-Diaminoheptanedioate <=> meso-2,6-diaminoheptanedioate 5.1.1.10 amino-acid racemase
5.1.1.7 diaminopimelate epimerase
–
–
4-Aminobenzoic_acid + O2 + NADPH + H+ <=> 4-Aminophenol + CO2 + H2O + NADP+ 1.14.13.27 4-aminobenzoate 1-monooxygenase
–
coenzyme_B + coenzyme_M + reduced_ferredoxin_[iron-sulfur]_cluster + CO2 <=> CoM-S-S-CoB + formate + oxidized_ferredoxin 1.8.98.6 formate:CoB-CoM heterodisulfide,ferredoxin reductase
–
4-Amino-2-hydroxylamino-6-nitrotoluene <=> 2,4-Diamino-6-nitrotoluene not assigned
 –
2-naphthalenemethanol + NAD+ <=> 2-naphthaldehyde + NADH 1.1.1.1 alcohol dehydrogenase
1.1.1.90 aryl-alcohol dehydrogenase
–
–
mono(2-hydroxyethyl)_terephthalate + H2O <=> terephthalate + ethylene_glycol + H+ 3.1.1.102 mono(ethylene terephthalate) hydrolase
–
alpha-D-glucose_6-phosphate <=> beta-D-glucose_6-phosphate 5.1.3.15 glucose-6-phosphate 1-epimerase
5.1.3.3 aldose 1-epimerase
5.3.1.9 glucose-6-phosphate isomerase
–
–
–
L-serine + acetyl-CoA <=> O-acetyl-L-serine + CoA 2.3.1.30 serine O-acetyltransferase
–
4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate <=> 2-Pyrone-4,6-dicarboxylate + methanol not assigned
 –
benzoate + NADPH + H+ + O2 <=> (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NADP+ 1.14.12.10 benzoate 1,2-dioxygenase
–
2,3-dehydroadipyl-CoA + acetyl-CoA <=> 3-oxo-5,6-dehydrosuberyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.223 3-oxo-5,6-didehydrosuberyl-CoA thiolase
–
–
protein_Npi-phospho-L-histidine + D-fructose <=> protein_L-histidine + D-Fructose_1-phosphate 2.7.1.202 protein-Npi-phosphohistidine---D-fructose phosphotransferase
–
2-carboxymethyl-3-hydroxyphenylpropionyl-CoA + NAD+ <=> Benzoylsuccinyl-CoA + NADH + H+ 1.1.1
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
–
–
catechol + O2 <=> H+ + cis,cis-muconate 1.13.11.1 catechol 1,2-dioxygenase
1.13.11.3 protocatechuate 3,4-dioxygenase
1.13.11.37 hydroxyquinol 1,2-dioxygenase
–
–
–
2-Methylbenzyl_alcohol + NAD+ <=> 2-Methylbenzaldehyde + NADH 1.1.1.90 aryl-alcohol dehydrogenase
–
D-lactate + NAD+ <=> pyruvate + NADH + H+ 1.1.1.27 L-lactate dehydrogenase
1.1.1.28 D-lactate dehydrogenase
1.1.1.345 D-2-hydroxyacid dehydrogenase (NAD+)
–
–
–
4,6-Dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+ <=> 4,6-Dichloro-3-methylcatechol + NADH + H+ 1.3.1
–
2-carboxymethyl-3-hydroxyphenylpropionyl-CoA <=> (E)-2-benzylidenesuccinyl-CoA + H2O 4.2.1
–
lactoyl-CoA <=> acryloyl-CoA + H2O 4.2.1
4.2.1.54 lactoyl-CoA dehydratase
–
–
benzo[a]pyrene + O2 + NADH + H+ <=> Benzo[a]pyrene-cis-7,8-dihydrodiol + NAD+ 1.14.12
–
4-Chlorophenol + O2 + NADPH + H+ <=> 4-Chlorocatechol + H2O + NADP+ 1.14.13.20 2,4-dichlorophenol 6-monooxygenase
1.14.13.7 phenol 2-monooxygenase (NADPH)
–
–
oxidized_ferredoxin + formylmethanofuran + H2O <=> reduced_ferredoxin_[iron-sulfur]_cluster + methanofuran + CO2 + H+ 1.2.7.12 formylmethanofuran dehydrogenase
–
ATP + CoA + 4-Chlorobenzoate <=> diphosphate + AMP + 4-chlorobenzoyl-CoA 6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.25 benzoate---CoA ligase
6.2.1.33 4-chlorobenzoate---CoA ligase
–
–
–
2,4-Dichlorobenzoate + CoA + ATP <=> 2,4-dichlorobenzoyl-CoA + AMP + diphosphate 6.2.1
–
2-phospho-D-glycerate <=> 3-phospho-D-glycerate 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
5.4.2.12 phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
–
–
O2 + H2O + pyridoxal <=> H+ + H2O2 + 4-pyridoxate 1.2.3.1 aldehyde oxidase
1.2.3.8 pyridoxal oxidase
–
–
2-dehydro-3-deoxy-L-rhamnonate <=> pyruvate + L-lactaldehyde 4.1.2.53 2-keto-3-deoxy-L-rhamnonate aldolase
–
2-aminobenzoyl-CoA <=> benzoyl-CoA + NH3 1.4
–
H2O + 2-(5-oxo-4,5-dihydrofuran-2-yl)acetic_acid <=> H+ + 3-oxoadipate 3.1.1.24 3-oxoadipate enol-lactonase
–
dihydroxyacetone_phosphate <=> methylglyoxal + phosphate 4.1.2.17 L-fuculose-phosphate aldolase
4.2.3.3 methylglyoxal synthase
5.3.1.1 triose-phosphate isomerase
–
–
–
glycolate + O2 <=> glyoxylate + H2O2 1.1.3.13 alcohol oxidase
1.1.3.15 (S)-2-hydroxy-acid oxidase
–
–
4-hydroxybutyrate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + AMP + diphosphate 6.2.1.40 4-hydroxybutyrate---CoA ligase (AMP-forming)
–
NH3 + L-glutamate + ATP <=> H+ + L-glutamine + ADP + phosphate 6.3.1.2 glutamine synthetase
–
2-oxoglutaryl-CoA + H2O <=> H+ + 2-oxoglutarate + CoA 3.1.2
–
alpha-D-glucose + ADP <=> alpha-D-glucose_6-phosphate + AMP 2.7.1.147 ADP-specific glucose/glucosamine kinase
–
Benzonitrile + H2O <=> Benzamide 4.2.1.84 nitrile hydratase
–
1-butanol + NADP+ <=> H+ + Butyraldehyde + NADPH 1.1.1
1.1.1.1 alcohol dehydrogenase
1.1.1.183 geraniol dehydrogenase (NADP+)
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.188 prostaglandin-F synthase
1.1.1.191 indole-3-acetaldehyde reductase (NADPH)
1.1.1.195 cinnamyl-alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.265 3-methylbutanal reductase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.72 glycerol dehydrogenase (NADP+)
1.1.1.91 aryl-alcohol dehydrogenase (NADP+)
–
–
–
–
–
–
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–
–
–
–
–
–
5,10-methenyltetrahydrofolate + H2O <=> 10-formyltetrahydrofolate + H+ 3.5.4.9 methenyltetrahydrofolate cyclohydrolase
–
Epoxyethane + H2O <=> ethylene_glycol 3.3.2.10 soluble epoxide hydrolase
3.3.2.9 microsomal epoxide hydrolase
–
–
1,2-dihydroxynaphthalene + O2 <=> H+ + 2-hydroxy-2H-chromene-2-carboxylate 1.13.11.56 1,2-dihydroxynaphthalene dioxygenase
–
Trichloroethylene + 2 H+ <=> cis-1,2-dichloroethene + Hydrochloric_acid 1.21.99.5 tetrachloroethene reductive dehalogenase
–
2,3,5-Trichlorodienelactone + H2O <=> 2,3,5-trichloromaleylacetate 3.1.1.45 carboxymethylenebutenolidase
–
Phenanthrene-1,2-oxide <=> 1-phenanthrol not assigned
 –
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+ <=> (R)-allantoin + CO2 not assigned
 –
dibenzo-p-dioxin + NADH + O2 <=> 2,2'',3-trihydroxybiphenyl_ether + NAD+ 1.14.12
1.14.12.18 biphenyl 2,3-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
–
–
–
2,3,5-trichloromaleylacetate + 2 NADPH + 2 H+ <=> 2,4-dichloro-3-oxohexanedioic_acid + 2 NADP+ + Hydrochloric_acid 1.3.1.32 maleylacetate reductase
–
trimethylamine + coenzyme_M <=> methyl-CoM + Dimethylamine 2.1.1.247 [methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.250 trimethylamine---corrinoid protein Co-methyltransferase
–
–
bithionol <=> acryloyl-CoA + H2O 4.2.1
4.2.1.116 3-hydroxypropionyl-CoA dehydratase
4.2.1.17 enoyl-CoA hydratase
–
–
–
Toluene + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> benzyl_alcohol + oxidized_ferredoxin + H2O 1.14.13
1.14.15.26 toluene methyl-monooxygenase
–
–
(S)-2-Hydroxy-2-(4-hydroxyphenyl)acetate + acceptor <=> 4-hydroxyphenylglyoxylate + reduced_acceptor 1.1.99.31 (S)-mandelate dehydrogenase
1.1.99.B9
–
–
melilotate + NAD+ <=> H+ + NADH + coumaric_acid 1.3.1.11 2-coumarate reductase
1.3.1.31 2-enoate reductase
–
–
H+ + 6-(ethylamino)-1,3,5-triazine-2,4-diol + H2O <=> cyanuric_acid + ethylamine 3.5.4
3.5.4.42 N-isopropylammelide isopropylaminohydrolase
3.5.99
–
–
–
1-hydroxy-2-naphthaldehyde + pyruvate <=> (3E)-4-(1-hydroxynaphthalen-2-yl)-2-oxobut-3-enoate + H2O 4.1.2
4.1.2.45 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
–
–
1,3-dicarboxyurea + H+ <=> allophanate + CO2 not assigned
 –
5alpha-androstane-3,17-dione + acceptor <=> 4-androstene-3,17-dione + reduced_acceptor 1.3.99.5 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
–
4,5-Chrysenedicarboxylate <=> 5-Chrysenecarboxylate + CO2 4.1.1
–
2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O <=> Isobutyrate + 2-hydroxy-2,4-pentadienoate 3.7.1
–
nitrite + H2O + NADP+ <=> H+ + nitrate + NADPH 1.7.1.1 nitrate reductase (NADH)
1.7.1.2 nitrate reductase [NAD(P)H]
1.7.1.3 nitrate reductase (NADPH)
–
–
–
tRNAMet + L-glutamate + ATP <=> Glu-tRNAGln + diphosphate + AMP 6.1.1.17 glutamate---tRNA ligase
6.1.1.24 glutamate---tRNAGln ligase
–
–
dihomocitrate <=> (-)-threo-iso(homo)2citrate 4.2.1.114 methanogen homoaconitase
–
Maleamate + H2O <=> Maleate + NH3 3.5.1.107 maleamate amidohydrolase
–
(3S)-citryl-CoA <=> oxaloacetate + acetyl-CoA 4.1.3.34 citryl-CoA lyase
–
an_alcohol + NAD+ <=> an_aldehyde + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.103 L-threonine 3-dehydrogenase
1.1.1.11 D-arabinitol 4-dehydrogenase
1.1.1.14 L-iditol 2-dehydrogenase
1.1.1.17 mannitol-1-phosphate 5-dehydrogenase
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.192 long-chain-alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.202 1,3-propanediol dehydrogenase
1.1.1.21 aldose reductase
1.1.1.244 methanol dehydrogenase
1.1.1.245 cyclohexanol dehydrogenase
1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase
1.1.1.306 S-(hydroxymethyl)mycothiol dehydrogenase
1.1.1.307 D-xylose reductase
1.1.1.6 glycerol dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.73 octanol dehydrogenase
1.1.1.77 lactaldehyde reductase
1.1.1.78 methylglyoxal reductase (NADH)
1.1.1.80 isopropanol dehydrogenase (NADP+)
1.1.1.B4
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L-ectoine + 2-oxoglutarate + O2 <=> 5-hydroxyectoine + succinate + CO2 1.14.11.55 ectoine hydroxylase
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carboxybiuret + H+ <=> Biuret + CO2 not assigned
 –
tetrahydrofolate + acetyl-CoA <=> 5-methyltetrahydrofolate + CoA + CO 2.1.1.258 5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
2.3.1.169 CO-methylating acetyl-CoA synthase
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H2O + 3,5-dibromo-4-hydroxybenzonitrile <=> NH3 + 3,5-dibromo-4-hydroxybenzoic_acid 3.5.5.1 nitrilase
3.5.5.6 bromoxynil nitrilase
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O-phospho-L-serine + H2O <=> L-serine + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.15 histidinol-phosphatase
3.1.3.16 protein-serine/threonine phosphatase
3.1.3.2 acid phosphatase
3.1.3.20 phosphoglycerate phosphatase
3.1.3.26 4-phytase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.3 phosphoserine phosphatase
3.1.3.48 protein-tyrosine-phosphatase
3.1.3.75 phosphoethanolamine/phosphocholine phosphatase
3.1.3.8 3-phytase
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2-amino-4,6-dinitrotoluene + 3 NADH + 3 H+ <=> 2,6-Diamino-4-nitrotoluene + 3 NAD+ + 2 H2O 1.7.1
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fluorene + O2 + NADH + H+ <=> 9-fluorenol + H2O + NAD+ 1.14.12
1.14.12.12 naphthalene 1,2-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
1.14.13
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formate + acetyl-CoA <=> pyruvate + CoA 2.3.1.54 formate C-acetyltransferase
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Toluene + O2 + NADH + H+ <=> (1S,2R)-3-Methylcyclohexa-3,5-diene-1,2-diol + NAD+ 1.14.12.11 toluene dioxygenase
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(-)-threo-iso(homo)3citrate + NAD+ <=> 2-Oxosuberate + CO2 + NADH 1.1.1
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NADP+ + 4-hydroxybutyrate <=> H+ + NADPH + succinate_semialdehyde 1.1.1
1.1.1.19 glucuronate reductase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.26 glyoxylate reductase
1.1.1.61 4-hydroxybutyrate dehydrogenase
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.B47
1.1.1.co
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2-chloro-4,6-diamino-s-triazine + H2O <=> 2-amino-4-chloro-6-hydroxy-1,3,5-triazine + NH3 3.5.4.45 melamine deaminase
3.8.1.8 atrazine chlorohydrolase
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trans-3-Chloroallyl_aldehyde + H2O <=> trans-3-Chloroacrylic_acid + 2 H+ 1.2.1.3 aldehyde dehydrogenase (NAD+)
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5-carboxymethyl-2-hydroxymuconate_semialdehyde + NAD+ + H2O <=> H+ + 5-Carboxymethyl-2-hydroxymuconate + NADH 1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
1.2.1.60 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
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theophylline + NADPH + O2 + H+ <=> 1-Methylxanthine + NADP+ + formaldehyde + H2O 1.14.13.179 methylxanthine N3-demethylase
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O-phospho-L-serine + 2-oxoglutarate <=> L-glutamate + 3-phosphohydroxypyruvate 2.6.1.52 phosphoserine transaminase
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oxalosuccinate + H+ <=> 2-oxoglutarate + CO2 1.1.1.42 isocitrate dehydrogenase (NADP+)
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epiandrosterone + NAD+ <=> 5alpha-androstane-3,17-dione + NADH 1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.210 3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase
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5-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate + NAD+ <=> 4-Fluorocatechol + NADH + CO2 + H+ 1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
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ATP + acetate <=> ADP + acetyl_phosphate 2.1.2.2 phosphoribosylglycinamide formyltransferase
2.7.2.1 acetate kinase
2.7.2.15 propionate kinase
2.7.2.2 carbamate kinase
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–
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formaldehyde + H2O <=> methanol + formate + H+ 1.2.98.1 formaldehyde dismutase
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L-fuconolactone + H2O <=> L-fuconate 3.1.1
–
6-Hydroxynicotinate + NADH + H+ + O2 <=> 2,5-dihydroxypyridine + NAD+ + CO2 + H2O 1.14.13.114 6-hydroxynicotinate 3-monooxygenase
–
methanol + coenzyme_M <=> methyl-CoM + H2O 2.1.1.246 [methyl-Co(III) methanol-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.90 methanol---corrinoid protein Co-methyltransferase
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3-Fluorobenzoate + NADH + O2 + H+ <=> 3-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate + NAD+ 1.14.12.10 benzoate 1,2-dioxygenase
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alpha-D-glucose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.9 glucose-6-phosphate isomerase
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benzoyl-CoA + reduced_acceptor <=> cyclohexa-1,5-diene-1-carbonyl-CoA + acceptor 1.3
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(2S)-lactyl-2-diphospho-5''-guanosine + coenzyme_F0 <=> GMP + coenzyme_F420-0 2.7.8.28 2-phospho-L-lactate transferase
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2-Hydroxy-2H-benzo[h]chromene-2-carboxylate <=> cis-4-(1''-Hydroxynaphth-2''-yl)-2-oxobut-3-enoate 5.1.2
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4-Methylbenzoate + O2 + NADH + H+ <=> cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NAD+ 1.14.12
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4-amino-2-nitrotoluene + 3 NADPH + 3 H+ <=> 2,4-Diaminotoluene + 3 NADP+ + 2 H2O 1.7.1
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2-Hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene)-but-2-enoic_acid + H2O <=> 2-Formyl-1-indanone + pyruvate not assigned
 –
1,2,3,5-Tetrahydroxybenzene + pyrogallol <=> 1,2,3,5-Tetrahydroxybenzene + phloroglucinol 1.97.1.2 pyrogallol hydroxytransferase
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N-hydroxyaniline <=> 2-Aminophenol 5.4.4.1 (hydroxyamino)benzene mutase
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2,4,5-trichloro-2,5-cyclohexadiene-1-ol <=> 2,5-dichlorophenol + Hydrochloric_acid not assigned
 –
Caffeine + NADPH + O2 + H+ <=> paraxanthine + NADP+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase
1.14.14.1 unspecific monooxygenase
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D-glyceraldehyde + H2O + oxidized_ferredoxin <=> D-glycerate + H+ + reduced_ferredoxin 1.2.7.5 aldehyde ferredoxin oxidoreductase
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5-oxopent-3-ene-1,2,5-tricarboxylate + H+ <=> 2-hydroxyhepta-2,4-dienedioate + CO2 4.1.1.68 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase
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formate + coenzyme_F420 + H+ <=> CO2 + reduced_coenzyme_F420 1.17.1.9 formate dehydrogenase
1.17.98.3 formate dehydrogenase (coenzyme F420)
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1,2-Dihydroxyfluorene + O2 <=> 2-Hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene)but-2-enoic_acid 1.13.11
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6-phospho-D-glucono-1,5-lactone + H2O <=> H+ + 6-phosphogluconate 3.1.1.31 6-phosphogluconolactonase
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4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP+ <=> 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+ 1.2.1.83 3-succinoylsemialdehyde-pyridine dehydrogenase
–
pyridoxine + O2 <=> pyridoxal + H2O2 1.1.3.12 pyridoxine 4-oxidase
1.4.3.5 pyridoxal 5'-phosphate synthase
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–
dihomocitrate + CoA + H+ <=> 2-oxoadipate + acetyl-CoA + H2O 2.3.3
4.1.3
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3-hydroxycinnamic_acid + O2 + NADH + H+ <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD+ 1.14.13.127 3-(3-hydroxyphenyl)propanoate hydroxylase
–
5-methylmaleylacetate + NADH + H+ <=> 2-methyl-3-oxoadipate + NAD+ 1.3.1.32 maleylacetate reductase
–
1-Hydroxy-6-methoxypyrene + CH3-R <=> 1,6-Dimethoxypyrene + R 2.1.1
–
4-nitrophenyl_phosphate + H2O <=> 4-nitrophenol + phosphate + H+ 3.1.16.1 spleen exonuclease
3.1.22.1 deoxyribonuclease II
3.1.3.1 alkaline phosphatase
3.1.3.10 glucose-1-phosphatase
3.1.3.16 protein-serine/threonine phosphatase
3.1.3.18 phosphoglycolate phosphatase
3.1.3.2 acid phosphatase
3.1.3.23 sugar-phosphatase
3.1.3.24 sucrose-phosphate phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.26 4-phytase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.3 phosphoserine phosphatase
3.1.3.31 nucleotidase
3.1.3.32 polynucleotide 3'-phosphatase
3.1.3.36 phosphoinositide 5-phosphatase
3.1.3.38 3-phosphoglycerate phosphatase
3.1.3.39 streptomycin-6-phosphatase
3.1.3.4 phosphatidate phosphatase
3.1.3.41 4-nitrophenylphosphatase
3.1.3.43 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase
3.1.3.44 [acetyl-CoA carboxylase]-phosphatase
3.1.3.48 protein-tyrosine-phosphatase
3.1.3.5 5'-nucleotidase
3.1.3.51 dolichyl-phosphatase
3.1.3.58 sugar-terminal-phosphatase
3.1.3.6 3'-nucleotidase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase
3.1.3.72 5-phytase
3.1.3.73 adenosylcobalamin/alpha-ribazole phosphatase
3.1.3.74 pyridoxal phosphatase
3.1.3.75 phosphoethanolamine/phosphocholine phosphatase
3.1.3.76 lipid-phosphate phosphatase
3.1.3.8 3-phytase
3.1.3.9 glucose-6-phosphatase
3.1.4.16 2',3'-cyclic-nucleotide 2'-phosphodiesterase
3.1.4.2 glycerophosphocholine phosphodiesterase
3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase
3.1.4.4 phospholipase D
3.1.4.46 glycerophosphodiester phosphodiesterase
3.1.7.6 farnesyl diphosphatase
3.11.1.1 phosphonoacetaldehyde hydrolase
3.6.1.11 exopolyphosphatase
3.6.1.5 apyrase
3.6.1.7 acylphosphatase
3.6.1.9 nucleotide diphosphatase
3.9.1.1 phosphoamidase
3.9.1.3 phosphohistidine phosphatase
5.4.2.6 beta-phosphoglucomutase
7.2.2.13 Na+/K+-exchanging ATPase
7.6.2.1 P-type phospholipid transporter
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cis-1,2-Dihydroxy-1,2-dihydro-8-carboxynaphthalene <=> 1,2-Dihydroxy-8-carboxynaphthalene 1.1
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Polyphosphate + alpha-D-glucose <=> Polyphosphate + alpha-D-glucose_6-phosphate 2.7.1.63 polyphosphate---glucose phosphotransferase
–
cis-1,3-dichloropropene + H2O <=> cis-3-Chloro-2-propene-1-ol + Hydrochloric_acid 3.8.1.5 haloalkane dehalogenase
–
9-fluorenol + NAD+ <=> 9-fluorenone + NADH + H+ 1.1.1.112 indanol dehydrogenase
1.1.1.256 fluoren-9-ol dehydrogenase
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3-hydroxybenzoate + O2 + NADPH + H+ <=> 3,4-dihydroxybenzoate + H2O + NADP+ 1.14.13.2 4-hydroxybenzoate 3-monooxygenase
1.14.13.23 3-hydroxybenzoate 4-monooxygenase
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xanthine + NAD+ + H2O <=> Urate + NADH + H+ 1.17.1.4 xanthine dehydrogenase
1.17.3.2 xanthine oxidase
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2-dehydro-3-deoxy-L-rhamnonate + NAD+ <=> 2,4-didehydro-3-deoxy-L-rhamnonate + NADH + H+ 1.1.1.401 2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+)
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9-fluorenol + NADP+ <=> 9-fluorenone + NADPH + H+ 1.1.1.112 indanol dehydrogenase
1.1.1.256 fluoren-9-ol dehydrogenase
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4,5-dihydroxypyrene + O2 <=> Phenanthrene-4,5-dicarboxylate 1.13.11
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(S)-malate + NADP+ <=> pyruvate + CO2 + NADPH 1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.39 malate dehydrogenase (decarboxylating)
1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
1.1.1.85 3-isopropylmalate dehydrogenase
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2,4-Diamino-6-nitrotoluene <=> 2,4,6-Triaminotoluene not assigned
 –
chloroethane + O2 + reduced_acceptor <=> acetaldehyde + Hydrochloric_acid + acceptor + H2O 1.13.12
1.14.99.39 ammonia monooxygenase
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2-hydroxy-2,4-pentadienoate + acetate <=> 2-hydroxy-6-oxohepta-2,4-dienoate + H2O 3.7.1.25 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase
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homogentisate + O2 + NADPH <=> 2,5-dihydroxybenzaldehyde + CO2 + NADP+ + H+ + H2O 4.1.1
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4-nitrophenyl + O2 + NADH <=> catechol + nitrite + NAD+ 1.14.12.23 nitroarene dioxygenase
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H+ + melamine + H2O <=> ammeline + NH3 3.5.4.45 melamine deaminase
3.8.1.8 atrazine chlorohydrolase
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4-Hydroxymethylsalicylate + O2 + NADH + H+ <=> 3,4-dihydroxybenzyl_alcohol + NAD+ + H2O + CO2 1.14.13.1 salicylate 1-monooxygenase
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2 bisphenol_A <=> 4-Methyl-2,4-bis-(p-hydroxyphenyl)pent-1-ene not assigned
 –
succinate + ITP + CoA <=> succinyl-CoA + IDP + phosphate 6.2.1.4 succinate---CoA ligase (GDP-forming)
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1,3,7-trimethyluric_acid + O2 + 2 H2O <=> 3,6,8-Trimethylallantoin + CO2 + H2O2 1.7.3.3 factor-independent urate hydroxylase
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2-hydroxyethyl-CoM <=> acetyl-CoA not assigned
 –
1,4,5,6-Tetrahydro-6-oxonicotinate + oxidized_ferredoxin <=> 6-Hydroxynicotinate + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.3.7.1 6-hydroxynicotinate reductase
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H+ + 3-dehydro-L-gulonate_6-phosphate <=> L-xylulose_5-phosphate + CO2 4.1.1.85 3-dehydro-L-gulonate-6-phosphate decarboxylase
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1,2-Dihydroxy-7-hydroxymethylnaphthalene + O2 <=> 2-Hydroxy-7-hydroxymethylchromene-2-carboxylate 1.13
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3-hydroxyaminophenol <=> 4-Aminocatechol 5.4.4.3 3-(hydroxyamino)phenol mutase
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2 1-Indanone + 2 CO2 <=> 2 2-Formyl-1-indanone + O2 not assigned
 –
O-acetyl-L-serine + Sulfide <=> L-cysteine + acetate + H+ 2.5.1.47 cysteine synthase
2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase
2.5.1.65 O-phosphoserine sulfhydrylase
4.2.1.22 cystathionine beta-synthase
4.2.1.50 pyrazolylalanine synthase
4.4.1.9 L-3-cyanoalanine synthase
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NADH + O2 + 4-hydroxybenzoate + H+ <=> NAD+ + CO2 + H2O + hydroquinone 1.14.13.114 6-hydroxynicotinate 3-monooxygenase
1.14.13.64 4-hydroxybenzoate 1-hydroxylase
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2-amino-4,6-dinitrotoluene <=> 2-Amino-4-nitrotoluene not assigned
 –
trimethylamine + O2 + NADPH <=> Trimethylamine_N-oxide + H2O + NADP+ 1.14.13.148 trimethylamine monooxygenase
1.14.13.8 flavin-containing monooxygenase
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2-oxoglutarate + CoA + NAD+ <=> succinyl-CoA + CO2 + NADH 1.2.1.ak
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
1.8.1.4 dihydrolipoyl dehydrogenase
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase
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homoisocitrate + NAD+ <=> 2-oxoadipate + CO2 + NADH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.42 isocitrate dehydrogenase (NADP+)
1.1.1.87 homoisocitrate dehydrogenase
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L-Fuculose_1-phosphate <=> L-lactaldehyde + dihydroxyacetone_phosphate 4.1.2.17 L-fuculose-phosphate aldolase
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Butyraldehyde + CoA + NAD+ <=> butyryl-CoA + NADH + H+ 1.2.1.10 acetaldehyde dehydrogenase (acetylating)
1.2.1.42 hexadecanal dehydrogenase (acylating)
1.2.1.57 butanal dehydrogenase
1.2.1.87 propanal dehydrogenase (CoA-propanoylating)
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butyryl-CoA + NAD+ <=> crotonyl-CoA + NADH + H+ 1.3.1.44 trans-2-enoyl-CoA reductase (NAD+)
1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)
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3-methylbenzaldehyde + NADP+ + H2O <=> 3-methylbenzoate + NADPH + H+ 1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.7 benzaldehyde dehydrogenase (NADP+)
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D-glucosaminate + protein_Npi-phospho-L-histidine <=> 6-phospho-D-glucosaminate + protein_L-histidine 2.7.1.203 protein-Npi-phosphohistidine---D-glucosaminate phosphotransferase
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methane + NADH + O2 + H+ <=> methanol + NAD+ + H2O 1.14.13.230 butane monooxygenase (soluble)
1.14.13.25 methane monooxygenase (soluble)
1.14.18.3 methane monooxygenase (particulate)
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Thiobenzamide_S,S-dioxide <=> Benzonitrile not assigned
 –
4-methylsalicylate + O2 + NADH + H+ <=> 4-methylcatechol + CO2 + H2O + NAD+ 1.14.13.1 salicylate 1-monooxygenase
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2-oxoglutarate + L-alanine <=> L-glutamate + pyruvate 2.6.1.1 aspartate transaminase
2.6.1.12 alanine---oxo-acid transaminase
2.6.1.2 alanine transaminase
2.6.1.37 2-aminoethylphosphonate---pyruvate transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.4 glycine transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.79 glutamate---prephenate aminotransferase
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cis-Anthracene_dihydrodiol + NAD+ <=> 1,2-Dihydroxyanthracene + NADH 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
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trimethylamine + 2 ferricytochrome_c + H2O <=> Trimethylamine_N-oxide + 2 ferricytochrome_c + 2 H+ 1.7.2.3 trimethylamine-N-oxide reductase
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1,4-dichlorobenzene + O2 + NADH + H+ <=> cis-1,2-Dihydroxy-3,6-dichlorocyclohexa-3,5-diene + NAD+ 1.14.12.26 chlorobenzene dioxygenase
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(3S,4R)-cis-3,4dihydroxy-3,4-dihydrofluorene <=> 3,4-Dihydroxyfluorene + 2 H+ 1.3.1
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2,4-Dichlorotoluene + NADH + O2 + H+ <=> 4,6-Dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+ 1.14.12
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5-methyltetrahydrofolate + NADP+ <=> 5,10-methylenetetrahydrofolate + NADPH + H+ 1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]
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4,5-dihydroxypyrene <=> Pyrene-4,5-dione not assigned
 –
(4S)-(+)-muconolactone <=> 2-(5-oxo-4,5-dihydrofuran-2-yl)acetic_acid 5.3.3.4 muconolactone Delta-isomerase
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malonate_semialdehyde + CoA + NADP+ <=> malonyl-CoA + NADPH + H+ 1.2.1.18 malonate-semialdehyde dehydrogenase (acetylating)
1.2.1.75 malonyl-CoA reductase (malonate semialdehyde-forming)
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2-chloro-cis,cis-muconate <=> trans-4-Carboxymethylenebut-2-en-4-olide + Hydrochloric_acid 5.5.1.7 chloromuconate cycloisomerase
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Glutarate + 2-oxoglutarate + O2 <=> (S)-2-hydroxyglutarate + succinate + CO2 1.14.11.64 glutarate dioxygenase
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cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized_ferredoxin + ADP + phosphate <=> benzoyl-CoA + reduced_ferredoxin_[iron-sulfur]_cluster + ATP + H2O 1.3.7.8 benzoyl-CoA reductase
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H+ + O2 + NADH + Benzene <=> NAD+ + cis-benzene_dihydrodiol 1.14.12.11 toluene dioxygenase
1.14.12.3 benzene 1,2-dioxygenase
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Dichloromethane + H2O <=> formaldehyde + Cl- + H+ 4.5.1.3 dichloromethane dehalogenase
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2 desethylatrazine + O2 <=> 2 2-chloro-4,6-diamino-s-triazine + 2 acetone 1.14.15
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protein_Npi-phospho-L-histidine + ascorbate <=> protein_L-histidine + L-ascorbate-6-phosphate 2.7.1.194 protein-Npi-phosphohistidine---L-ascorbate phosphotransferase
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Salicylaldehyde + NAD+ + H2O <=> salicylate + NADH + H+ 1.2.1
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.64 4-hydroxybenzaldehyde dehydrogenase (NAD+)
1.2.1.65 salicylaldehyde dehydrogenase
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3-methylbenzoate + NADH + O2 + H+ <=> 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ 1.14.12
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3,4-Dihydroxyphenanthrene + O2 <=> 2-Hydroxy-2H-benzo[h]chromene-2-carboxylate 1.13.11
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pyruvate + HCO3- + ATP <=> H+ + oxaloacetate + ADP + phosphate 6.4.1.1 pyruvate carboxylase
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1,2-Cyclohexanedione + H2O <=> 6-oxohexanoate + H+ 3.7.1.11 cyclohexane-1,2-dione hydrolase
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1-butanol + NAD+ <=> Butyraldehyde + NADH + H+ 1.1.1
1.1.1.1 alcohol dehydrogenase
1.1.1.103 L-threonine 3-dehydrogenase
1.1.1.105 all-trans-retinol dehydrogenase (NAD+)
1.1.1.192 long-chain-alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.202 1,3-propanediol dehydrogenase
1.1.1.21 aldose reductase
1.1.1.244 methanol dehydrogenase
1.1.1.245 cyclohexanol dehydrogenase
1.1.1.265 3-methylbutanal reductase
1.1.1.306 S-(hydroxymethyl)mycothiol dehydrogenase
1.1.1.6 glycerol dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.73 octanol dehydrogenase
1.1.1.76 (S,S)-butanediol dehydrogenase
1.1.1.B4
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–
–
phenylacetamide + H2O <=> phenylacetate + NH3 3.5.1.11 penicillin amidase
3.5.1.4 amidase
3.5.1.86 mandelamide amidase
–
–
–
nitrosobenzene + NADP+ + H2O <=> 4-nitrophenyl + NADPH + H+ 1.7.1.16 nitrobenzene nitroreductase
–
H2O + 4-Pyridoxolactone <=> H+ + 4-pyridoxate 3.1.1.27 4-pyridoxolactonase
–
1-Fluorocyclohexadiene-cis,cis-1,2-diol <=> catechol + F- not assigned
 –
nicotine_blue_leuco_form + NADP+ <=> nicotine_blue + NADPH + H+ 1.1.1.328 nicotine blue oxidoreductase
–
(S)-malate <=> fumarate + H2O 4.2.1.2 fumarate hydratase
4.2.1.34 (S)-2-methylmalate dehydratase
–
–
2,4-Dichlorophenoxyacetic_acid + 2-oxoglutarate + O2 <=> 2,4-Dichlorophenol + glyoxylate + succinate + CO2 1.14.11
–
theophylline + NADPH + O2 + H+ <=> 3-Methylxanthine + NADP+ + formaldehyde + H2O 1.14.13.178 methylxanthine N1-demethylase
–
formate + NAD+ <=> CO2 + NADH 1.17.1.10 formate dehydrogenase (NADP+)
1.17.1.9 formate dehydrogenase
–
–
D-ribulose_5-phosphate <=> D-xylulose_5-phosphate 5.1.3.1 ribulose-phosphate 3-epimerase
5.3.1.34 D-erythrulose 4-phosphate isomerase
–
–
1,2,3,4-tetrachlorobenzene + O2 + NADH + H+ <=> cis-Chlorobenzene_dihydrodiol + NAD+ 1.14.12
–
dihydrophloroglucinol + NADP+ <=> H+ + phloroglucinol + NADPH 1.3.1.57 phloroglucinol reductase
–
5-Oxopentanoate + H2O + NAD+ <=> Glutarate + NADH + H+ 1.2.1.20 glutarate-semialdehyde dehydrogenase
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
–
–
3-Hydroxy-2-methylpyridine-5-carboxylate + NADH + H+ + O2 <=> 2-(Acetamidomethylene)succinate + NAD+ 1.14.13.242 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase
–
formaldehyde + NAD+ + H2O <=> formate + NADH + H+ 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.21 glycolaldehyde dehydrogenase
1.2.1.22 lactaldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.32 aminomuconate-semialdehyde dehydrogenase
1.2.1.46 formaldehyde dehydrogenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.65 salicylaldehyde dehydrogenase
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
–
–
–
–
–
–
–
–
–
–
4-aminobutanoate + 2-oxoglutarate <=> succinate_semialdehyde + L-glutamate 2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2 alanine transaminase
2.6.1.22 (S)-3-amino-2-methylpropionate transaminase
2.6.1.29 diamine transaminase
2.6.1.48 5-aminovalerate transaminase
–
–
–
–
–
4-methylbenzyl_alcohol + NAD+ <=> H+ + 4-methylbenzaldehyde + NADH 1.1.1.21 aldose reductase
1.1.1.90 aryl-alcohol dehydrogenase
–
–
3-chloro-cis,cis-muconate <=> protoanemonin + Hydrochloric_acid + CO2 5.5.1.1 muconate cycloisomerase
–
D-glyceraldehyde_3-phosphate + NADP+ + H2O <=> H+ + 3-phospho-D-glycerate + NADPH 1.2.1.89 D-glyceraldehyde dehydrogenase (NADP+)
1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)
1.2.1.90 glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]
–
–
–
benzoate <=> 3-hydroxybenzoate not assigned
 –
2-Hydroxy-7-hydroxymethylchromene-2-carboxylate <=> 2-Hydroxy-4-hydroxymethylbenzalpyruvate 5.3.99
–
H+ + 5-carboxyvanillate <=> vanillic_acid + CO2 4.1.1
–
4-hydroxyphenyl_acetate + H2O <=> hydroquinone + acetate + H+ 3.1.1
3.1.1.1 carboxylesterase
3.1.1.2 arylesterase
–
–
–
beta-hexachlorocyclohexane + H2O <=> beta-2,3,4,5,6-Pentachlorocyclohexanol + Hydrochloric_acid 3.8.1.5 haloalkane dehalogenase
–
4-Methylene-2-oxoglutarate + H2O <=> 4-hydroxy-4-methyl-2-oxoglutarate 4.2.1
–
6-hydroxy-L-nicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2 1.5.3.5 (S)-6-hydroxynicotine oxidase
–
resorcinol + NADPH + O2 + H+ <=> Hydroxyquinol + NADP+ + H2O 1.14.13.219 resorcinol 4-hydroxylase (NADPH)
–
(S)-styrene_oxide <=> phenylacetaldehyde 5.3.99
5.3.99.7 styrene-oxide isomerase
–
–
2,4,5-T + O2 + NADH <=> 2,4,5-Trichlorophenol + glyoxylate + H2O + NAD+ 1.14.13
–
sulfite + Sulfide + menaquinone + H+ <=> thiosulfate + menaquinol 1.8.5.5 thiosulfate reductase (quinone)
–
3-hydroxypropionate + NADP+ <=> malonate_semialdehyde + NADPH + H+ 1.1.1
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.276 serine 3-dehydrogenase (NADP+)
1.1.1.298 3-hydroxypropionate dehydrogenase (NADP+)
–
–
–
–
dihydroxyacetone + ATP <=> H+ + dihydroxyacetone_phosphate + ADP 2.7.1.28 triokinase
2.7.1.29 glycerone kinase
2.7.1.30 glycerol kinase
–
–
–
cis-3,4-Phenanthrenedihydrodiol-4-carboxylate <=> 3,4-Dihydroxyphenanthrene + CO2 1.3
–
dihydrophloroglucinol + H2O <=> 3-Hydroxy-5-oxohexanoate + H+ 3.7.1
–
H+ + trihomocitrate + CoA <=> 2-oxopimelic_acid + acetyl-CoA + H2O 2.3.3
4.1.3
–
–
cis-4-(8-Hydroxypyren-7-yl)-2-oxobut-3-enoate <=> 10-Oxabenzo[def]chrysen-9-one + formate 4.1.3
–
Urate + NADH + H+ + O2 <=> 5-hydroxyisourate + NAD+ + H2O 1.14.13.113 FAD-dependent urate hydroxylase
–
citrate + CoA + ATP <=> (3S)-citryl-CoA + ADP + phosphate 6.2.1.18 citrate---CoA ligase
–
H2O + acceptor + N-Methyl-L-glutamate <=> L-glutamate + reduced_acceptor + formaldehyde 1.5.99.5 methylglutamate dehydrogenase
–
cis-4-carboxymethylenebut-2-en-4-olide + H2O <=> maleylacetate + H+ 3.1.1.45 carboxymethylenebutenolidase
–
2-Chloroethanol + ferricytochrome_b5 <=> Chloroacetaldehyde + ferricytochrome_b5 + H+ 1.1.2.7 methanol dehydrogenase (cytochrome c)
–
theophylline + NADH + O2 + H+ <=> 3-Methylxanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase
–
–
succinyl-CoA + acetyl-CoA <=> 3-oxoadipyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.174 3-oxoadipyl-CoA thiolase
–
–
4-hydroxyacetophenone + NADPH + O2 + H+ <=> 4-hydroxyphenyl_acetate + NADP+ + H2O 1.14.13.84 4-hydroxyacetophenone monooxygenase
–
Phenanthrene-4-carboxylate + O2 + NADH + H+ <=> cis-3,4-Phenanthrenedihydrodiol-4-carboxylate + NAD+ 1.14.12
–
2-Hydroxy-8-methylchromene-2-carboxylate <=> 2-Hydroxy-3-methylbenzalpyruvate 5.3.99
–
phenylacetate + ATP + CoA <=> phenylacetyl-CoA + AMP + diphosphate 6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.27 4-hydroxybenzoate---CoA ligase
6.2.1.30 phenylacetate---CoA ligase
–
–
–
fluorobenzene + NADH + H+ + O2 <=> 1-Fluorocyclohexadiene-cis,cis-1,2-diol + NAD+ 1.14.12
–
pyrene + O2 <=> Pyrene-4,5-oxide + H2O 1.14
–
(S)-4-Amino-5-oxopentanoate + NADP+ + tRNAMet <=> Glu-tRNAGln + NADPH + H+ 1.2.1.70 glutamyl-tRNA reductase
–
N2-acetyl-L-2,4-diaminobutanoate + H2O <=> L-2,4-diaminobutanoate + acetate 3.5.1.125 N2-acetyl-L-2,4-diaminobutanoate deacetylase
–
1,2,4-trichlorobenzene + O2 + NADH + H+ <=> 3,4,6-Trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+ 1.14.12.26 chlorobenzene dioxygenase
–
1,2-Dihydroxy-8-carboxynaphthalene + O2 <=> 2-Carboxy-2-hydroxy-8-carboxychromene 1.13
–
tetrachlorocatechol + O2 <=> cis,cis-tetrachloromuconic_acid 1.13.11.1 catechol 1,2-dioxygenase
–
3-fluorocatechol + O2 <=> 2-fluoro-cis,cis-muconate + H+ 1.13.11.1 catechol 1,2-dioxygenase
1.13.11.M6
–
–
2,6-dibromo-p-hydroquinone <=> 2-bromomaleylacetate not assigned
 –
NAD+ + 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate <=> CO2 + NADH + 3-methylcatechol 1.3.1.68 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase
–
2-Amino-4-nitrotoluene + 3 NADH + 3 H+ <=> 2,4-Diaminotoluene + 3 NAD+ + 2 H2O 1.7.1
–
H+ + 2,3-Dihydroxybenzoate <=> CO2 + catechol 4.1.1.103 gamma-resorcylate decarboxylase
4.1.1.46 o-pyrocatechuate decarboxylase
4.1.1.91 salicylate decarboxylase
–
–
–
isocitrate <=> glyoxylate + succinate 4.1.3.1 isocitrate lyase
–
4-chlorobenzoyl-CoA + Cl- + NADP+ <=> 2,4-dichlorobenzoyl-CoA + NADPH 1.21.1.2 2,4-dichlorobenzoyl-CoA reductase
–
trans-3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]-acrylic_acid + NAD+ <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH + H+ 1.3.1.87 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase
–
L-lysine + O2 <=> 5-Aminopentanamide + CO2 + H2O 1.13.12.2 lysine 2-monooxygenase
–
(S)-2-Hydroxy-2-(4-hydroxyphenyl)acetate + O2 + H+ <=> 4-hydroxybenzaldehyde + CO2 + H2O2 1.1.3.19 4-hydroxymandelate oxidase (decarboxylating)
–
3-vinylcatechol + O2 <=> 2-Hydroxy-6-oxoocta-2,4,7-trienoate 1.13.11.2 catechol 2,3-dioxygenase
–
glutaryl-CoA + acceptor <=> glutaconyl-CoA + reduced_acceptor 1.3.99.32 glutaryl-CoA dehydrogenase (acceptor)
–
3-hydroxy-cis,cis-muconate <=> maleylacetate 0.0.0.0
–
4-[2-(5-Carboxy-2-hydroxy-3-methoxyphenyl)-2-oxoethylidene]-2-hydroxy-2-pentenedioate + H2O <=> 5-Carboxyvanillic_acid + 4-Methylene-2-oxoglutarate not assigned
 –
(1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+ <=> 3,4-dihydroxybenzoate + CO2 + NADH 1.3.1.53 (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase
–
phenylacetonitrile + H2O <=> phenylacetamide 4.2.1.84 nitrile hydratase
–
4-(hydroxymethyl)benzenesulfonate + NAD+ <=> 4-formylbenzenesulfonate + H+ + NADH 1.1.1.257 4-(hydroxymethyl)benzenesulfonate dehydrogenase
–
3-chlorocatechol + O2 <=> H+ + 2-chloro-cis,cis-muconate 1.13.11
1.13.11.1 catechol 1,2-dioxygenase
1.13.11.M6
–
–
–
4-methylcatechol + O2 <=> 2-Hydroxy-5-methyl-cis,cis-muconic_semialdehyde 1.13.11.2 catechol 2,3-dioxygenase
–
2-hydroxymethylglutarate + NAD+ <=> (S)-2-formylglutarate + NADH + H+ 1.1.1.291 2-hydroxymethylglutarate dehydrogenase
–
5-methoxygallic_acid + O2 <=> H+ + 2-Pyrone-4,6-dicarboxylate + methanol 1.13.11
1.13.11.8 protocatechuate 4,5-dioxygenase
–
–
pimeloyl-CoA + NAD+ <=> H+ + NADH + 6-carboxyhex-2-enoyl-CoA 1.3.1.62 pimeloyl-CoA dehydrogenase
–
3,4,6-trichlorocatechol + O2 <=> 2,3,5-Trichloro-cis,cis-muconate + H+ 1.13.11
1.13.11.M6
–
–
4-fluorobenzoyl-CoA + H2O <=> 4-hydroxybenzoyl-CoA + F- 3.8.1.7 4-chlorobenzoyl-CoA dehalogenase
–
H+ + 2,5-Dihydroxybenzoate <=> CO2 + hydroquinone 4.1.1.46 o-pyrocatechuate decarboxylase
4.1.1.62 gentisate decarboxylase
–
–
pyridoxamine + 2-oxoglutarate <=> pyridoxal + D-glutamate 2.6.1.31 pyridoxamine---oxaloacetate transaminase
2.6.1.54 pyridoxamine-phosphate transaminase
–
–
2-hydroxy-1,4-benzoquinone + NADH + H+ <=> Hydroxyquinol + NAD+ 1.6.5.7 2-hydroxy-1,4-benzoquinone reductase
1.8.1.4 dihydrolipoyl dehydrogenase
–
–
(3S)-3-hydroxyadipyl-CoA <=> 2,3-dehydroadipyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
–
acetyl-CoA + corrinoid <=> CoA + CO + methylcorrinoid_protein 2.3.1.169 CO-methylating acetyl-CoA synthase
–
beta-methylmalyl-CoA <=> glyoxylate + propionyl-CoA 4.1.3.24 malyl-CoA lyase
–
hydroquinone + O2 + NADPH <=> Hydroxyquinol + NADP+ + H2O 1.14.13
1.14.13.7 phenol 2-monooxygenase (NADPH)
1.14.14.20 phenol 2-monooxygenase (FADH2)
–
–
–
sulfite + O2 + H2O <=> H2O2 + sulfate 1.8.3.1 sulfite oxidase
–
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA <=> 2-oxepin-2(3H)-ylideneacetyl-CoA 5.3.3.18 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase
–
pyridoxamine + oxaloacetate <=> pyridoxal + L-aspartate 2.6.1.31 pyridoxamine---oxaloacetate transaminase
–
cis-1,2-Dihydroxy-1,2-dihydro-8-methylnaphthalene + NAD+ <=> 1,2-Dihydroxy-8-methylnaphthalene + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
–
cis-3-[2,2-Dichloro-1-(4-chlorophenyl)vinyl]-6-chlorocyclohexa-3,5-diene-1,2-diol + NAD+ <=> 1,1-Dichloro-2-(dihydroxy-4''-chlorophenyl)-2-(4''-chlorophenyl)ethylene + NADH + H+ 1.3.1
–
1,2,3,4-tetrahydronaphthalene <=> 5,6,7,8-Tetrahydro-2-naphthoic_acid not assigned
 –
citrate <=> cis-aconitate + H2O 4.2.1.117 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
4.2.1.3 aconitate hydratase
–
–
glutaryl-CoA + flavin <=> crotonyl-CoA + CO2 + reduced_flavodoxin 1.3.8.6 glutaryl-CoA dehydrogenase (ETF)
–
p-Cresol + H2O + oxidized_azurin <=> 4-hydroxybenzaldehyde + azurin + H+ 1.17.9.1 4-methylphenol dehydrogenase (hydroxylating)
–
2 acetophenone + O2 <=> 2 2-hydroxyacetophenone 1.14.12.12 naphthalene 1,2-dioxygenase
–
4-hydroxy-2-oxopentanoate <=> pyruvate + acetaldehyde 4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolase
4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase
4.1.3.39 4-hydroxy-2-oxovalerate aldolase
4.1.3.43 4-hydroxy-2-oxohexanoate aldolase
–
–
–
–
H+ + 2-Oxosuberate <=> pimelic_semialdehyde + CO2 not assigned
 –
S-adenosyl-L-methionine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil <=> coenzyme_F0 + 5''-deoxyadenosine + L-methionine + NH3 + H+ 4.3.1.32 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
–
1,2-Dihydroxyanthracene + O2 <=> 4-(3-Hydroxy-2-naphthyl)-2-oxobut-3-enoic_acid 1.13.11
–
(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+ <=> 1,2-dihydroxynaphthalene + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
–
cis-1,2-Dihydroxy-1,2-dihydro-7-hydroxymethylnaphthalene + NAD+ <=> 1,2-Dihydroxy-7-hydroxymethylnaphthalene + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
–
H+ + 2-hydroxy-5-methylquinone + NADH <=> 2,4,5-Trihydroxytoluene + NAD+ 1.1.1
–
cis-benzene_dihydrodiol + NAD+ <=> catechol + NADH + H+ 1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.3.1.119 chlorobenzene dihydrodiol dehydrogenase
1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
–
–
–
–
–
–
H+ + N-cyclopropylammelide + H2O <=> cyanuric_acid + cyclopropylamine 3.5.4
3.5.4.42 N-isopropylammelide isopropylaminohydrolase
–
–
nitrite + azurin <=> NO + oxidized_azurin 1.7.2.1 nitrite reductase (NO-forming)
–
cis-4-(7-Hydroxtpyren-8-yl)-2-oxobut-3-enoate <=> 7,8-Dihydropyrene-8-carboxylate not assigned
 –
ATP + acetyl-CoA + HCO3- <=> ADP + phosphate + malonyl-CoA + H+ 6.4.1.2 acetyl-CoA carboxylase
6.4.1.3 propionyl-CoA carboxylase
6.4.1.4 methylcrotonoyl-CoA carboxylase
–
–
–
acetyl-CoA + 5,6,7,8-tetrahydromethanopterin <=> CoA + 5-Methyl-5,6,7,8-tetrahydromethanopterin + CO not assigned
 –
2,4-dinitrotoluene + 3 NADH + 3 H+ <=> 2-Amino-4-nitrotoluene + 3 NAD+ + 2 H2O 1.7.1
–
6-phosphogluconate + NADP+ <=> D-ribulose_5-phosphate + CO2 + NADPH 1.1.1.351 phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
–
–
Sulfide + 2 ferricytochrome_c <=> sulfur + 2 ferricytochrome_c + 2 H+ 1.8.2.3 sulfide-cytochrome-c reductase (flavocytochrome c)
–
N6-acetyl-N6-hydroxy-L-lysine + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + ATP <=> aerobactin + AMP + diphosphate + H+ 6.3.2.39 aerobactin synthase
–
L-rhamnose <=> keto-L-rhamnulose 5.3.1.14 L-rhamnose isomerase
5.3.1.20 ribose isomerase
–
–
phenanthrene-9,10-oxide <=> 9-Phenanthrol not assigned
 –
acceptor + glycolate <=> reduced_acceptor + glyoxylate 1.1.3.15 (S)-2-hydroxy-acid oxidase
1.1.99.14 glycolate dehydrogenase
–
–
cyclopropanecarboxyl-CoA <=> crotonyl-CoA 5.5.1
–
coenzyme_F420 + H2 <=> reduced_coenzyme_F420 1.12.98.1 coenzyme F420 hydrogenase
–
2,3,6-Trihydroxypyridine + O2 + H+ <=> Maleamate + 2 H+ + CO2 not assigned
 –
1-Methylxanthine + NADH + O2 + H+ <=> xanthine + NAD+ + formaldehyde + H2O 1.14.13.178 methylxanthine N1-demethylase
–
NO + NH3 <=> N2O + H2O 1.7.1.14 nitric oxide reductase [NAD(P)+, nitrous oxide-forming]
–
coenzyme_B + coenzyme_M + oxidized_ferredoxin <=> CoM-S-S-CoB + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.8.7.3 ferredoxin:CoB-CoM heterodisulfide reductase
–
1-hydroxypyrene + O2 <=> 1-Hydroxypyrene-7,8-oxide + H2O 1.14
–
3-oxo-3-phenylpropionic_acid + CoA + ATP <=> benzoylpropionyl-CoA + AMP + diphosphate 6.2.1
–
dihomocitrate <=> (Z)-pent-1-ene-1,2,5-tricarboxylate + H2O 4.2.1.114 methanogen homoaconitase
–
5-aminolevulinate <=> H+ + H2O + porphobilinogen 4.2.1.24 porphobilinogen synthase
–
fluorene + O2 + NADH + H+ <=> (3S,4R)-cis-3,4dihydroxy-3,4-dihydrofluorene + NAD+ 1.14.12
1.14.12.12 naphthalene 1,2-dioxygenase
–
–
4-Isopropylbenzyl_alcohol + NAD+ <=> cuminaldehyde + NADH + H+ 1.1.1.90 aryl-alcohol dehydrogenase
1.1.1.M33
–
–
phosphate + beta-D-fructose_6-phosphate <=> H2O + D-erythrose_4-phosphate + acetyl_phosphate 4.1.2.22 fructose-6-phosphate phosphoketolase
–
cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate + NAD+ <=> H+ + 2,3-Dihydroxy-p-cumate + NADH 1.3.1.58 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase
–
L-serine + tetrahydrofolate <=> glycine + 5,10-methylenetetrahydrofolate + H2O 2.1.2.1 glycine hydroxymethyltransferase
–
L-Fuculose + ATP <=> H+ + L-Fuculose_1-phosphate + ADP 2.7.1.51 L-fuculokinase
–
2-Chloroethanol + 2 ferricytochrome_c <=> Chloroacetaldehyde + 2 ferricytochrome_c + 2 H+ 1.1.2.8 alcohol dehydrogenase (cytochrome c)
–
5,10-methylenetetrahydromethanopterin + H2O <=> formaldehyde + 5,6,7,8-tetrahydromethanopterin 4.2.1.147 5,6,7,8-tetrahydromethanopterin hydro-lyase
–
acetyl-CoA <=> acetoacetyl-CoA + CoA 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.38 [acyl-carrier-protein] S-acetyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase
–
–
–
–
–
2,4,6-Triaminotoluene <=> 2,4,6-Trihydroxytoluene not assigned
 –
2,5-dichloro-p-quinol + glutathione <=> H+ + chlorohydroquinone + GSSG + Cl- 2.5.1
–
2,2,3-trichlorooxirane <=> formate not assigned
 –
N4-acetyl-L-2,4-diaminobutanoate <=> L-ectoine + H2O 4.2.1.108 ectoine synthase
–
oxamate + H2O <=> oxalate + NH3 3.5.1.126 oxamate amidohydrolase
–
H2O + trithionate <=> H+ + sulfate + thiosulfate 3.12.1.1 trithionate hydrolase
–
Acrylamide <=> acrylonitrile + H2O 4.2.1.66 cyanide hydratase
4.2.1.84 nitrile hydratase
–
–
acetaldehyde + H2O + NAD+ <=> acetate + NADH + H+ 1.17.1.4 xanthine dehydrogenase
1.2.1.10 acetaldehyde dehydrogenase (acetylating)
1.2.1.18 malonate-semialdehyde dehydrogenase (acetylating)
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.21 glycolaldehyde dehydrogenase
1.2.1.22 lactaldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase
1.2.1.32 aminomuconate-semialdehyde dehydrogenase
1.2.1.36 retinal dehydrogenase
1.2.1.39 phenylacetaldehyde dehydrogenase
1.2.1.41 glutamate-5-semialdehyde dehydrogenase
1.2.1.46 formaldehyde dehydrogenase
1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenase
1.2.1.48 long-chain-aldehyde dehydrogenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.65 salicylaldehyde dehydrogenase
1.2.1.69 fluoroacetaldehyde dehydrogenase
1.2.1.8 betaine-aldehyde dehydrogenase
1.2.1.85 2-hydroxymuconate-6-semialdehyde dehydrogenase
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
1.2.1.99 4-(gamma-glutamylamino)butanal dehydrogenase
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
L-ascorbate-6-phosphate + H2O <=> 3-dehydro-L-gulonate_6-phosphate 3.1.1
–
3-oxoadipate + NAD+ <=> maleylacetate + NADH + H+ 1.3.1.32 maleylacetate reductase
–
(R)-2-benzylsuccinyl-CoA + flavin <=> (E)-2-benzylidenesuccinyl-CoA + reduced_flavodoxin 1.3.8.3 (R)-benzylsuccinyl-CoA dehydrogenase
–
(S)-Mandelate + tetrahydropteridine + O2 <=> (S)-2-Hydroxy-2-(4-hydroxyphenyl)acetate + a_4a-hydroxy-5,6,7,8-tetrahydropteridine 1.14.16.6 mandelate 4-monooxygenase
–
4-methyl-5-nitrocatechol + O2 + NADH <=> H+ + 2-hydroxy-5-methylquinone + NAD+ + nitrite + H2O 1.14.13.210 4-methyl-5-nitrocatechol 5-monooxygenase
–
5-methyltetrahydrofolate + corrinoid + H+ <=> methylcorrinoid_protein + tetrahydrofolate 2.1.1.258 5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
–
3-Hydroxybenzaldehyde + NAD+ + H2O <=> 3-hydroxybenzoate + NADH + H+ 1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.64 4-hydroxybenzaldehyde dehydrogenase (NAD+)
1.2.1.65 salicylaldehyde dehydrogenase
1.2.1.67 vanillin dehydrogenase
1.2.1.7 benzaldehyde dehydrogenase (NADP+)
–
–
–
–
–
–
–
–
benzoyl_phosphate + H2O <=> benzoate + phosphate 3.6.1.7 acylphosphatase
–
NAD+ + cis-1,2-dihydro-3-ethylcatechol <=> H+ + NADH + 3-ethylcatechol 1.3.1.66 cis-dihydroethylcatechol dehydrogenase
–
4-oxo-4-(pyridin-3-yl)butanoate + H2O + acceptor <=> 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + reduced_acceptor 1.5.99
–
9-fluorenone + O2 + 2 NADPH <=> 3,4-Dihydroxy-3,4-dihydro-9-fluorenone + 2 NADP+ 1.14.12
–
hydrazine + H2O + 3 ferricytochrome_c <=> NO + NH3 + 3 ferricytochrome_c 1.7.2.7 hydrazine synthase
–
1-methylnaphthalene + O2 + NADH + H+ <=> 1-naphthalene_methanol + NAD+ + H2O 1.14.13
–
oxaloacetate + GTP <=> CO2 + phosphoenolpyruvate + GDP 4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)
4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)
–
–
2,4-Dihydroxyhept-2-enedioate <=> succinate_semialdehyde + pyruvate 4.1.2
4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolase
–
–
(2R)-3-sulfolactate + NAD+ <=> H+ + 3-sulfopyruvate + NADH 1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
–
–
–
S-hydroxymethylglutathione <=> formaldehyde + glutathione 1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase
4.4.1.22 S-(hydroxymethyl)glutathione synthase
–
–
2,4,6-Trichlorophenol + O2 + FADH2 <=> 2,6-dichloroquinone + Cl- + H2O + FAD + H+ 1.14.14.173 2,4,6-trichlorophenol monooxygenase
–
D-glyceraldehyde + acceptor + H2O <=> D-glycerate + reduced_acceptor + H+ 1.2.99.8 glyceraldehyde dehydrogenase (FAD-containing)
–
H+ + Cinnamic_acid + O2 + NADPH <=> H2O + NADP+ + coumaric_acid 1.14.13.14 trans-cinnamate 2-monooxygenase
1.14.14.91 trans-cinnamate 4-monooxygenase
–
–
2-hydroxycyclohexane-1-carbonyl-CoA + NAD+ <=> H+ + 2-ketocyclohexane-1-carboxyl-CoA + NADH 1.1.1
–
4-hydroxy-2-oxopentanoate <=> 2-oxopent-4-enoate + H2O 4.2.1.80 2-oxopent-4-enoate hydratase
–
(RS)-nicotine + O2 <=> N-methylmyosmine + H2O2 1.5.3
–
3''-phosphoadenylyl-sulfate + H2O <=> adenosine_5''-phosphosulfate + phosphate 3.1.3.57 inositol-1,4-bisphosphate 1-phosphatase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase
–
–
cis-Chlorobenzene_dihydrodiol + NAD+ <=> tetrachlorocatechol + NADH + H+ 1.3.1
–
Cyclohexanol + NAD+ <=> cyclohexanone + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.112 indanol dehydrogenase
1.1.1.163 cyclopentanol dehydrogenase
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.243 carveol dehydrogenase
1.1.1.245 cyclohexanol dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
–
–
–
–
–
–
–
L-2,4-diaminobutanoate + acetyl-CoA <=> H+ + N4-acetyl-L-2,4-diaminobutanoate + CoA 2.3.1.178 diaminobutyrate acetyltransferase
–
L-homoserine + NADP+ <=> L-aspartate_4-semialdehyde + NADPH + H+ 1.1.1.3 homoserine dehydrogenase
–
2,4-dichloro-cis,cis-muconate <=> trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide + Hydrochloric_acid 5.5.1.11 dichloromuconate cycloisomerase
–
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 <=> H+ + 4,5-9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic_acid 1.13.11.25 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
–
2,3-dihydroxynaphthalene <=> salicylate not assigned
 –
3,5-Dichloro-2-methylmuconate <=> 2-Chloro-5-methyl-cis-dienelactone + Hydrochloric_acid 5.5.1.7 chloromuconate cycloisomerase
–
2-hydroxymuconate-6-semialdehyde + H2O + NAD+ <=> 2-hydroxy-2,4-hexadienedioate + NADH + H+ 1.2.1.32 aminomuconate-semialdehyde dehydrogenase
1.2.1.85 2-hydroxymuconate-6-semialdehyde dehydrogenase
–
–
2-Naphtylmethylsuccinic_acid + succinyl-CoA <=> Naphthyl-2-methyl-succinyl-CoA + succinate 2.8.3
–
3-oxopimeloyl-CoA + CoA <=> glutaryl-CoA + acetyl-CoA 2.3.1
2.3.1.16 acetyl-CoA C-acyltransferase
–
–
pyruvate + CoA + oxidized_ferredoxin <=> acetyl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.1 pyruvate synthase
1.2.7.11 2-oxoacid oxidoreductase (ferredoxin)
1.2.7.7 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
–
–
–
2,4-Dihydroxylamino-6-nitrotoluene + NADPH + H+ <=> 4-Amino-2-hydroxylamino-6-nitrotoluene + NADP+ + H2O 1.7.1
–
(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> H+ + anthranilate + 2-hydroxy-2,4-pentadienoate 3.7.1.13 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase
–
2-naphthalenemethanol + O2 + NADH + H+ <=> cis-1,2-Dihydroxy-1,2-dihydro-7-hydroxymethylnaphthalene + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase
–
2-amino-4,6-dinitrotoluene + 3 NADH + 3 H+ <=> 2,4-Diamino-6-nitrotoluene + 3 NAD+ + 2 H2O 1.7.1
–
3-Phenylpropionic_acid + NAD+ <=> trans-cinnamate + NADH + H+ 1.3.1.31 2-enoate reductase
–
2-Methylbenzaldehyde + NADP+ + H2O <=> 2-Methylbenzoate + NADPH + H+ 1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.7 benzaldehyde dehydrogenase (NADP+)
–
–
acetyl-CoA + tetrahydrosarcinapterin <=> CoA + 5-methyltetrahydrosarcinapterin + CO not assigned
 –
succinyl-CoA + acetate <=> succinate + acetyl-CoA 2.8.3.1 propionate CoA-transferase
2.8.3.18 succinyl-CoA:acetate CoA-transferase
2.8.3.8 acetate CoA-transferase
–
–
–
D-fructose + ATP <=> H+ + D-Fructose_1-phosphate + ADP 2.7.1.11 6-phosphofructokinase
2.7.1.3 ketohexokinase
–
–
3-hydroxyaminophenol <=> aminohydroquinone 5.4.4.3 3-(hydroxyamino)phenol mutase
–
(2S)-ethylmalonyl-CoA + NADP+ <=> crotonyl-CoA + CO2 + NADPH 1.3.1.85 crotonyl-CoA carboxylase/reductase
–
(S)-4-Amino-5-oxopentanoate <=> 5-aminolevulinate 5.4.3.8 glutamate-1-semialdehyde 2,1-aminomutase
–
2-Fluorobenzoate + NADH + H+ + O2 <=> 6-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate + NAD+ 1.14.12.10 benzoate 1,2-dioxygenase
–
pyruvate + CoA + NAD+ <=> acetyl-CoA + CO2 + NADH 1.2.1.aj
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
1.8.1.4 dihydrolipoyl dehydrogenase
2.3.1.12 dihydrolipoyllysine-residue acetyltransferase
–
–
–
–
–
–
anthracene + O2 + 2 H+ + 2 e- <=> Anthracene-9,10-dihydrodiol 1.14
–
2,5-Dihydroxybenzoate + H2O2 <=> 2,5-dihydroxybenzaldehyde + O2 + H2O 1.2.3.1 aldehyde oxidase
–
beta-D-fructose_6-phosphate + ADP <=> H+ + D-fructose_1,6-bisphosphate + AMP 2.7.1.146 ADP-specific phosphofructokinase
–
terephthalate + H2O <=> benzoate + HCO3- not assigned
 –
1-Indanone + NADPH + H+ + O2 <=> dihydrocoumarin + NADP+ + H2O 1.14.12
1.14.13.84 4-hydroxyacetophenone monooxygenase
1.14.13.92 phenylacetone monooxygenase
–
–
–
scyllo-Inositol + NAD+ <=> scyllo-inosose + NADH + H+ 1.1.1.18 inositol 2-dehydrogenase
1.1.1.370 scyllo-inositol 2-dehydrogenase (NAD+)
–
–
theophylline + NADH + O2 + H+ <=> 1-Methylxanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase
–
–
L-homoserine + NAD+ <=> L-aspartate_4-semialdehyde + NADH + H+ 1.1.1.3 homoserine dehydrogenase
–
Caffeine + NADH + O2 + H+ <=> Theobromine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase
–
–
cis-aconitate + H2O <=> isocitrate 4.2.1.3 aconitate hydratase
–
phenanthrene + O2 + NADH + H+ <=> phenanthrene-9,10-oxide + H2O + NAD+ 1.14.13
–
trans-3-chloroacrylate <=> malonate_semialdehyde + Cl- 3.8.1
5.3.2.1 phenylpyruvate tautomerase
–
–
9,10-dihydroxy-benzo(a)pyrene + O2 <=> cis-4-(8-Hydroxypyren-7-yl)-2-oxobut-3-enoate 1.13.11
–
2-Chlorobenzoate + O2 + NADH + H+ <=> catechol + Cl- + CO2 + NAD+ 1.14.12.13 2-halobenzoate 1,2-dioxygenase
–
5,6-Dichloro-1,3-cyclohexadiene <=> chlorobenzene + Cl- + H+ not assigned
 –
carbazole + O2 + NADPH + H+ <=> 2''-aminobiphenyl-2,3-diol + NADP+ 1.14.12.22 carbazole 1,9a-dioxygenase
–
6-hydroxyhexanoate + NADP+ <=> 6-oxohexanoate + NADPH + H+ 1.1.1.2 alcohol dehydrogenase (NADP+)
–
4-carboxy-2-hydroxy-cis,cis-muconate_6-semialdehyde <=> 4-carboxy-2-hydroxy-cis,cis-muconate_6-semialdehyde not assigned
 –
4-Hydroxyphenyl-4-hydroxybenzoate + H2O <=> 4-hydroxybenzoate + hydroquinone 3.1.1
–
sulfite + 3 NADH + 3 H+ <=> Sulfide + 3 NAD+ + 3 H2O not assigned
 –
glyoxylate + L-serine <=> Hydroxypyruvate + glycine 2.6.1.15 glutamine---pyruvate transaminase
2.6.1.35 glycine---oxaloacetate transaminase
2.6.1.4 glycine transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.45 serine---glyoxylate transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.60 aromatic-amino-acid---glyoxylate transaminase
–
–
–
–
–
–
–
2,4,6-trinitrotoluene + 2 NADH + 2 H+ <=> N-hydroxy-2-methyl-3,5-dinitroaniline + 2 NAD+ + H2O 1
–
H+ + 4-toluenesulfonate + O2 + NADH <=> 4-(hydroxymethyl)benzenesulfonate + NAD+ + H2O 1.14.13
1.14.99
–
–
H+ + Phthalate + O2 + NADH <=> Phthalate_3,4-cis-dihydrodiol + NAD+ 1.14.12
–
H2O + sedoheptulose_1,7-diphosphate <=> sedoheptulose_7-phosphate + phosphate 3.1.3.11 fructose-bisphosphatase
3.1.3.37 sedoheptulose-bisphosphatase
–
–
Benzo[a]pyrene-11,12-epoxide + H2O <=> Benzo[a]pyrene-trans-11,12-dihydrodiol 3.3.2
–
(S)-3-hydroxybutyryl-CoA + NAD+ <=> acetoacetyl-CoA + NADH + H+ 1.1.1.178 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
1.1.1.36 acetoacetyl-CoA reductase
–
–
–
4-amino-2,6-dinitrotoluene + 3 NADH + 3 H+ <=> 2,4-Diamino-6-nitrotoluene + 3 NAD+ + 2 H2O 1.7.1
–
3,5-Dibromo-4-hydroxybenzamide + H2O <=> 3,5-dibromo-4-hydroxybenzoic_acid + NH3 3.5.1
–
D-glyceraldehyde_3-phosphate + NAD+ + H2O <=> 3-phospho-D-glycerate + NADH + H+ 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)
1.2.1.90 glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]
–
–
–
–
–
–
4-hydroxyphenylacetate + O2 + NADPH + H+ <=> homogentisate + H2O + NADP+ 1.14.13.18 4-hydroxyphenylacetate 1-monooxygenase
–
pyruvate + 2-aminoethylphosphonate <=> L-alanine + phosphonoacetaldehyde 2.6.1.18 beta-alanine---pyruvate transaminase
2.6.1.37 2-aminoethylphosphonate---pyruvate transaminase
–
–
benzo(a)pyrene-9,10-dihydrodiol + NAD+ <=> 9,10-dihydroxy-benzo(a)pyrene + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
–
Hydroxymethylbilane <=> uroporphyrinogen_III + H2O 4.2.1.75 uroporphyrinogen-III synthase
–
3,5-dibromo-4-hydroxybenzonitrile + 2 NADPH + 2 H+ + O2 <=> 2,6-dibromo-p-hydroquinone + cyanide + 2 NADP+ + H2O 1.14.13.50 pentachlorophenol monooxygenase
–
4-Hydroxyisophthalate + O2 + NADH + H+ <=> 3,4-dihydroxybenzoate + H2O + NAD+ + CO2 1.14.13
–
ATP + beta-D-glucose <=> ADP + beta-D-glucose_6-phosphate 2.7.1.1 hexokinase
2.7.1.2 glucokinase
–
–
ATP + coenzyme_gamma-F420-2 + L-glutamate <=> ADP + phosphate + coenzyme_alpha-F420-3 6.3.2.32 coenzyme gamma-F420-2:alpha-L-glutamate ligase
–
2,6-dibromophenol <=> 2,6-dibromo-p-hydroquinone not assigned
 –
4-methyl-3-oxoadipate_enol-lactone + H2O <=> 4-methyl-3-oxoadipate + H+ 3.1.1
3.1.1.24 3-oxoadipate enol-lactonase
–
–
O2 + D-glucose <=> D-glucono-1,5-lactone + H2O2 1.1.3.29 N-acylhexosamine oxidase
1.1.3.4 glucose oxidase
1.1.3.5 hexose oxidase
–
–
–
terephthalate + O2 + NADH + H+ <=> (1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+ 1.14.12.15 terephthalate 1,2-dioxygenase
–
Styrene-cis-2,3-dihydrodiol + NAD+ <=> 3-vinylcatechol + NADH + H+ 1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
–
H+ + sulfite + AMP + GSSG <=> adenosine_5''-phosphosulfate + glutathione 1.8.4.10 adenylyl-sulfate reductase (thioredoxin)
1.8.4.9 adenylyl-sulfate reductase (glutathione)
1.8.99.2 adenylyl-sulfate reductase
–
–
–
formylmethanofuran + H2O <=> methanofuran + formate 1.2.7.12 formylmethanofuran dehydrogenase
–
coenzyme_B + coenzyme_M + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> CoM-S-S-CoB + H2 + oxidized_ferredoxin 1.8.98.5 H2:CoB-CoM heterodisulfide,ferredoxin reductase
–
H2O + L-Rhamno-1,4-lactone <=> L-Rhamnonate + H+ 3.1.1.65 L-rhamnono-1,4-lactonase
–
4-hydroxybenzoate + NADPH + O2 + H+ <=> 3,4-dihydroxybenzoate + NADP+ + H2O 1.14.13.2 4-hydroxybenzoate 3-monooxygenase
1.14.13.33 4-hydroxybenzoate 3-monooxygenase [NAD(P)H]
–
–
2-hydroxy-3-methylbenzaldehyde + NAD+ + H2O <=> 3-methylsalicylate + NADH + H+ 1.2.1
–
maleylpyruvate <=> 3-fumarylpyruvate 5.2.1.2 maleylacetoacetate isomerase
5.2.1.4 maleylpyruvate isomerase
–
–
formate + NADP+ <=> CO2 + NADPH 1.17.1.10 formate dehydrogenase (NADP+)
1.17.1.9 formate dehydrogenase
–
–
CoA + Furoic_acid + ATP <=> 2-Furoyl-CoA + diphosphate + AMP 6.2.1.31 2-furoate---CoA ligase
–
D-threo-aldose + NAD+ <=> L-fuconolactone + NADH + H+ 1.1.1.107 pyridoxal 4-dehydrogenase
1.1.1.116 D-arabinose 1-dehydrogenase (NAD+)
1.1.1.122 D-threo-aldose 1-dehydrogenase
–
–
–
H+ + 3-hydroxy-2-methylpyridine-4,5-dicarboxylate <=> CO2 + 3-Hydroxy-2-methylpyridine-5-carboxylate 4.1.1.51 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase
–
O2 + reduced_acceptor + 3-hydroxybenzoate <=> H2O + acceptor + 2,3-Dihydroxybenzoate 1.14.99.23 3-hydroxybenzoate 2-monooxygenase
–
ethylbenzene + O2 + NADH + H+ <=> cis-1,2-dihydro-3-ethylcatechol + NAD+ 1.14.12
–
N2O + 2 ferricytochrome_c + H2O <=> 2 NO + 2 ferricytochrome_c + 2 H+ 1.7.2.5 nitric oxide reductase (cytochrome c)
–
6-phosphogluconate + NAD+ <=> D-ribulose_5-phosphate + CO2 + NADH 1.1.1.343 phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating)
1.1.1.351 phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
–
–
–
4-(methylamino)-1-(pyridin-3-yl)butan-1-one + H2O <=> 4-oxo-4-(pyridin-3-yl)butanoate + methylamine not assigned
 –
H+ + 4-hydroxybenzoate <=> CO2 + phenol 4.1.1.103 gamma-resorcylate decarboxylase
4.1.1.61 4-hydroxybenzoate decarboxylase
–
–
(R)-2-benzylsuccinate <=> Toluene + fumarate 4.1.99.11 benzylsuccinate synthase
–
sedoheptulose_7-phosphate + D-glyceraldehyde_3-phosphate <=> D-ribose_5-phosphate + D-xylulose_5-phosphate 2.2.1.1 transketolase
2.2.1.3 formaldehyde transketolase
–
–
Hydroxyquinol + O2 <=> 3-hydroxy-cis,cis-muconate + H+ 1.13.11.37 hydroxyquinol 1,2-dioxygenase
–
NH3 + 2 H2O + 6 ferricytochrome_c <=> nitrite + 6 ferricytochrome_c + 7 H+ 1.7.2.2 nitrite reductase (cytochrome; ammonia-forming)
–
scyllo-inosose <=> 2D-2,3,5/4,6-pentahydroxycyclohexanone 5.3.99.11 2-keto-myo-inositol isomerase
–
D-gluconate + FAD + H+ <=> 2-dehydro-D-gluconate + FADH2 1.1.99.3 gluconate 2-dehydrogenase (acceptor)
–
p-xylene + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 4-methylbenzyl_alcohol + oxidized_ferredoxin + H2O 1.14.15.26 toluene methyl-monooxygenase
–
4,4''-Dihydroxy-alpha-methylstilbene + O2 <=> 4-hydroxybenzaldehyde + 4''-Hydroxyacetophenone 1.3
–
D-glucono-1,5-lactone + H2O <=> H+ + D-gluconate 3.1.1.17 gluconolactonase
3.1.1.35 dihydrocoumarin hydrolase
–
–
4-Hydroxyphthalate <=> 3-hydroxybenzoate + CO2 4.1.1.55 4,5-dihydroxyphthalate decarboxylase
–
2-dehydro-3-deoxy-D-gluconate <=> D-glyceraldehyde + pyruvate 4.1.2.14 2-dehydro-3-deoxy-phosphogluconate aldolase
4.1.2.20 2-dehydro-3-deoxyglucarate aldolase
4.1.2.51 2-dehydro-3-deoxy-D-gluconate aldolase
4.1.2.55 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
–
–
–
–
(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate <=> cis-4-carboxymethylenebut-2-en-4-olide + Cl- + H+ not assigned
 –
ATP + 15,173-seco-F430-173-acid <=> ADP + phosphate + coenzyme_F430 6.4.1.9 coenzyme F430 synthetase
–
1-naphthoic_acid + O2 + NADH + H+ <=> cis-1,2-Dihydroxy-1,2-dihydro-8-carboxynaphthalene + NAD+ 1.14.12
–
ATP + D-allose <=> ADP + D-Allose_6-phosphate 2.7.1.55 allose kinase
–
vinyl_chloride + O2 + NADH + H+ <=> 2-chloroethylene_oxide + H2O + NAD+ 1.14.13.69 alkene monooxygenase
–
N-(6-aminohexanoyl)n-6-aminohexanoate + H2O <=> N-(6-aminohexanoyl)-6-aminohexanoate 3.5.1.117 6-aminohexanoate-oligomer endohydrolase
3.5.1.46 6-aminohexanoate-oligomer exohydrolase
–
–
1,1,1-trichloroethane <=> 1,1-Dichloroethane + Hydrochloric_acid 1.97.1
–
5,6,7,8-tetrahydromethanopterin + formylmethanofuran + H+ <=> 5-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran 2.3.1.101 formylmethanofuran---tetrahydromethanopterin N-formyltransferase
–
2,4-dinitrotoluene + 3 NADPH + 3 H+ <=> 2-Amino-4-nitrotoluene + 3 NADP+ + 2 H2O 1.7.1
–
methane + hydroquinone + O2 <=> methanol + 1,4-benzoquinone + H2O 1.14.18.3 methane monooxygenase (particulate)
–
acetyl-CoA + Acrylate <=> acetate + acryloyl-CoA 2.8.3.1 propionate CoA-transferase
2.8.3.12 glutaconate CoA-transferase
–
–
anthranilate + O2 + NADH + H+ <=> catechol + CO2 + NH3 + NAD+ 1.14.12.1 anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
–
1,4,5,6-Tetrahydro-6-oxonicotinate + H2O <=> (S)-2-formylglutarate + NH3 3.5.2.18 enamidase
–
succinate_semialdehyde + NAD+ + H2O <=> NADH + succinate + H+ 1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.21 glycolaldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.79 succinate-semialdehyde dehydrogenase (NADP+)
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
–
–
–
–
–
–
–
–
2-Chloro-2-hydroxyethyl-CoM <=> acetyl-CoA not assigned
 –
propionaldehyde + pyruvate <=> 4-hydroxy-2-oxohexanoate 4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolase
4.1.3.39 4-hydroxy-2-oxovalerate aldolase
4.1.3.43 4-hydroxy-2-oxohexanoate aldolase
–
–
–
pyruvate + D-glyceraldehyde <=> 2-dehydro-3-deoxy-D-galactonate 4.1.2.14 2-dehydro-3-deoxy-phosphogluconate aldolase
4.1.2.21 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
4.1.2.23 3-deoxy-D-manno-octulosonate aldolase
4.1.2.51 2-dehydro-3-deoxy-D-gluconate aldolase
4.1.2.55 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
–
–
–
–
–
(Z)-hex-1-ene-1,2,6-tricarboxylate + H2O <=> (-)-threo-iso(homo)3citrate 4.2.1.114 methanogen homoaconitase
–
O2 + 3,4-dihydroxybenzoate <=> H+ + 3-carboxy-cis,cis-muconate 1.13.11.3 protocatechuate 3,4-dioxygenase
–
4-Chlorocatechol + O2 <=> H+ + 3-chloro-cis,cis-muconate 1.13.11.1 catechol 1,2-dioxygenase
1.13.11.M6
–
–
4-toluenesulfonate + NADH + O2 <=> sulfite + 4-methylcatechol + NAD+ 1.14.12
1.14.12.14 2-aminobenzenesulfonate 2,3-dioxygenase
–
–
2-ketocyclohexane-1-carboxyl-CoA + H2O <=> H+ + pimeloyl-CoA 3.1.2
3.7.1
–
–
D-arabino-hex-3-ulose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.27 6-phospho-3-hexuloisomerase
–
H+ + Allantoate + H2O <=> (S)-ureidoglycine + NH3 + CO2 3.5.3.9 allantoate deiminase
–
ethylene + O2 + NADH + H+ <=> Epoxyethane + H2O + NAD+ 1.14.13.25 methane monooxygenase (soluble)
1.14.13.69 alkene monooxygenase
–
–
Theobromine + O2 + NADPH + H+ <=> 3-Methylxanthine + formaldehyde + NADP+ 1.13.12
1.14.13.128 7-methylxanthine demethylase
–
–
5,10-methylenetetrahydromethanopterin + NADP+ <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH 1.5.1
–
L-threo-3-methylaspartate <=> L-glutamate 5.4.99.1 methylaspartate mutase
–
3-carboxy-2-hydroxymuconate_semialdehyde + H+ <=> 2-hydroxymuconate-6-semialdehyde + CO2 4.1.1
–
3,4-dihydroxybenzoate + NADH + O2 <=> Hydroxyquinol + NAD+ + CO2 1.13.11
1.14.13.64 4-hydroxybenzoate 1-hydroxylase
–
–
(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 <=> (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H+ 1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase
–
gamma-pentachlorocyclohexene <=> H+ + 1,3,4,6-tetrachloro-1,4-cyclohexadiene + Cl- 4.5.1
4.5.1.B1
–
–
methylamine + coenzyme_M <=> NH3 + methyl-CoM 2.1.1.247 [methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.248 methylamine---corrinoid protein Co-methyltransferase
–
–
1,3,7-trimethyluric_acid + O2 + NADH + H+ <=> 1,3,7-trimethyl-5-hydroxyisourate + NAD+ + H2O 1.14.13.212 1,3,7-trimethyluric acid 5-monooxygenase
–
4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate + H2O <=> 4-oxalomesaconate + methanol not assigned
 –
4-hydroxymuconic_acid_semialdehyde + NAD+ + H2O <=> maleylacetate + NADH + H+ 1.2.1.61 4-hydroxymuconic-semialdehyde dehydrogenase
–
2,4,6-Trihydroxytoluene <=> p-Cresol not assigned
 –
H+ + Naphthalene + O2 + NADH <=> (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
1.14.12.23 nitroarene dioxygenase
1.14.12.24 2,4-dinitrotoluene dioxygenase
–
–
–
–
benzaldehyde + H2O + NADP+ <=> benzoate + NADPH + H+ 1.1.1.195 cinnamyl-alcohol dehydrogenase
1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.7 benzaldehyde dehydrogenase (NADP+)
1.2.1.79 succinate-semialdehyde dehydrogenase (NADP+)
–
–
–
–
–
–
–
–
–
–
benzoate + NADH + H+ + O2 <=> 2-hydro-1,2-dihydroxybenzoate + NAD+ 1.14.12.10 benzoate 1,2-dioxygenase
–
pyridoxamine + O2 + H2O <=> pyridoxal + NH3 + H2O2 1.4.3
1.4.3.5 pyridoxal 5'-phosphate synthase
–
–
catechol + O2 <=> 2-hydroxymuconate-6-semialdehyde + H+ 1.13.11.1 catechol 1,2-dioxygenase
1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase
1.13.11.2 catechol 2,3-dioxygenase
1.13.11.36 chloridazon-catechol dioxygenase
1.13.11.37 hydroxyquinol 1,2-dioxygenase
1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase
–
–
–
–
–
–
(S)-1-phenylethanol + O2 + NADH + H+ <=> acetophenone + NAD+ + 2 H2O 1.14.12.12 naphthalene 1,2-dioxygenase
–
4-(methylamino)-1-(pyridin-3-yl)butan-1-one + O2 + H2O <=> 4-oxo-4-(pyridin-3-yl)butanal + methylamine + H2O2 1.4.3.24 pseudooxynicotine oxidase
–
parathion + reduced_flavodoxin + O2 <=> paraoxon + flavin + sulfur + H2O 1.14.14.1 unspecific monooxygenase
–
4-hydroxylamino-2,6-dinitrotoluene + NADH + H+ <=> 4-amino-2,6-dinitrotoluene + NAD+ + H2O 1.7.1
–
benzoate + reduced_flavodoxin + O2 <=> 4-hydroxybenzoate + flavin + H2O 1.14.14.1 unspecific monooxygenase
1.14.14.92 benzoate 4-monooxygenase
–
–
5-carboxymethyl-2-hydroxymuconate_semialdehyde + H2O + NADP+ <=> 5-Carboxymethyl-2-hydroxymuconate + NADPH 1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
1.2.1.60 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
–
–
6-hydroxycyclohex-1-ene-1-carbonyl-CoA <=> cyclohexa-1,5-diene-1-carbonyl-CoA + H2O 4.2.1.100 cyclohexa-1,5-dienecarbonyl-CoA hydratase
–
Trichloroethylene <=> chloral 1.14
–
2,4-Diamino-6-nitrotoluene <=> 2,4-Diamino-6-hydroxylaminotoluene 1.12.99.6 hydrogenase (acceptor)
1.2.7.1 pyruvate synthase
1.2.7.4 anaerobic carbon monoxide dehydrogenase
–
–
–
Benzene + NADH + O2 <=> phenol + NAD+ + H2O 1.14.13.236 toluene 4-monooxygenase
1.14.13.244 phenol 2-monooxygenase (NADH)
1.14.13.25 methane monooxygenase (soluble)
–
–
–
5,5''-Dehydrodivanillate + O2 + NADPH + H+ <=> 2,2'',3-Trihydroxy-3''-methoxy-5,5''-dicarboxybiphenyl + NADP+ + H2O + formaldehyde not assigned
 –
D-fructose_1,6-bisphosphate <=> dihydroxyacetone_phosphate + D-glyceraldehyde_3-phosphate 4.1.2.13 fructose-bisphosphate aldolase
4.1.2.40 tagatose-bisphosphate aldolase
–
–
6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O <=> H+ + 3-hydroxypimeloyl-CoA 3.7.1.21 6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase
–
2-Naphthoyl-CoA + H2O <=> 2-naphthoic_acid + CoA 2.8.3
–
(3R)-hydroxybutyryl-CoA + NADP+ <=> acetoacetyl-CoA + NADPH + H+ 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase
1.1.1.157 3-hydroxybutyryl-CoA dehydrogenase
1.1.1.36 acetoacetyl-CoA reductase
–
–
–
2-Methylbenzoate + O2 + NADH + H+ <=> 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate + NAD+ 1.14.12
–
2,3-Dihydroxy-2''-carboxybiphenyl + O2 <=> 2-Hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate 1.13
–
2''-aminobiphenyl-2,3-diol + O2 <=> H+ + (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate 1.13.11
1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase
–
–
furfural + H2O + O2 <=> Furoic_acid + H2O2 1.2.3.1 aldehyde oxidase
–
(3S)-3-hydroxyadipyl-CoA + NAD+ <=> H+ + 3-oxoadipyl-CoA + NADH 1.1.1.157 3-hydroxybutyryl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
–
–
biphenyl + NADPH + O2 <=> cis-2,3-dihydro-2,3-dihydroxybiphenyl + NADP+ 1.14.12.18 biphenyl 2,3-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
–
–
trans-1,3-dichloropropene + H2O <=> trans-3-Chloro-2-propene-1-ol + Hydrochloric_acid 3.8.1.5 haloalkane dehalogenase
–
NAD+ + cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate <=> CO2 + NADH + 4-methylcatechol 1.3.1.67 cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase
–
H2O + phosphonoacetaldehyde <=> H+ + phosphate + acetaldehyde 3.11.1.1 phosphonoacetaldehyde hydrolase
–
Monobromobisphenol_A <=> bisphenol_A + Hydrobromic_acid 1.97.1
–
2-(4''-Chlorophenyl)-3,3-dichloropropenoate <=> 4-chlorophenylacetate not assigned
 –
2,5-dichloro-p-quinol + O2 + FADH2 <=> 5-chloro-2-hydroxy-[1,4]-benzoquinone + Cl- + H2O + FAD + H+ 1.14.14
–
homogentisate + O2 <=> 2,5-dihydroxybenzaldehyde + CO2 + H2O 1.13.12
–
beta-methylmalyl-CoA <=> 2-methylfumaryl-CoA + H2O 4.2.1.148 2-methylfumaryl-CoA hydratase
4.2.1.153 3-methylfumaryl-CoA hydratase
–
–
S-(5-Hydroxy-2-furoyl)-CoA + H2O <=> 2-oxoglutaryl-CoA + H+ 3.1.1
–
vinyl_chloride + 2 H+ <=> ethylene + Hydrochloric_acid 1.97.1
–
5-(hydroxymethyl)-2-furaldehyde + O2 + H2O <=> furan-2,5-dicarboxylate + H2O2 + H+ 1.1.3.47 5-(hydroxymethyl)furfural oxidase
–
6-phosphogluconate <=> 2-keto-3-deoxy_phosphogluconate + H2O 4.2.1.12 phosphogluconate dehydratase
–
glycolaldehyde + H2O + NAD+ <=> glycolate + NADH + H+ 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.21 glycolaldehyde dehydrogenase
1.2.1.22 lactaldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.69 fluoroacetaldehyde dehydrogenase
1.2.1.8 betaine-aldehyde dehydrogenase
–
–
–
–
–
–
–
–
–
GTP + coenzyme_F420-0 + L-glutamate <=> GDP + phosphate + coenzyme_F420-1 6.3.2.31 coenzyme F420-0:L-glutamate ligase
–
3,6-dichlorocatechol + O2 <=> 2,5-dichloro-cis,cis-muconate + H+ 1.13.11
1.13.11.M6
–
–
2-hydroxyethyl-CoM <=> coenzyme_M + Epoxyethane 4.4.1.23 2-hydroxypropyl-CoM lyase
–
Sulfide + glutathione + a_quinone <=> S-sulfanylglutathione + a_quinol 1.8.5.8 eukaryotic sulfide quinone oxidoreductase
–
(S)-malate + CoA + ATP <=> phosphate + (3S)-3-carboxy-3-hydroxypropanoyl-CoA + ADP 6.2.1.5 succinate---CoA ligase (ADP-forming)
6.2.1.9 malate---CoA ligase
–
–
pyruvate + L-aspartate_4-semialdehyde <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+ 4.3.3.7 4-hydroxy-tetrahydrodipicolinate synthase
–
Nicotine + CO2 + H+ <=> 1-Methylpyrrolinium + nicotinate not assigned
 –
cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+ <=> 2,3-Dihydroxybiphenyl + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
1.3.1.56 cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
–
–
N6-acetyl-N6-hydroxy-L-lysine + citrate + ATP <=> N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + AMP + diphosphate + H+ 6.3.2.38 N2-citryl-N6-acetyl-N6-hydroxylysine synthase
–
hydrazine + 4 ferricytochrome_c <=> N2 + 4 ferricytochrome_c 1.7.2.8 hydrazine dehydrogenase
–
L-2,4-diaminobutanoate + 2-oxoglutarate <=> L-aspartate_4-semialdehyde + L-glutamate 2.6.1.46 diaminobutyrate---pyruvate transaminase
2.6.1.76 diaminobutyrate---2-oxoglutarate transaminase
4.1.1.86 diaminobutyrate decarboxylase
–
–
–
(3S)-3-carboxy-3-hydroxypropanoyl-CoA + H2O <=> (S)-malate + CoA + H+ 3.1.2.30 (3S)-malyl-CoA thioesterase
–
cis-1,2-Dihydroxy-3,6-dichlorocyclohexa-3,5-diene + NAD+ <=> 3,6-dichlorocatechol + NADH + H+ 1.3.1.119 chlorobenzene dihydrodiol dehydrogenase
–
1-phenanthrol + CH3-R <=> 1-Methoxyphenanthrene + R 2.1.1
–
fumarate + coenzyme_M + coenzyme_B <=> succinate + CoM-S-S-CoB 1.3.4.1 fumarate reductase (CoM/CoB)
–
H2O + N-succinyl-LL-2,6-diaminoheptanedioate <=> LL-2,6-Diaminoheptanedioate + succinate 3.5.1.18 succinyl-diaminopimelate desuccinylase
–
6-Oxo-2-hydroxy-7-(4''-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7E-trienoate + H2O <=> 2-(4''-Chlorophenyl)-3,3-dichloropropenoate + (2Z)-3-chloro-2-hydroxypenta-2,4-dienoic_acid 3.7.1
–
H+ + 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> CO2 + 2-(5-oxo-4,5-dihydrofuran-2-yl)acetic_acid 4.1.1.44 4-carboxymuconolactone decarboxylase
–
3-chlorocatechol + O2 <=> 3-chloro-2-hydroxymuconic_semialdehyde + H2O 1.13.11.2 catechol 2,3-dioxygenase
1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase
–
–
2-hydroxy-1,4-benzoquinone <=> 1,4-benzoquinone + H2O 1.1
–
Hydroxyquinol + O2 <=> H+ + maleylacetate 1.13.11.1 catechol 1,2-dioxygenase
1.13.11.37 hydroxyquinol 1,2-dioxygenase
–
–
ethylbenzene <=> Styrene + 2 H+ 1.14.12.12 naphthalene 1,2-dioxygenase
–
trans-9(S),10(S)-Dihydrodiolphenanthrene <=> 9-Phenanthrol + H2O not assigned
 –
2-Hydroxy-5-methyl-cis,cis-muconic_semialdehyde + NAD+ + H2O <=> (2E,4Z)-2-hydroxy-5-methylhexa-2,4-diendioate + NADH + H+ 1.2.1.85 2-hydroxymuconate-6-semialdehyde dehydrogenase
–
fluorene + O2 + 2 H+ <=> 3,4-Dihydroxyfluorene not assigned
 –
ATP + adipate + CoA <=> AMP + diphosphate + adipyl-CoA 6.2.1
6.2.1.14 6-carboxyhexanoate---CoA ligase
6.2.1.23 dicarboxylate---CoA ligase
–
–
–
2,6-dichloroquinone + NADH + H+ <=> 2,6-dichlorohydroquinone + NAD+ not assigned
 –
2,5-Dichloro-carboxymethylenebut-2-en-4-olide + H2O <=> 2,5-dichloromaleylacetate + H+ 3.1.1.45 carboxymethylenebutenolidase
–
L-rhamnose <=> L-Rhamnofuranose not assigned
 –
isocitrate + NADP+ <=> oxalosuccinate + NADPH + H+ 1.1.1.42 isocitrate dehydrogenase (NADP+)
–
Thiobenzamide_S-oxide + NADPH + H+ + O2 <=> Thiobenzamide_S,S-dioxide + NADP+ + H2O 1.14.13
–
cadaverine + 2-oxoglutarate <=> 5-Aminopentanal + L-glutamate 2.6.1
2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.29 diamine transaminase
2.6.1.82 putrescine---2-oxoglutarate transaminase
–
–
–
–
(S)-Mandelate <=> (R)-mandelate 5.1.2.2 mandelate racemase
–
4-Hydroxyisophthalate + O2 + NADPH + H+ <=> 3,4-dihydroxybenzoate + CO2 + NADP+ + H2O 1.14.13
–
Benzoylsuccinyl-CoA + CoA <=> benzoyl-CoA + succinyl-CoA 2.3.1
2.3.1.M17
–
–
6-hydroxyhexanoate + NAD+ <=> H+ + 6-oxohexanoate + NADH 1.1.1.258 6-hydroxyhexanoate dehydrogenase
–
vanillic_acid + tetrahydrofolate <=> 3,4-dihydroxybenzoate + 5-methyltetrahydrofolate 2.1.1.341 vanillate/3-O-methylgallate O-demethylase
–
carboxybiuret + H2O <=> 1,3-dicarboxyurea + NH3 3.5.1.131 1-carboxybiuret hydrolase
–
cis-1,2-dichloroethene + 2 H+ <=> vinyl_chloride + Hydrochloric_acid 1.97.1
–
D-gluconate <=> H2O + 2-dehydro-3-deoxy-D-gluconate 4.2.1.140 gluconate/galactonate dehydratase
4.2.1.39 gluconate dehydratase
4.2.1.82 xylonate dehydratase
4.2.1.9 dihydroxy-acid dehydratase
–
–
–
–
2-Hydroxy-6-oxo-6-(4''-chlorophenyl)-hexa-2,4-dienoate + H2O <=> 4-Chlorobenzoate + 2-hydroxy-2,4-pentadienoate 3.7.1.8 2,6-dioxo-6-phenylhexa-3-enoate hydrolase
–
GTP + coenzyme_F420-1 + L-glutamate <=> GDP + phosphate + coenzyme_gamma-F420-2 6.3.2.34 coenzyme F420-1:gamma-L-glutamate ligase
–
2-oxohept-3-enedioate <=> 2-hydroxyhepta-2,4-dienedioate 5.3.2.6 2-hydroxymuconate tautomerase
5.3.3
–
–
D-ribulose_5-phosphate + ATP <=> H+ + D-ribulose_1,5-bisphosphate + ADP 2.7.1.19 phosphoribulokinase
–
cyclohexanecarboxyl-CoA + acceptor <=> cyclohex-1-ene-1-carbonyl-CoA + reduced_acceptor 1.3
–
S-adenosyl-L-methionine + 7-methylxanthine <=> H+ + Theobromine + S-adenosyl-L-homocysteine 2.1.1.159 theobromine synthase
2.1.1.160 caffeine synthase
–
–
3-methylbenzyl_alcohol + NAD+ <=> H+ + 3-methylbenzaldehyde + NADH 1.1.1.21 aldose reductase
1.1.1.90 aryl-alcohol dehydrogenase
–
–
cis,cis-tetrachloromuconic_acid <=> 2,3,5-Trichlorodienelactone + Hydrochloric_acid 5.5.1.7 chloromuconate cycloisomerase
–
3-methylcatechol + O2 <=> 2-hydroxy-6-oxohepta-2,4-dienoate + H+ 1.13.11
1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase
1.13.11.2 catechol 2,3-dioxygenase
1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase
1.13.11.56 1,2-dihydroxynaphthalene dioxygenase
–
–
–
–
–
2-naphthoic_acid + FADH2 + O2 <=> 1-hydroxy-2-naphthoate + FAD + H2O not assigned
 –
hexachlorocyclohexane <=> gamma-pentachlorocyclohexene + Cl- + H+ 4.5.1
4.5.1.B1
–
–
1,2,4-trichlorobenzene <=> 1,4-dichlorobenzene not assigned
 –
paraxanthine + NADH + O2 + H+ <=> 7-methylxanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase
–
–
glycolate + NADP+ <=> glyoxylate + NADPH + H+ 1.1.1.21 aldose reductase
1.1.1.215 gluconate 2-dehydrogenase
1.1.1.237 hydroxyphenylpyruvate reductase
1.1.1.26 glyoxylate reductase
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.81 hydroxypyruvate reductase
1.1.1.92 oxaloglycolate reductase (decarboxylating)
–
–
–
–
–
–
–
5-Fluoromuconolactone + H2O <=> maleylacetate + F- 3.1.1.45 carboxymethylenebutenolidase
–
CoA + acetate + ATP <=> phosphate + acetyl-CoA + ADP 6.2.1.1 acetate---CoA ligase
6.2.1.13 acetate---CoA ligase (ADP-forming)
6.2.1.B11
–
–
–
myo-inositol + NAD+ <=> scyllo-inosose + NADH + H+ 1.1.1.114 apiose 1-reductase
1.1.1.18 inositol 2-dehydrogenase
–
–
nitrite + H2O + NAD+ <=> H+ + nitrate + NADH 1.17.3.2 xanthine oxidase
1.7.1.1 nitrate reductase (NADH)
1.7.1.2 nitrate reductase [NAD(P)H]
1.7.1.3 nitrate reductase (NADPH)
–
–
–
–
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ 1.17.1.8 4-hydroxy-tetrahydrodipicolinate reductase
–
4-pyridoxate + acceptor <=> 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + reduced_acceptor 1.1.99.42 4-pyridoxic acid dehydrogenase
–
4-hydroxybenzoate + NADH + O2 + H+ <=> 3,4-dihydroxybenzoate + NAD+ + H2O 1.14.13.2 4-hydroxybenzoate 3-monooxygenase
1.14.13.33 4-hydroxybenzoate 3-monooxygenase [NAD(P)H]
1.14.99.15 4-methoxybenzoate monooxygenase (O-demethylating)
–
–
–
Phenanthrene-4,5-dicarboxylate <=> Phenanthrene-4-carboxylate + CO2 4.1.1
–
succinyl-CoA + mesaconate <=> 2-methylfumaryl-CoA + succinate 2.8.3.26 succinyl-CoA:mesaconate CoA transferase
–
epsilon-Caprolactam + H2O <=> 6-aminohexanoate 3.5.2
–
4-Chlorophenoxyacetate + 2-oxoglutarate + O2 <=> 4-Chlorophenol + glyoxylate + succinate + CO2 1.14.11
–
2-naphthaldehyde + NAD+ + H2O <=> 2-naphthoic_acid + NADH 1.2.1
1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.65 salicylaldehyde dehydrogenase
–
–
–
–
–
2-dehydro-3-deoxy-L-fuconate + NAD+ <=> 2,4-didehydro-3-deoxy-L-rhamnonate + NADH + H+ 1.1.1
–
Naphthyl-2-methylene-succinyl-CoA + H2O <=> Naphthyl-2-hydroxymethyl-succinyl_CoA 4.2.1
–
(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate <=> 3-chloro-cis,cis-muconate + H+ 5.5.1.1 muconate cycloisomerase
5.5.1.7 chloromuconate cycloisomerase
–
–
parathion + 3 reduced_acceptor <=> Aminoparathion + 3 acceptor + 2 H2O not assigned
 –
4-oxalomesaconate <=> 4-carboxy-2-hydroxy-cis,cis-muconate 5.3.2.8 4-oxalomesaconate tautomerase
–
2,3-Bis(4-hydroxyphenyl)-1,2-propanediol <=> 2,4'-dihydroxyacetophenone + 4-hydroxybenzoate 1.13
–
pyruvate + ATP <=> H+ + phosphoenolpyruvate + ADP 2.7.1.40 pyruvate kinase
–
6-oxohexanoate + H2O + NADP+ <=> H+ + adipate + NADPH 1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.63 6-oxohexanoate dehydrogenase
–
–
2-Hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate <=> 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + CO2 4.1.1
–
L-lysine + (3R)-3-methyl-D-ornithine + ATP <=> (2R,3R)-3-Methylornithinyl-N6-lysine + products_of_ATP_breakdown 6.3.2
–
cuminaldehyde + NAD+ + H2O <=> H+ + cumic_acid + NADH 1.2.1.29 aryl-aldehyde dehydrogenase
–
Urate + O2 + H2O <=> 5-hydroxyisourate + H2O2 1.7.3.3 factor-independent urate hydroxylase
–
vanillic_acid + O2 + NADH + H+ <=> 3,4-dihydroxybenzoate + formaldehyde + NAD+ + H2O 1.14.13.82 vanillate monooxygenase
–
2,3,5-trichloromaleylacetate + NADH <=> 2,4-dichloro-3-oxohexanedioic_acid + NAD+ + Cl- 1.3.1.32 maleylacetate reductase
–
benzyl_alcohol + NAD+ <=> benzaldehyde + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.245 cyclohexanol dehydrogenase
1.1.1.265 3-methylbutanal reductase
1.1.1.307 D-xylose reductase
1.1.1.347 geraniol dehydrogenase (NAD+)
1.1.1.6 glycerol dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.73 octanol dehydrogenase
1.1.1.90 aryl-alcohol dehydrogenase
1.14.14.51 (S)-limonene 6-monooxygenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
–
–
–
–
–
–
–
–
–
–
–
–
–
(Z)-phenylacetaldoxime <=> phenylacetonitrile + H2O 1.14.14.44 phenylacetaldehyde oxime monooxygenase
4.99.1.5 aliphatic aldoxime dehydratase
4.99.1.7 phenylacetaldoxime dehydratase
–
–
–
2-Chloro-5-methyl-cis-dienelactone + H2O <=> 2-chloro-5-methylmaleylacetate + H+ 3.1.1
3.1.1.45 carboxymethylenebutenolidase
–
–
phenylacetate + reduced_flavodoxin + O2 <=> 2-hydroxyphenylacetate + flavin + H2O 1.14.14.54 phenylacetate 2-hydroxylase
–
6-hydroxy-N-methylmyosmine + H2O <=> 1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one 1.5.3.5 (S)-6-hydroxynicotine oxidase
1.5.3.6 (R)-6-hydroxynicotine oxidase
–
–
Biuret + H2O <=> allophanate + NH3 3.5.1.84 biuret amidohydrolase
–
2-Hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O <=> Phthalate + 2-hydroxy-2,4-pentadienoate 3.7.1
–
1-naphthaldehyde + NAD+ + H2O <=> 1-naphthoic_acid + NADH 1.2.1
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.39 phenylacetaldehyde dehydrogenase
1.2.1.65 salicylaldehyde dehydrogenase
–
–
–
–
(S)-malate + NAD+ <=> pyruvate + CO2 + NADH 1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.39 malate dehydrogenase (decarboxylating)
1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
1.1.1.85 3-isopropylmalate dehydrogenase
1.3.1.7 meso-tartrate dehydrogenase
–
–
–
–
–
9,10-Dihydroxyanthracene <=> anthraquinone + 2 H+ not assigned
 –
L-glutamate + oxidized_ferredoxin <=> 2-oxoglutarate + L-glutamine + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.4.7.1 glutamate synthase (ferredoxin)
–
benzoylformate + H+ <=> CO2 + benzaldehyde 4.1.1.1 pyruvate decarboxylase
4.1.1.7 benzoylformate decarboxylase
4.1.1.72 branched-chain-2-oxoacid decarboxylase
4.1.1.74 indolepyruvate decarboxylase
–
–
–
–
7-methylxanthine + NADH + O2 + H+ <=> xanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
–
1-Hydroxypyrene-7,8-oxide <=> 1,8-dihydroxypyrene not assigned
 –
Dimethylamine + coenzyme_M <=> methyl-CoM + methylamine 2.1.1.247 [methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.249 dimethylamine---corrinoid protein Co-methyltransferase
–
–
NAD+ + H2O + L-glutamate <=> NADH + 2-oxoglutarate + NH3 + H+ 1.4.1.14 glutamate synthase (NADH)
1.4.1.2 glutamate dehydrogenase
1.4.1.3 glutamate dehydrogenase [NAD(P)+]
1.4.1.4 glutamate dehydrogenase (NADP+)
1.4.1.5 L-amino-acid dehydrogenase
–
–
–
–
–
6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+ <=> H+ + 6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH 1.1.1.368 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
–
sedoheptulose_7-phosphate + D-glyceraldehyde_3-phosphate <=> beta-D-fructose_6-phosphate + D-erythrose_4-phosphate 2.2.1.1 transketolase
2.2.1.2 transaldolase
–
–
5,10-methylenetetrahydromethanopterin + glycine + H2O <=> 5,6,7,8-tetrahydromethanopterin + L-serine 2.1.2
2.1.2.1 glycine hydroxymethyltransferase
–
–
4-(3-Hydroxy-2-naphthyl)-2-oxobut-3-enoic_acid + 2 H2O <=> 3-hydroxy-2-naphthoate + pyruvate not assigned
 –
L-lactaldehyde + NAD+ + H2O <=> L-lactate + NADH + H+ 1.2.1.22 lactaldehyde dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
–
–
Pyrene-1,2-oxide <=> 1-hydroxypyrene not assigned
 –
9alpha-hydroxy-1,4-androstadiene_3,17-dione <=> 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 0.0.0.0
–
nitrate + a_quinol <=> nitrite + a_quinone + H2O 1.7.5.1 nitrate reductase (quinone)
–
2,4-didehydro-3-deoxy-L-rhamnonate + H2O <=> pyruvate + L-lactate + H+ 3.7.1.26 2,4-didehydro-3-deoxy-L-rhamnonate hydrolase
–
Pyrene-4,5-dione <=> Phenanthrene-4,5-dicarboxylate 1.6
–
5,10-methylenetetrahydromethanopterin + coenzyme_F420 + H+ <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced_coenzyme_F420 1.5.98.1 methylenetetrahydromethanopterin dehydrogenase
–
3-methylsalicylate + NADH + O2 <=> 3-methylcatechol + CO2 + NAD+ + H2O 1.14.13.1 salicylate 1-monooxygenase
–
1-Methylxanthine + NADPH + O2 + H+ <=> xanthine + NADP+ + formaldehyde + H2O 1.14.13.178 methylxanthine N1-demethylase
–
adipyl-CoA + FAD <=> 2,3-dehydroadipyl-CoA + FADH2 1.3.99
–
phosphate + acetyl-CoA <=> acetyl_phosphate + CoA 2.3.1.19 phosphate butyryltransferase
2.3.1.222 phosphate propanoyltransferase
2.3.1.8 phosphate acetyltransferase
–
–
–
O2 + 3,4-Dihydroxyphenylacetate <=> H+ + 5-carboxymethyl-2-hydroxymuconate_semialdehyde 1.13.11.15 3,4-dihydroxyphenylacetate 2,3-dioxygenase
–
Aminoparathion + H2O <=> H+ + diethyl_thiophosphate + 4-Aminophenol 3.1.8.1 aryldialkylphosphatase
–
(RS)-nicotine + acceptor + H2O <=> 6-hydroxy-L-nicotine + reduced_acceptor 1.5.99.4 nicotine dehydrogenase
–
3-Phenylpropionic_acid <=> 3-(3-Hydroxyphenyl)propanoic_acid not assigned
 –
trimethylamine + H2O + flavin <=> Dimethylamine + formaldehyde + reduced_flavodoxin 1.5.8.2 trimethylamine dehydrogenase
–
NH3 + H2O + NAD+ <=> nitrite + NADH + H+ 1.7.1.10 hydroxylamine reductase (NADH)
1.7.1.15 nitrite reductase (NADH)
1.7.1.4 nitrite reductase [NAD(P)H]
–
–
–
4-hydroxyphenylacetate + O2 + NADH + H+ <=> homogentisate + H2O + NAD+ 1.14.13.18 4-hydroxyphenylacetate 1-monooxygenase
–
Bis(4-hydroxyphenyl)methane <=> Bis(4-hydroxyphenyl)methanol 1.14
–
Maleate <=> fumarate 5.2.1.1 maleate isomerase
–
succinyl-CoA + 3-oxoadipate <=> succinate + 3-oxoadipyl-CoA 2.8.3.6 3-oxoadipate CoA-transferase
–
3-Hydroxybenzyl_alcohol + NADP+ <=> 3-Hydroxybenzaldehyde + NADPH + H+ 1.1.1.184 carbonyl reductase (NADPH)
1.1.1.91 aryl-alcohol dehydrogenase (NADP+)
1.1.1.97 3-hydroxybenzyl-alcohol dehydrogenase
–
–
–
D-erythrose_4-phosphate + D-xylulose_5-phosphate <=> beta-D-fructose_6-phosphate + D-glyceraldehyde_3-phosphate 2.2.1.1 transketolase
2.2.1.3 formaldehyde transketolase
–
–
6-amino-hexanoate_cyclic_dimer + H2O <=> N-(6-aminohexanoyl)-6-aminohexanoate 3.5.1.117 6-aminohexanoate-oligomer endohydrolase
3.5.2.12 6-aminohexanoate-cyclic-dimer hydrolase
–
–
2-hydroxymethylglutarate <=> 2-Methyleneglutarate + H2O not assigned
 –
thiosulfate + cyanide <=> H+ + sulfite + thiocyanate 2.8.1.1 thiosulfate sulfurtransferase
2.8.1.2 3-mercaptopyruvate sulfurtransferase
–
–
hydroxylamine + H2O + 4 ferricytochrome_c <=> nitrite + 4 ferricytochrome_c + 5 H+ 1.7.2.2 nitrite reductase (cytochrome; ammonia-forming)
1.7.2.6 hydroxylamine dehydrogenase
1.7.99.1 hydroxylamine reductase
–
–
–
cyclohexanone + NADPH + H+ + O2 <=> epsilon-caprolactone + NADP+ + H2O 1.14.13.16 cyclopentanone monooxygenase
1.14.13.22 cyclohexanone monooxygenase
1.14.13.92 phenylacetone monooxygenase
–
–
–
(3S)-citramalyl-CoA <=> 3-methylfumaryl-CoA + H2O 4.2.1.148 2-methylfumaryl-CoA hydratase
4.2.1.153 3-methylfumaryl-CoA hydratase
–
–
3,4,6-Trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+ <=> 3,4,6-trichlorocatechol + NADH + H+ 1.3.1.119 chlorobenzene dihydrodiol dehydrogenase
–
2,5-Dichloro-p-benzoquinone + NADH + H+ <=> 2,5-dichlorohydroquinone + NAD+ not assigned
 –
bisphenol_A + NADH + H+ + O2 <=> 1,2-Bis(4-hydroxyphenyl)-2-propanol + NAD+ + H2O 1.14
–
tetrahydrofolate + ATP + formate <=> 10-formyltetrahydrofolate + ADP + phosphate 6.3.4.3 formate---tetrahydrofolate ligase
–
4-formylbenzenesulfonate + NAD+ + H2O <=> H+ + 4-Sulfobenzoate + NADH 1.2.1.62 4-formylbenzenesulfonate dehydrogenase
–
parathion + H2O <=> H+ + diethyl_thiophosphate + 4-nitrophenol 3.1.8.1 aryldialkylphosphatase
–
methylamine + H2O + amicyanin <=> formaldehyde + NH3 + reduced_amicyanin + H+ 1.4.9.1 methylamine dehydrogenase (amicyanin)
–
trans-3-Chloro-2-propene-1-ol + NAD+ <=> trans-3-Chloroallyl_aldehyde + NADH + H+ 1.1.1.1 alcohol dehydrogenase
–
2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O 4.2.1.11 phosphopyruvate hydratase
–
2 1-Indanone + O2 + 2 NADPH + 2 H+ <=> 2 3-hydroxy-1-indanone + 2 NADP+ 1.14.12
–
5-deoxy-D-glucuronate <=> 5-dehydro-2-deoxy-D-gluconate 5.3.1.30 5-deoxy-glucuronate isomerase
–
N-cyclohexylformamide + H2O <=> Cyclohexylamine + formate 3.5.1
–
5-methoxygallic_acid + tetrahydrofolate <=> gallic_acid + 5-methyltetrahydrofolate 2.1.1.341 vanillate/3-O-methylgallate O-demethylase
–
H2O + Allantoate <=> (S)-ureidoglycolate + Urea 3.5.3.4 allantoicase
–
4-Hydroxymethylsalicylaldehyde + NAD+ + H2O <=> 4-Hydroxymethylsalicylate + NADH + H+ 1.2.1
–
AMP + sulfite + FAD <=> adenosine_5'-phosphosulfate + FADH2 1.8.99.2 adenylyl-sulfate reductase
–
3-oxo-5,6-dehydrosuberyl-CoA_semialdehyde + NADP+ + H2O <=> 3-oxo-5,6-dehydrosuberyl-CoA + NADPH + H+ 1.2.1.91 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase
–
(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H2O <=> 2-hydroxy-2,4-pentadienoate + fumarate 3.7.1.14 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase
–
benzo[a]pyrene + O2 + NADH + H+ <=> benzo(a)pyrene-9,10-dihydrodiol + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase
–
Sulfide + protein_disulfide + 2 acceptor + 3 H2O <=> sulfite + protein-dithiol + 2 reduced_acceptor + 2 H+ 1.8.99.5 dissimilatory sulfite reductase
–
4-oxalocrotonate + H2O <=> 4-hydroxy-2-oxopentanoate + CO2 4.1.1
–
Pyrene-4,5-oxide + H2O <=> trans-4,5-Dihydroxy-4,5-dihydropyrene 3.3.2
–
NAD+ + trans-1,2-cyclohexanediol <=> H+ + NADH + 2-Hydroxycyclohexan-1-one 1.1.1.174 cyclohexane-1,2-diol dehydrogenase
–
5-dehydro-2-deoxy-D-gluconate + ATP <=> H+ + 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP 2.7.1.92 5-dehydro-2-deoxygluconokinase
–
anthranilate + CoA + ATP <=> 2-aminobenzoyl-CoA + AMP + diphosphate 6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.25 benzoate---CoA ligase
6.2.1.32 anthranilate---CoA ligase
–
–
–
benzoylpropionyl-CoA + CoA <=> benzoyl-CoA + acetyl-CoA 2.3.1
2.3.1.16 acetyl-CoA C-acyltransferase
–
–
(S)-malate + NAD+ <=> oxaloacetate + NADH + H+ 1.1.1.28 D-lactate dehydrogenase
1.1.1.299 malate dehydrogenase [NAD(P)+]
1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.81 hydroxypyruvate reductase
1.1.1.82 malate dehydrogenase (NADP+)
1.1.1.85 3-isopropylmalate dehydrogenase
1.1.1.95 phosphoglycerate dehydrogenase
1.1.1.96 diiodophenylpyruvate reductase
–
–
–
–
–
–
–
–
–
–
–
Sulfanilic_acid + 4-Aminobenzoic_acid <=> 4-Carboxy-4''-sulfoazobenzene + 4 H+ 1.7.1
–
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one <=> 2,6-Dihydroxy-N-methylmyosmine + H2O not assigned
 –
trichloroacetate + 2 H2O <=> oxalate + 3 Hydrochloric_acid 3.8.1
–
bisphenol_A + NADH + H+ + O2 <=> 2,2-Bis(4-hydroxyphenyl)-1-propanol + NAD+ + H2O 1.14.13
–
m-cresol + O2 + NADH + H+ <=> 3-Hydroxybenzyl_alcohol + NAD+ + H2O 1.14.13
–
(2R)-O-phospho-3-sulfolactate <=> phosphoenolpyruvate + sulfite + H+ 4.4.1.19 phosphosulfolactate synthase
–
4-toluenesulfonate + O2 <=> p-Cresol + sulfate 1.14.13
–
N-cyclohexylformamide <=> H2O + cyclohexyl_isocyanide 4.2.1.103 cyclohexyl-isocyanide hydratase
–
ethanol + ubiquinone <=> acetaldehyde + ubiquinol 1.1.5.5 alcohol dehydrogenase (quinone)
–
(R)-2-hydroxybutane-1,2,4-tricarboxylate <=> (Z)-but-1-ene-1,2,4-tricarboxylate + H2O 4.2.1
4.2.1.114 methanogen homoaconitase
4.2.1.36 homoaconitate hydratase
–
–
–
H+ + 2-nitrobenzoate + NADPH <=> o-Hydroxylaminobenzoate + NADP+ + H2O 1.7.1
–
O2 + NADH + 4-Sulfobenzoate <=> sulfite + NAD+ + 3,4-dihydroxybenzoate 1.14.12.8 4-sulfobenzoate 3,4-dioxygenase
–
5-methyltetrahydrofolate + NAD+ <=> 5,10-methylenetetrahydrofolate + H+ + NADH 1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]
–
5-chloro-2-hydroxymuconic-6-semialdehyde + H+ <=> 2-hydroxymuconate-6-semialdehyde + Cl- 1.97.1
–
2-Hydroxy-6-oxo-6-(2-hydroxyphenoxy)-hexa-2,4-dienoate + H2O <=> 2-hydroxy-2,4-hexadienedioate + catechol + H+ 3.7.1
–
2,2',3-trihydroxybiphenyl_ether + O2 <=> 2-Hydroxy-6-oxo-6-(2-hydroxyphenoxy)-hexa-2,4-dienoate + H+ 1.13.11
–
2-oxoglutarate + H2O + acetyl-CoA <=> H+ + (R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA 2.3.3.14 homocitrate synthase
–
H2O + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + succinyl-CoA <=> N-succinyl-L-2-amino-6-oxoheptanedioate + CoA 2.3.1.117 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
–
cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide <=> trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide 5.2.1.10 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase
–
trans-dichloroethylene + 2 H+ <=> vinyl_chloride + Hydrochloric_acid 1.97.1
–
Acrylamide + H2O <=> NH3 + Acrylate 3.5.1.1 asparaginase
3.5.1.4 amidase
3.5.1.49 formamidase
3.5.5.1 nitrilase
–
–
–
–
D-ribose_5-phosphate + ATP <=> H+ + 5-phospho-alpha-D-ribose_1-diphosphate + AMP 2.7.6.1 ribose-phosphate diphosphokinase
–
NADP+ + pyridoxine <=> H+ + NADPH + pyridoxal 1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.65 pyridoxine 4-dehydrogenase
–
–
ATP + D-gluconate <=> H+ + 6-phosphogluconate + ADP 2.7.1.12 gluconokinase
–
2-methylnaphthalene + O2 + NADH + H+ <=> cis-1,2-Dihydroxy-1,2-dihydro-7-methylnaphthalene + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase
–
phenanthrene + NADH + H+ + O2 <=> (+)-cis-3,4-dihydrophenanthrene-3,4-diol + NAD+ 1.13.11
–
S-adenosyl-L-methionine + Theobromine <=> H+ + Caffeine + S-adenosyl-L-homocysteine 2.1.1.160 caffeine synthase
–
glutaconyl-CoA + H+ <=> CO2 + crotonyl-CoA 1.3.8.6 glutaryl-CoA dehydrogenase (ETF)
6.4.1.4 methylcrotonoyl-CoA carboxylase
7.2.4.5 glutaconyl-CoA decarboxylase
–
–
–
H+ + Trimethylamine_N-oxide <=> Dimethylamine + formaldehyde 4.1.2.32 trimethylamine-oxide aldolase
–
trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide + Hydrochloric_acid <=> 2,5-dichloro-cis,cis-muconate 5.5.1.7 chloromuconate cycloisomerase
–
Trichloroethylene <=> 2,2,3-trichlorooxirane 1.14
–
H+ + 3,4-dihydroxyphthalate <=> CO2 + 3,4-dihydroxybenzoate 4.1.1.69 3,4-dihydroxyphthalate decarboxylase
–
allophanate + H2O + H+ <=> NH3 + CO2 3.5.1.54 allophanate hydrolase
–
nicotinate + H2O + NADP+ <=> 6-Hydroxynicotinate + NADPH + H+ 1.17.1.5 nicotinate dehydrogenase
–
L-lysine + O2 + NADPH <=> N6-hydroxy-L-lysine + NADP+ + H2O 1.14.13.59 L-lysine N6-monooxygenase (NADPH)
–
4-hydroxyphenylacetate + NADH + O2 <=> 3,4-Dihydroxyphenylacetate + NAD+ + H2O 1.14.12.9 4-chlorophenylacetate 3,4-dioxygenase
1.14.14.9 4-hydroxyphenylacetate 3-monooxygenase
–
–
Caffeine + NADH + H+ + O2 <=> theophylline + NAD+ + formaldehyde + H2O 1.13.12
–
2 2,3,6-Trihydroxypyridine + 2 O2 <=> nicotine_blue + 2 H2O2 not assigned
 –
2,2,3-trichlorooxirane <=> glyoxylate not assigned
 –
3-hydroxypimeloyl-CoA + NAD+ <=> H+ + NADH + 3-oxopimeloyl-CoA 1.1.1.259 3-hydroxypimeloyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
–
–
5-chloro-1,2,4-trihydroxybenzene <=> 2-hydroxy-1,4-benzoquinone + Cl- + H+ 4.5.1
–
ATP + Ni-sirohydrochlorin_a,c-diamide + reduced_acceptor + H2O <=> ADP + phosphate + 15,173-seco-F430-173-acid + acceptor 6.3.3.7 Ni-sirohydrochlorin a,c-diamide reductive cyclase
–
ATP + beta-D-fructose_6-phosphate <=> H+ + ADP + D-fructose_1,6-bisphosphate 2.7.1.105 6-phosphofructo-2-kinase
2.7.1.11 6-phosphofructokinase
–
–
4-Aminophenol + H2O <=> 1,4-benzoquinone + NH3 1.4
–
salicylate + O2 + NADH + H+ <=> 2,5-Dihydroxybenzoate + NAD+ + H2O 1.14.13.172 salicylate 5-hydroxylase
–
isocitrate + NADP+ <=> 2-oxoglutarate + CO2 + NADPH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.41 isocitrate dehydrogenase (NAD+)
1.1.1.42 isocitrate dehydrogenase (NADP+)
–
–
–
4''-chloro-2,3-dihydroxybiphenyl + O2 <=> 2-hydroxy-6-oxo-6-(4''-chlorophenyl)-hexa-2,4-dienoate + H2O 1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase
–
homoisocitrate <=> (Z)-but-1-ene-1,2,4-tricarboxylate + H2O 4.2.1.114 methanogen homoaconitase
4.2.1.36 homoaconitate hydratase
–
–
2-naphthaldehyde <=> 4-Formylsalicylic_acid not assigned
 –
3-hydroxybenzoate + O2 + NADH + H+ <=> 2,5-Dihydroxybenzoate + H2O + NAD+ 1.14.13.24 3-hydroxybenzoate 6-monooxygenase
–
trihomocitrate <=> (Z)-hex-1-ene-1,2,6-tricarboxylate + H2O 4.2.1.114 methanogen homoaconitase
–
fluorene + O2 + 2 H+ <=> 1,2-Dihydroxyfluorene not assigned
 –
acetyl-CoA + H2O + glyoxylate <=> H+ + (S)-malate + CoA 2.3.3.9 malate synthase
4.1.3.1 isocitrate lyase
–
–
2-oxepin-2(3H)-ylideneacetyl-CoA + H2O <=> 3-oxo-5,6-dehydrosuberyl-CoA_semialdehyde 3.3.2.12 oxepin-CoA hydrolase
–
Atrazine + H2O <=> H+ + 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + Cl- 3.8.1.8 atrazine chlorohydrolase
–
Theobromine + NADH + O2 + H+ <=> 7-methylxanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase
–
–
4-chlorobiphenyl + O2 + NADH + H+ <=> cis-2,3-Dihydro-2,3-dihydroxy-4''-chlorobiphenyl + NAD+ 1.14.12.18 biphenyl 2,3-dioxygenase
–
(S)-2-hydroxyglutarate + a_quinone <=> 2-oxoglutarate + a_quinol 1.1.5.13 (S)-2-hydroxyglutarate dehydrogenase
–
H+ + Toluene + O2 + NADH <=> o-Cresol + H2O + NAD+ 1.14.13.243 toluene 2-monooxygenase
–
O2 + 3,4-dihydroxybenzoate <=> H+ + 4-carboxy-2-hydroxy-cis,cis-muconate_6-semialdehyde 1.13.11.8 protocatechuate 4,5-dioxygenase
–
ATP + 4-Fluorobenzoate + CoA <=> AMP + diphosphate + 4-fluorobenzoyl-CoA 6.2.1.25 benzoate---CoA ligase
6.2.1.27 4-hydroxybenzoate---CoA ligase
6.2.1.32 anthranilate---CoA ligase
6.2.1.33 4-chlorobenzoate---CoA ligase
–
–
–
–
cyclohex-1-ene-1-carbonyl-CoA + flavin <=> cyclohexa-1,5-diene-1-carbonyl-CoA + reduced_flavodoxin 1.3.8.10 cyclohex-1-ene-1-carbonyl-CoA dehydrogenase
–
H+ + dibenzofuran + NADH + O2 <=> 2,2',3-Trihydroxybiphenyl + NAD+ 1.14.12
1.14.12.22 carbazole 1,9a-dioxygenase
–
–
2-methylnaphthalene + fumarate <=> 2-Naphtylmethylsuccinic_acid 4.1.99
–
1-hydroxypyrene + O2 <=> 1-Hydroxypyrene-6,7-oxide + H2O 1.14
–
Caffeine + ubiquinone + H2O <=> 1,3,7-trimethyluric_acid + ubiquinol 1.17.5.2 caffeine dehydrogenase
–
phenylacetaldehyde + H2O + NAD+ <=> phenylacetate + NADH + H+ 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.39 phenylacetaldehyde dehydrogenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.8 betaine-aldehyde dehydrogenase
–
–
–
–
–
acetyl-CoA + H2O + oxaloacetate <=> citrate + CoA + H+ 2.3.3.1 citrate (Si)-synthase
2.3.3.14 homocitrate synthase
2.3.3.16 citrate synthase (unknown stereospecificity)
2.3.3.3 citrate (Re)-synthase
–
–
–
–
2-Aminophenol + O2 <=> 2-aminomuconate_6-semialdehyde 1.13.11.74 2-aminophenol 1,6-dioxygenase
–
2-hydroxyphenylacetate + NADH + O2 <=> homogentisate + NAD+ + H2O 1.14.13
1.14.13.63 3-hydroxyphenylacetate 6-hydroxylase
–
–
Naphthyl-2-methyl-succinyl-CoA <=> Naphthyl-2-methylene-succinyl-CoA + 2 H+ 1.3.99
–
dehydroepiandrosterone + NAD+ <=> 5-androstene-3,17-dione + NADH + H+ 1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase
–
–
ethylene_glycol + NAD+ <=> glycolaldehyde + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.14 L-iditol 2-dehydrogenase
1.1.1.6 glycerol dehydrogenase
1.1.1.77 lactaldehyde reductase
1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+)
–
–
–
–
–
2,4-Dichlorophenol + O2 + NADPH + H+ <=> 3,5-dichlorocatechol + H2O + NADP+ 1.14.13.20 2,4-dichlorophenol 6-monooxygenase
–
phenylacetyl-CoA + O2 + NADPH + H+ <=> 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP+ + H2O 1.14.13.149 phenylacetyl-CoA 1,2-epoxidase
–
6-phospho-5-dehydro-2-deoxy-D-gluconate <=> malonate_semialdehyde + dihydroxyacetone_phosphate 4.1.2.29 5-dehydro-2-deoxyphosphogluconate aldolase
–
D-glyceraldehyde_3-phosphate <=> dihydroxyacetone_phosphate 5.3.1.1 triose-phosphate isomerase
–
pyruvate + phosphate + ATP <=> H+ + phosphoenolpyruvate + AMP + diphosphate 2.7.9.1 pyruvate, phosphate dikinase
–
6-hydroxy-D-nicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2 1.5.3.6 (R)-6-hydroxynicotine oxidase
–
4-carboxy-4-hydroxy-2-oxoadipate <=> 4-oxalomesaconate + H2O 4.2.1.83 4-oxalomesaconate hydratase
–
1,3,4,6-tetrachloro-1,4-cyclohexadiene <=> H+ + Cl- + 1,2,4-trichlorobenzene not assigned
 –
beta-D-glucose + ADP <=> beta-D-glucose_6-phosphate + AMP 2.7.1.147 ADP-specific glucose/glucosamine kinase
–
4,5-Dihydroxybenzo[a]pyrene + O2 <=> 4,5-Chrysenedicarboxylate 1.13.11
–
2,6-dichlorohydroquinone + O2 + H2O <=> H+ + 2-chloromaleylacetate + Cl- 1.13.11
1.13.11.66 hydroquinone 1,2-dioxygenase
–
–
N6-hydroxy-L-lysine + acetyl-CoA <=> N6-acetyl-N6-hydroxy-L-lysine + CoA 2.3.1.102 N6-hydroxylysine N-acetyltransferase
–
4-hydroxybenzaldehyde + NAD+ + H2O <=> 4-hydroxybenzoate + NADH + H+ 1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.29 aryl-aldehyde dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.64 4-hydroxybenzaldehyde dehydrogenase (NAD+)
1.2.1.65 salicylaldehyde dehydrogenase
1.2.1.67 vanillin dehydrogenase
1.2.1.96 4-hydroxybenzaldehyde dehydrogenase (NADP+)
–
–
–
–
–
–
–
2-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate <=> catechol 1.3.1
–
succinate + a_quinone <=> fumarate + a_quinol 1.3.5.1 succinate dehydrogenase
1.3.5.4 fumarate reductase (quinol)
–
–
aniline + O2 <=> catechol + NH3 1.14
–
2-Hydroxycyclohexan-1-one + NAD+ <=> 1,2-Cyclohexanedione + NADH + H+ 1.1.1.174 cyclohexane-1,2-diol dehydrogenase
–
2-chloromaleylacetate + NADH <=> maleylacetate + Cl- + NAD+ 1.3.1.32 maleylacetate reductase
–
fluorobenzene + NADH + O2 + H+ <=> 4-Fluorocyclohexadiene-cis,cis-1,2-diol + NAD+ 1.14.12
–
(S)-malate + a_quinone <=> oxaloacetate + a_quinol 1.1.5.4 malate dehydrogenase (quinone)
–
(furan-2,5-diyl)dimethanol + NAD+ <=> 5-(hydroxymethyl)-2-furaldehyde + NADH + H+ 1.1.1
1.1.1.1 alcohol dehydrogenase
1.1.1.307 D-xylose reductase
–
–
–
Dimethylamine + H2O + flavin <=> methylamine + formaldehyde + reduced_flavodoxin 1.5.8.1 dimethylamine dehydrogenase
–
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ <=> 4,5-Dihydroxyphthalate + NADH + H+ 1.3.1.64 phthalate 4,5-cis-dihydrodiol dehydrogenase
–
H+ + anthranilate + O2 + NADPH <=> NH3 + NADP+ + 2,3-Dihydroxybenzoate 1.14.13.35 anthranilate 3-monooxygenase (deaminating)
–
butyryl-CoA + NADP+ <=> crotonyl-CoA + NADPH + H+ 1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
1.3.1.44 trans-2-enoyl-CoA reductase (NAD+)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)
1.3.1.85 crotonyl-CoA carboxylase/reductase
1.3.1.86 crotonyl-CoA reductase
1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)
–
–
–
–
–
–
–
–
phenanthrene-9,10-oxide + H2O <=> trans-9(S),10(S)-Dihydrodiolphenanthrene 3.3.2
–
Cinnamic_acid + NADH + O2 + H+ <=> trans-3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]-acrylic_acid + NAD+ 1.14.12.19 3-phenylpropanoate dioxygenase
–
L-aspartate_4-semialdehyde + phosphate + NADP+ <=> L-4-aspartyl_phosphate + NADPH + H+ 1.2.1.11 aspartate-semialdehyde dehydrogenase
–
ATP + propionyl-CoA + HCO3- <=> H+ + (S)-methylmalonyl-CoA + phosphate + ADP 6.4.1.2 acetyl-CoA carboxylase
6.4.1.3 propionyl-CoA carboxylase
–
–
cyclohexanecarboxyl-CoA + flavin <=> cyclohex-1-ene-1-carbonyl-CoA + reduced_flavodoxin 1.3.8.11 cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein)
–
Naphthyl-2-hydroxymethyl-succinyl_CoA <=> Naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ 1.1
–
cis-4-carboxymethylenebut-2-en-4-olide + H2O <=> maleylacetate + H+ 3.1.1.45 carboxymethylenebutenolidase
–
melilotate <=> 3-Phenylpropionic_acid not assigned
 –
2-carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> H+ + 3-carboxy-cis,cis-muconate 5.5.1.2 3-carboxy-cis,cis-muconate cycloisomerase
5.5.1.5 carboxy-cis,cis-muconate cyclase
–
–
gallic_acid + O2 <=> 4-oxalomesaconate + H+ 1.13.11.57 gallate dioxygenase
1.13.11.8 protocatechuate 4,5-dioxygenase
–
–
L-Rhamnonate <=> H2O + 2-dehydro-3-deoxy-L-rhamnonate 4.2.1.90 L-rhamnonate dehydratase
–
2 1-Indanone + O2 + 2 NADH + 2 H+ <=> 2 3-hydroxy-1-indanone + 2 NAD+ 1.14.12
–
testosterone + NAD+ <=> 4-androstene-3,17-dione + NADH + H+ 1.1.1.112 indanol dehydrogenase
1.1.1.210 3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62 17beta-estradiol 17-dehydrogenase
1.1.1.64 testosterone 17beta-dehydrogenase (NADP+)
–
–
–
–
–
–
–
(2S)-methylsuccinyl-CoA + flavin <=> 2-methylfumaryl-CoA + reduced_flavodoxin 1.3.8.12 (2S)-methylsuccinyl-CoA dehydrogenase
–
H+ + L-2,4-diaminobutanoate <=> 1,3-diaminopropane + CO2 4.1.1.17 ornithine decarboxylase
4.1.1.18 lysine decarboxylase
4.1.1.86 diaminobutyrate decarboxylase
–
–
–
thiosulfate + dithioerythritol <=> sulfite + oxidized_dithiothreitol + Sulfide + H+ 2.8.1.5 thiosulfate---dithiol sulfurtransferase
–
4-methylcatechol + O2 <=> 3-methyl-cis,cis-muconate + H+ 1.13.11.1 catechol 1,2-dioxygenase
1.13.11.3 protocatechuate 3,4-dioxygenase
–
–
phenol + O2 + NADPH + H+ <=> catechol + H2O + NADP+ 1.14.13.7 phenol 2-monooxygenase (NADPH)
1.14.14.20 phenol 2-monooxygenase (FADH2)
–
–
(S)-allantoin <=> (R)-allantoin 5.1.99.3 allantoin racemase
–
Bis(4-hydroxyphenyl)methanol <=> 4,4''-Dihydroxybenzophenone 1.1
–
5,6,7,8-Tetrahydro-2-naphthoic_acid <=> cis-2-Carboxycyclohexyl-acetic_acid not assigned
 –
m-cresol + NADPH + H+ + O2 <=> 3-methylcatechol + NADP+ + H2O 1.14.13.7 phenol 2-monooxygenase (NADPH)
–
benzoate + CoA + ATP <=> benzoyl-CoA + diphosphate + AMP 6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.25 benzoate---CoA ligase
6.2.1.32 anthranilate---CoA ligase
6.2.1.33 4-chlorobenzoate---CoA ligase
–
–
–
–
(2R)-O-phospho-3-sulfolactate + H2O <=> (2R)-3-sulfolactate + phosphate 3.1.3.71 2-phosphosulfolactate phosphatase
–
4-Maleylacetoacetate <=> 4-Fumarylacetoacetate 5.2.1.2 maleylacetoacetate isomerase
–
3,4-dihydroxybenzoate + NH3 <=> 4-Aminobenzoic_acid + O2 + 2 H+ 1.14.12
–
2,6-dioxo-6-phenylhexa-3-enoate + H2O <=> benzoate + 2-oxopent-4-enoate 3.7.1.8 2,6-dioxo-6-phenylhexa-3-enoate hydrolase
–
benzo[a]pyrene + O2 + NADH + H+ <=> Benzo[a]pyrene-cis-4,5-dihydrodiol + NAD+ 1.14.12
–
(4S)-(+)-muconolactone <=> H+ + cis,cis-muconate 5.5.1.1 muconate cycloisomerase
–
L-ribulose_5-phosphate <=> L-xylulose_5-phosphate 5.1.3.22 L-ribulose-5-phosphate 3-epimerase
–
(3S)-citramalyl-CoA <=> pyruvate + acetyl-CoA 2.3.1.182 (R)-citramalate synthase
4.1.3.25 (S)-citramalyl-CoA lyase
–
–
2,6-dichlorohydroquinone + H2O <=> 6-chlorohydroxyquinol + Cl- not assigned
 –
7-methylxanthine + NADPH + O2 + H+ <=> xanthine + NADP+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
–
(2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O <=> 2-hydroxy-2,4-pentadienoate + succinate 3.7.1.14 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase
–
3-hydroxy-5-oxohexanoyl-CoA + CoA <=> (S)-3-hydroxybutyryl-CoA + acetyl-CoA 2.3.1
–
4-carboxymethyl-4-methylbut-2-en-1,4-olide <=> 4-Carboxymethyl-3-methylbut-2-en-1,4-olide 5.4.99.14 4-carboxymethyl-4-methylbutenolide mutase
–
Ni-sirohydrochlorin + L-glutamine + ATP + H2O <=> Ni-sirohydrochlorin_a,c-diamide + L-glutamate + ADP + phosphate + H+ 6.3.5.12 Ni-sirohydrochlorin a,c-diamide synthase
–
D-glycerate + ATP <=> H+ + 2-phospho-D-glycerate + ADP 2.7.1.165 glycerate 2-kinase
–
N2O + NAD+ + H2O <=> NO + NADH + H+ 1.7.1.14 nitric oxide reductase [NAD(P)+, nitrous oxide-forming]
1.7.2.5 nitric oxide reductase (cytochrome c)
–
–
H+ + 2,6-Dihydroxypyridine + O2 + NADH <=> H2O + NAD+ + 2,3,6-Trihydroxypyridine 1.14.13.10 2,6-dihydroxypyridine 3-monooxygenase
–
methanol + NAD+ <=> H+ + formaldehyde + NADH 1.1.1.1 alcohol dehydrogenase
1.1.1.202 1,3-propanediol dehydrogenase
1.1.1.244 methanol dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.B4
–
–
–
–
–
D-galactonate <=> H2O + 2-dehydro-3-deoxy-D-galactonate 4.2.1.140 gluconate/galactonate dehydratase
4.2.1.39 gluconate dehydratase
4.2.1.6 galactonate dehydratase
–
–
–
3-Methylxanthine + NADPH + O2 + H+ <=> xanthine + NADP+ + formaldehyde + H2O 1.14.13.179 methylxanthine N3-demethylase
–
H+ + 3-sulfopyruvate <=> 2-sulfoacetaldehyde + CO2 4.1.1.79 sulfopyruvate decarboxylase
4.1.1.82 phosphonopyruvate decarboxylase
–
–
beta-D-fructose_6-phosphate + ADP <=> H+ + D-fructose_1,6-bisphosphate + AMP 2.7.1.146 ADP-specific phosphofructokinase
–
3-hydroxypropionate + ATP + CoA <=> bithionol + AMP + diphosphate 6.2.1.17 propionate---CoA ligase
6.2.1.36 3-hydroxypropionyl-CoA synthase
6.2.1.40 4-hydroxybutyrate---CoA ligase (AMP-forming)
–
–
–
4-fluoro-2-hydro-1,2-dihydroxybenzoate + NAD+ <=> 4-Fluorocatechol + NADH + CO2 + H+ 1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
–
cis-Chlorobenzene_dihydrodiol + NADP+ <=> tetrachlorocatechol + NADPH + H+ 1.3.1
–
3-Hydroxybenzaldehyde + NADP+ + H2O <=> 3-hydroxybenzoate + NADPH + H+ 1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.7 benzaldehyde dehydrogenase (NADP+)
–
–
1-Methoxypyrene-6,7-oxide <=> 1-Hydroxy-6-methoxypyrene not assigned
 –
L-glutamate + NADP+ <=> H+ + L-glutamine + 2-oxoglutarate + NADPH 1.4.1.13 glutamate synthase (NADPH)
1.4.1.B5
–
–
H2O + (R)-mandelamide <=> NH3 + (R)-mandelate 3.5.1.86 mandelamide amidase
–
ethylbenzene + O2 + NADH + H+ <=> (S)-1-phenylethanol + NAD+ + H2O 1.14.12.12 naphthalene 1,2-dioxygenase
–
5-Methyl-5,6,7,8-tetrahydromethanopterin + coenzyme_F420 <=> 5,10-methylenetetrahydromethanopterin + reduced_coenzyme_F420 1.5.98.2 5,10-methylenetetrahydromethanopterin reductase
–
3-hydroxy-5-oxohexanoyl-CoA + acetate <=> 3-Hydroxy-5-oxohexanoate + acetyl-CoA 2.8.3.8 acetate CoA-transferase
–
Toluene + O2 + NADPH + H+ <=> m-cresol + NADP+ + H2O 1.14.13
–
4-Methylbenzoate + O2 + NADPH + H+ <=> cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ 1.14.12
–
ATP + cyclohexanecarboxylate + CoA <=> AMP + diphosphate + cyclohexanecarboxyl-CoA 6.2.1
6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.25 benzoate---CoA ligase
–
–
–
4-amino-2,6-dinitrotoluene + 2 NADH + 2 H+ <=> 4-Amino-2-hydroxylamino-6-nitrotoluene + 2 NAD+ + H2O 1.7.1
–
meso-2,6-diaminoheptanedioate + H+ <=> L-lysine + CO2 4.1.1.20 diaminopimelate decarboxylase
–
Trichloroethylene + NADH + H+ + O2 <=> 2,2,3-trichlorooxirane + NAD+ + H2O 1.14.13
1.14.13.25 methane monooxygenase (soluble)
1.14.13.69 alkene monooxygenase
–
–
–
chloral <=> trichloroacetate 1.1
–
phenylboronic_acid + O2 <=> phenol + Boric_acid 1.14
–
succinyl-CoA + (S)-malate <=> succinate + (3S)-3-carboxy-3-hydroxypropanoyl-CoA 2.8.3.18 succinyl-CoA:acetate CoA-transferase
2.8.3.22 succinyl-CoA---L-malate CoA-transferase
–
–
H2O + 4-chlorobenzoyl-CoA <=> H+ + Cl- + 4-hydroxybenzoyl-CoA 3.8.1.7 4-chlorobenzoyl-CoA dehalogenase
–
Theobromine + O2 + NADH + H+ <=> 3-Methylxanthine + NAD+ + H2O + formaldehyde 1.13.12
1.14.13.128 7-methylxanthine demethylase
–
–
4-carboxy-2-hydroxy-cis,cis-muconate_6-semialdehyde + H2O <=> 4-Methylene-2-oxoglutarate + formate 3.7.1
–
L-fuconate <=> 2-dehydro-3-deoxy-L-fuconate + H2O 4.2.1.68 L-fuconate dehydratase
–
2-Aminobenzenesulfonate + NADH + O2 + H+ <=> 3-sulfocatechol + NH3 + NAD+ 1.14.12.14 2-aminobenzenesulfonate 2,3-dioxygenase
–
epsilon-caprolactone + H2O <=> H+ + 6-hydroxyhexanoate 3.1.1
3.1.1.17 gluconolactonase
3.1.1.83 monoterpene epsilon-lactone hydrolase
–
–
–
1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O + acceptor <=> 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + reduced_acceptor 1.5.99.14 6-hydroxypseudooxynicotine dehydrogenase
–
H+ + 3-(3-hydroxyphenyl)propanoate + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+ 1.14.13.127 3-(3-hydroxyphenyl)propanoate hydroxylase
–
H+ + 4-hydroxyphenylglyoxylate <=> 4-hydroxybenzaldehyde + CO2 4.1.1.7 benzoylformate decarboxylase
–
S-adenosyl-L-methionine + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + L-tyrosine <=> 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + 5''-deoxyadenosine + L-methionine + H+ 2.5.1.147 5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase
–
Ni-sirohydrochlorin + H+ <=> sirohydrochlorin + Ni2+ 4.99.1.11 sirohydrochlorin nickelchelatase
–
2-methylfumaryl-CoA <=> 3-methylfumaryl-CoA 5.4.1.3 2-methylfumaryl-CoA isomerase
–
2 1-Indanone + O2 + 2 NADH + 2 H+ <=> 2 dihydrocoumarin + 2 NAD+ 1.14.12
–
D-arabino-hex-3-ulose_6-phosphate <=> D-ribulose_5-phosphate + formaldehyde 4.1.2.43 3-hexulose-6-phosphate synthase
–
2,4-dinitrotoluene + 3 NADH + 3 H+ <=> 4-amino-2-nitrotoluene + 3 NAD+ + 2 H2O 1.7.1
–
1,8-dihydroxypyrene <=> 1,8-pyrenequinone not assigned
 –
2-Chloro-2-hydroxyethyl-CoM <=> coenzyme_M + 2-chloroethylene_oxide 4.4.1.23 2-hydroxypropyl-CoM lyase
–
4-fluoromuconolactone + H2O <=> maleylacetate + F- 3.1.1.45 carboxymethylenebutenolidase
–
2-carboxybenzaldehyde + NAD+ + H2O <=> Phthalate + NADH + H+ 1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.65 salicylaldehyde dehydrogenase
1.2.1.78 2-formylbenzoate dehydrogenase
–
–
–
2 Atrazine + O2 <=> 2 deisopropylatrazine + 2 acetone 1.14.15
–
O2 + 2,4''-dihydroxyacetophenone <=> H+ + formate + 4-hydroxybenzoate 1.13.11.41 2,4'-dihydroxyacetophenone dioxygenase
–
cis-2,3-Dihydro-2,3-dihydroxy-4''-chlorobiphenyl + NAD+ <=> 2,3-Dihydroxy-4''-chlorobiphenyl + NADH + H+ 1.3.1.56 cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
–
(S)-ureidoglycolate + NADP+ <=> Oxalureate + NADPH + H+ 1.1.1.154 ureidoglycolate dehydrogenase
–
D-gluconate + NADP+ <=> 2-dehydro-D-gluconate + NADPH + H+ 1.1.1.215 gluconate 2-dehydrogenase
1.1.1.346 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)
1.1.1.43 phosphogluconate 2-dehydrogenase
–
–
–
L-lactate + NAD+ <=> pyruvate + NADH + H+ 1.1.1.27 L-lactate dehydrogenase
1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)
–
–
–
–
–
ammeline + H2O <=> ammelide + NH3 3.5.4.45 melamine deaminase
3.8.1.8 atrazine chlorohydrolase
–
–
N-(6-aminohexanoyl)-6-aminohexanoate + H2O <=> 6-aminohexanoate 3.5.1.46 6-aminohexanoate-oligomer exohydrolase
–
NO + azide <=> N2O + N2 1.7.1.14 nitric oxide reductase [NAD(P)+, nitrous oxide-forming]
–
glycolate + NAD+ <=> H+ + NADH + glyoxylate 1.1.1.26 glyoxylate reductase
1.1.1.27 L-lactate dehydrogenase
1.1.1.28 D-lactate dehydrogenase
1.1.1.29 glycerate dehydrogenase
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+)
1.1.1.81 hydroxypyruvate reductase
1.1.1.92 oxaloglycolate reductase (decarboxylating)
1.1.99.14 glycolate dehydrogenase
–
–
–
–
–
–
–
–
–
tetrathionate + 2 e- <=> 2 thiosulfate not assigned
 –
3-[6-(Carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate <=> 1,2-Dihydrophthalic_acid not assigned
 –
2-Hydroxy-5-methyl-cis,cis-muconic_semialdehyde + H2O <=> formate + (2E,4Z)-2-hydroxyhexa-2,4-dienoate 3.7.1.9 2-hydroxymuconate-6-semialdehyde hydrolase
–
3-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate + NAD+ <=> 3-fluorocatechol + NADH + CO2 + H+ 1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
–
2,5-dihydroxypyridine + O2 <=> H+ + N-formylmaleamic_acid 1.13.11.9 2,5-dihydroxypyridine 5,6-dioxygenase
–
3D-3,5/4-trihydroxycyclohexa-1,2-dione + H2O <=> 5-deoxy-D-glucuronate + H+ 3.7.1.22 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (ring-opening)
–
2,3,5-trichlorohydroquinone + Cl- + GSSG <=> tetrachlorohydroquinone + glutathione 1.21.4.5 tetrachlorohydroquinone reductive dehalogenase
–
formaldehyde + D-xylulose_5-phosphate <=> dihydroxyacetone + D-glyceraldehyde_3-phosphate 2.2.1.1 transketolase
2.2.1.3 formaldehyde transketolase
–
–
2-Amino-4-nitrotoluene + 3 NADPH + 3 H+ <=> 2,4-Diaminotoluene + 3 NADP+ + 2 H2O 1.7.1
–
(R)-2-methylmalonyl-CoA <=> (S)-methylmalonyl-CoA 5.1.99.1 methylmalonyl-CoA epimerase
–
Trichloroethylene + 2 H+ <=> trans-dichloroethylene + Hydrochloric_acid 1.21.99.5 tetrachloroethene reductive dehalogenase
–
2-hydroxymuconate-6-semialdehyde + H2O <=> formate + 2-oxopent-4-enoate 3.7.1.9 2-hydroxymuconate-6-semialdehyde hydrolase
–
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + NADH + O2 + H+ <=> 2,5-dihydroxypyridine + succinate_semialdehyde + NAD+ + H2O 1.14.13.163 6-hydroxy-3-succinoylpyridine 3-monooxygenase
–
NH3 + O2 + ubiquinol <=> hydroxylamine + H2O + ubiquinone 1.14.99.39 ammonia monooxygenase
–
5-androstene-3,17-dione <=> 4-androstene-3,17-dione 2.5.1.18 glutathione transferase
5.3.3.1 steroid Delta-isomerase
–
–
adenosine_5''-phosphosulfate + ATP <=> H+ + 3''-phosphoadenylyl-sulfate + ADP 2.7.1.25 adenylyl-sulfate kinase
–
testosterone + NADP+ <=> 4-androstene-3,17-dione + NADPH + H+ 1.1.1.146 11beta-hydroxysteroid dehydrogenase
1.1.1.148 estradiol 17alpha-dehydrogenase
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62 17beta-estradiol 17-dehydrogenase
1.1.1.64 testosterone 17beta-dehydrogenase (NADP+)
–
–
–
–
–
–
–
–
–
–
–
O2 + 1-hydroxy-2-naphthoate <=> H+ + (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 1.13.11.38 1-hydroxy-2-naphthoate 1,2-dioxygenase
–
NADPH + O2 + 4-hydroxybenzoate + H+ <=> NADP+ + CO2 + H2O + hydroquinone 1.14.13.64 4-hydroxybenzoate 1-hydroxylase
–
2-oxoglutarate + N-succinyl-LL-2,6-diaminoheptanedioate <=> L-glutamate + N-succinyl-L-2-amino-6-oxoheptanedioate 2.6.1.17 succinyldiaminopimelate transaminase
–
2-Hydroxy-3-methylbenzalpyruvate + H2O <=> 2-hydroxy-3-methylbenzaldehyde + pyruvate 4.2.1
–
H+ + 3-sulfomuconate <=> 4-sulfomuconolactone 5.5.1
5.5.1.2 3-carboxy-cis,cis-muconate cycloisomerase
–
–
2,2-Bis(4-hydroxyphenyl)-1-propanol <=> 2,2-Bis(4-hydroxyphenyl)-propanoic_acid not assigned
 –
(S)-ureidoglycolate + NAD+ <=> Oxalureate + NADH + H+ 1.1.1.154 ureidoglycolate dehydrogenase
1.1.1.350 ureidoglycolate dehydrogenase (NAD+)
–
–
Delta4-Dafachronic_acid <=> 4-androstene-3,17-dione not assigned
 –
4-methylbenzaldehyde + NADP+ + H2O <=> 4-Methylbenzoate + NADPH + H+ 1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.7 benzaldehyde dehydrogenase (NADP+)
–
–
2-chloro-5-methylmaleylacetate + NADH + H+ <=> 5-methylmaleylacetate + NAD+ + Hydrochloric_acid 1.3.1.32 maleylacetate reductase
–
N-hydroxy-2-methyl-3,5-dinitroaniline + NADH + H+ <=> 2-amino-4,6-dinitrotoluene + NAD+ + H2O 1.7.1
–
4-Fluorocyclohexadiene-cis,cis-1,2-diol + NAD+ <=> 4-Fluorocatechol + NADH + H+ 1.3.1
–
(2R,3S)-dimethylmalate <=> propionate + pyruvate 3.7.1.1 oxaloacetase
4.1.3.1 isocitrate lyase
4.1.3.32 2,3-dimethylmalate lyase
–
–
–
4-methylaminobutanoate + H2O + O2 <=> succinate_semialdehyde + methylamine + H2O2 1.5.3.21 4-methylaminobutanoate oxidase (methylamine-forming)
–
O2 + 2,3-Dihydroxybiphenyl <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H+ 1.13.11.25 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase
–
–
cyclopropanecarboxylic_acid + CoA + ATP <=> cyclopropanecarboxyl-CoA + ADP + phosphate 6.2.1
–
4-hydroxylamino-2,6-dinitrotoluene + 2 NADPH + 2 H+ <=> 2,4-Dihydroxylamino-6-nitrotoluene + 2 NADP+ + H2O 1.7.1
–
O2 + methanol <=> H2O2 + formaldehyde 1.1.3.13 alcohol oxidase
1.1.3.6 cholesterol oxidase
–
–
2-(Acetamidomethylene)succinate + 2 H2O <=> acetate + succinate_semialdehyde + NH3 + CO2 3.5.1.29 2-(acetamidomethylene)succinate hydrolase
3.5.1.66 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase
–
–
ATP + beta-D-fructose_6-phosphate <=> H+ + ADP + D-fructose_1,6-bisphosphate 2.7.1.105 6-phosphofructo-2-kinase
2.7.1.11 6-phosphofructokinase
–
–
D-Fructose_1-phosphate <=> dihydroxyacetone_phosphate + D-glyceraldehyde 4.1.2.13 fructose-bisphosphate aldolase
–
4-carboxy-2-hydroxy-cis,cis-muconate_6-semialdehyde + NADP+ <=> 2-Pyrone-4,6-dicarboxylate + NADPH + H+ 1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
–
cis-3-Chloro-2-propene-1-ol + NAD+ <=> cis-3-Chloroallyl_aldehyde + NADH + H+ 1.1.1.1 alcohol dehydrogenase
–
reduced_flavodoxin + N2 + ATP + H2O <=> flavin + NH3 + H2 + ADP + phosphate + H+ 1.19.6.1 nitrogenase (flavodoxin)
–
4,4''-Dihydroxybenzophenone <=> 4-Hydroxyphenyl-4-hydroxybenzoate 1.14
–
6-phosphogluconate + NAD+ <=> 6-phospho-2-dehydro-D-gluconate + NADH + H+ 1.1.1.43 phosphogluconate 2-dehydrogenase
–
6-aminohexanoate + 2-oxoglutarate <=> 6-oxohexanoate + L-glutamate 2.6.1.116 6-aminohexanoate aminotransferase
2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2 alanine transaminase
2.6.1.48 5-aminovalerate transaminase
–
–
–
–
1-hydroxypyrene <=> pyren-1-yl_sulfate 2.8.2
–
1,2-Dichloroethane + H2O <=> 2-Chloroethanol + Cl- + H+ 3.8.1.5 haloalkane dehalogenase
–
D-arabino-hex-3-ulose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.27 6-phospho-3-hexuloisomerase
–
4-chlorophenylacetate + NADH + O2 <=> 3,4-Dihydroxyphenylacetate + Cl- + NAD+ 1.14.12.9 4-chlorophenylacetate 3,4-dioxygenase
–
4-Fluorocatechol + O2 <=> 3-fluoro-cis,cis-muconate 1.13.11.1 catechol 1,2-dioxygenase
–
chlorobenzene + O2 + NADH + H+ <=> cis-1,2-dihydrobenzene-3-chloro-(R,R)-1,2-diol + NAD+ 1.14.12.26 chlorobenzene dioxygenase
–
4,4'-propane-2,2-diylbis(2,6-dibromophenol) <=> Tribromobisphenol_A + Hydrobromic_acid 1.97.1
–
2-fluoro-cis,cis-muconate + H+ <=> 5-Fluoromuconolactone 5.5.1.7 chloromuconate cycloisomerase
–
2-oxohept-3-enedioate + H2O <=> 2,4-Dihydroxyhept-2-enedioate 4.2.1
–
2,2-Bis(4-hydroxyphenyl)-1-propanol + NADH + H+ + O2 <=> 2,3-Bis(4-hydroxyphenyl)-1,2-propanediol + NAD+ + H2O 1.14
–
1,1-Dichloroethane <=> chloroethane + Hydrochloric_acid 1.97.1
–
2-amino-5-oxocyclohex-1-enecarboxyl-CoA + 2 H2O <=> Cyclohexan-1,4-dione + NH3 + CO2 + CoA not assigned
 –
resorcinol + NADH + O2 + H+ <=> Hydroxyquinol + NAD+ + H2O 1.14.13.220 resorcinol 4-hydroxylase (NADH)
1.14.13.6 orcinol 2-monooxygenase
–
–
3-Phenylpropionic_acid + NADH + O2 + H+ <=> 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ 1.14.12.19 3-phenylpropanoate dioxygenase
–
Anthracene-9,10-dihydrodiol <=> 9,10-Dihydroxyanthracene + 2 H+ 1.1
–
succinate + CoA + ATP <=> succinyl-CoA + ADP + phosphate 6.2.1.13 acetate---CoA ligase (ADP-forming)
6.2.1.4 succinate---CoA ligase (GDP-forming)
6.2.1.5 succinate---CoA ligase (ADP-forming)
–
–
–
2-Furoyl-CoA + acceptor + H2O <=> S-(5-Hydroxy-2-furoyl)-CoA + reduced_acceptor 1.3.99.8 2-furoyl-CoA dehydrogenase
–
4-Ethylphenol + NADPH + H+ + O2 <=> 1-(4''-Hydroxyphenyl)ethanol + NADP+ + H2O 1.14.13
–
2-methylnaphthalene + O2 + NADH + H+ <=> 2-naphthalenemethanol + NAD+ + H2O 1.14.13
–
resorcinol + FADH2 + O2 <=> Hydroxyquinol + FAD + H2O + H+ 1.14.14.27 resorcinol 4-hydroxylase (FADH2)
–
4-oxalocrotonate <=> 2-oxopent-4-enoate + CO2 4.1.1.77 2-oxo-3-hexenedioate decarboxylase
–
2-Hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene)but-2-enoic_acid + H2O <=> 1-Formyl-2-indanone + pyruvate not assigned
 –
O2 + H2O + Cyclohexylamine <=> NH3 + H2O2 + cyclohexanone 1.4.3.12 cyclohexylamine oxidase
–
phenylacetaldehyde + NADP+ + H2O <=> phenylacetate + NADPH + H+ 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.39 phenylacetaldehyde dehydrogenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.8 betaine-aldehyde dehydrogenase
–
–
–
–
Trichloroethylene + O2 + 2 H2O + NADH + H+ <=> 2 formate + 3 Hydrochloric_acid + NAD+ 1.14.12.11 toluene dioxygenase
–
aminohydroquinone + H2O <=> Hydroxyquinol + NH3 not assigned
 –
phosphonoacetaldehyde + NAD+ + H2O <=> Phosphonoacetate + NADH + H+ 1.2.1
1.2.1.3 aldehyde dehydrogenase (NAD+)
–
–
5,6-Dichloro-1,3-cyclohexadiene <=> Benzene + 2 Cl- not assigned
 –
trithionate + H2O + acceptor + 2 H2O <=> reduced_acceptor + 3 sulfite 1.8.99.5 dissimilatory sulfite reductase
–
L-Rhamnofuranose + NAD+ <=> L-Rhamno-1,4-lactone + NADH + H+ 1.1.1.173 L-rhamnose 1-dehydrogenase
1.1.1.378 L-rhamnose 1-dehydrogenase [NAD(P)+]
–
–
beta-D-glucose_6-phosphate + NAD+ <=> 6-phospho-D-glucono-1,5-lactone + NADH + H+ 1.1.1.363 glucose-6-phosphate dehydrogenase [NAD(P)+]
1.1.1.388 glucose-6-phosphate dehydrogenase (NAD+)
–
–
4-Chlorocatechol + O2 <=> 5-chloro-2-hydroxymuconic-6-semialdehyde 1.13.11.2 catechol 2,3-dioxygenase
–
1-hydroxypyrene + S-adenosyl-L-methionine <=> 1-Methoxypyrene + S-adenosyl-L-homocysteine 2.1.1
–
acrylonitrile + H2O <=> Acrylate + NH3 3.5.5.1 nitrilase
3.5.5.5 arylacetonitrilase
3.5.5.7 aliphatic nitrilase
–
–
–
3-methyl-cis,cis-muconate <=> 4-Carboxymethyl-3-methylbut-2-en-1,4-olide 5.5.1.1 muconate cycloisomerase
–
methyl-CoM + coenzyme_B <=> CoM-S-S-CoB + methane 2.8.4.1 coenzyme-B sulfoethylthiotransferase
–
phenanthrene + O2 + NADH + H+ <=> 1-phenanthrol + H2O + NAD+ 1.14.13
–
2-hydroxy-6-oxoocta-2,4-dienoate + H2O <=> 2-hydroxy-2,4-pentadienoate + propionate 3.7.1
–
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ <=> H+ + 3-(2,3-dihydroxyphenyl)propanoate + NADH 1.3.1.87 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase
–
Benzo[a]pyrene-cis-4,5-dihydrodiol <=> 4,5-Dihydroxybenzo[a]pyrene 1.3
–
7-Mercaptoheptanoate + L-threonine + ATP <=> H+ + 7-Mercaptoheptanoylthreonine + ADP + phosphate not assigned
 –
2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ <=> 2,5-dichlorohydroquinone + NADH + H+ 1.3.1
–
5-Hydroxybisphenol_A <=> 4,5-Bisphenol-o-quinone not assigned
 –
2-aminobenzoyl-CoA + O2 + NADH + H+ <=> 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD+ 1.14.13.40 anthraniloyl-CoA monooxygenase
–
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ 1.17.1.8 4-hydroxy-tetrahydrodipicolinate reductase
–
2-aminobenzoyl-CoA + O2 + NADPH + H+ <=> 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NADP+ 1.14.13.40 anthraniloyl-CoA monooxygenase
–
(2R)-ethylmalonyl-CoA <=> (2S)-methylsuccinyl-CoA 5.4.99.63 ethylmalonyl-CoA mutase
–
D-fructose_1,6-bisphosphate + H2O <=> beta-D-fructose_6-phosphate + phosphate 3.1.3.11 fructose-bisphosphatase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.37 sedoheptulose-bisphosphatase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase
–
–
–
–
Styrene + FADH2 + O2 <=> H+ + (S)-styrene_oxide + FAD + H2O 1.14.14.11 styrene monooxygenase
–
o-Hydroxylaminobenzoate + 2 H+ <=> anthranilate + H2O 1.4
–
Pentachlorophenol + O2 + NADPH + H+ <=> tetrafluoro-1,4-benzoquinone + Cl- + NADP+ + H2O 1.14.13.50 pentachlorophenol monooxygenase
–
D-glyceraldehyde_3-phosphate + H2O + oxidized_ferredoxin <=> 3-phospho-D-glycerate + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.6 glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)
–
trihomocitrate <=> (-)-threo-iso(homo)3citrate 4.2.1.114 methanogen homoaconitase
–
4-carboxy-4-hydroxy-2-oxoadipate <=> pyruvate + oxaloacetate 4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase
4.1.3.B3
–
–
Phthalate_3,4-cis-dihydrodiol + NAD+ <=> 3,4-dihydroxyphthalate + NADH + H+ 1.3.1
–
4-androstene-3,17-dione + acceptor <=> 1,4-androstadiene-3,17-dione + reduced_acceptor 1.3.99.4 3-oxosteroid 1-dehydrogenase
–
D-Allose_6-phosphate <=> D-allulose_6-phosphate 5.3.1.6 ribose-5-phosphate isomerase
–
propionaldehyde + CoA + NAD+ <=> propionyl-CoA + NADH + H+ 1.2.1.10 acetaldehyde dehydrogenase (acetylating)
1.2.1.27 methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
1.2.1.57 butanal dehydrogenase
1.2.1.87 propanal dehydrogenase (CoA-propanoylating)
–
–
–
–
pyrene + O2 <=> cis-4,5-Dihydroxy-4,5-dihydropyrene 1.14
–
precorrin-2 + NAD+ <=> H+ + sirohydrochlorin + NADH 1.3.1.76 precorrin-2 dehydrogenase
–
porphobilinogen + H2O <=> Hydroxymethylbilane + NH3 2.5.1.61 hydroxymethylbilane synthase
–
oxamate + Carbamoyl_phosphate <=> phosphate + Oxalureate 2.1.3.5 oxamate carbamoyltransferase
–
coenzyme_B + coenzyme_M + coenzyme_F420 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> CoM-S-S-CoB + reduced_coenzyme_F420 + oxidized_ferredoxin 1.8.98.4 coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
–
5,10-methylenetetrahydrofolate + NADP+ <=> 5,10-methenyltetrahydrofolate + NADPH 1.5.1.15 methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+)
–
–
(R)-2-hydroxybutane-1,2,4-tricarboxylate <=> homoisocitrate 4.2.1.114 methanogen homoaconitase
–
3-hydroxy-2-naphthoate <=> 2,3-dihydroxynaphthalene not assigned
 –
(-)-threo-iso(homo)2citrate + NAD+ <=> 2-oxopimelic_acid + CO2 + NADH 1.1.1
–
NH3 + HCO3- + ATP <=> Carbamoyl_phosphate + ADP + H2O + H+ 2.7.2.2 carbamate kinase
–
nitrite + oxidized_ferredoxin + H2O <=> nitrate + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.7.7.2 ferredoxin---nitrate reductase
–
NAD+ + (+)-cis-3,4-dihydrophenanthrene-3,4-diol <=> H+ + NADH + 3,4-Dihydroxyphenanthrene 1.3.1.49 cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase
–
Benzonitrile + H2O <=> benzoate + NH3 3.5.5.1 nitrilase
3.5.5.5 arylacetonitrilase
3.5.5.7 aliphatic nitrilase
–
–
–
isocitrate + NAD+ <=> 2-oxoglutarate + CO2 + NADH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.41 isocitrate dehydrogenase (NAD+)
1.1.1.42 isocitrate dehydrogenase (NADP+)
1.1.1.87 homoisocitrate dehydrogenase
–
–
–
–
1,2-Bis(4-hydroxyphenyl)-2-propanol <=> 4,4''-(1E)-prop-1-ene-1,2-diyldiphenol + H2O 4.2.1
–
D-allulose_6-phosphate <=> beta-D-fructose_6-phosphate 5.1.3
–
H+ + N-isopropylammelide + H2O <=> cyanuric_acid + propan-2-amine 3.5.4.42 N-isopropylammelide isopropylaminohydrolase
–
pyrene + O2 <=> Pyrene-1,2-oxide + H2O 1.14
–
adenosine_3,5''-bisphosphate + sulfite + thioredoxin_disulfide + H+ <=> 3''-phosphoadenylyl-sulfate + thioredoxin 1.8.4.8 phosphoadenylyl-sulfate reductase (thioredoxin)
–
malonate_semialdehyde + H+ <=> acetaldehyde + CO2 4.1.1
4.2.1.155 (methylthio)acryloyl-CoA hydratase
–
–
2-keto-3-deoxy_phosphogluconate <=> D-glyceraldehyde_3-phosphate + pyruvate 4.1.2.14 2-dehydro-3-deoxy-phosphogluconate aldolase
4.1.2.20 2-dehydro-3-deoxyglucarate aldolase
4.1.2.51 2-dehydro-3-deoxy-D-gluconate aldolase
4.1.2.55 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
–
–
–
–
Benzo[a]pyrene-cis-11,12-dihydrodiol <=> 11,12-Dihydroxybenzo[a]pyrene 1.3
–
phenylacetonitrile + H2O <=> phenylacetate + NH3 3.5.5.1 nitrilase
3.5.5.5 arylacetonitrilase
3.5.5.7 aliphatic nitrilase
4.2.1.84 nitrile hydratase
–
–
–
–
(3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O <=> 2-carboxybenzaldehyde + pyruvate 4.1.2.34 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase
4.1.2.45 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
–
–
2,4-dinitrotoluene + 3 NADPH + 3 H+ <=> 4-amino-2-nitrotoluene + 3 NADP+ + 2 H2O 1.7.1
–
(2R,3R)-3-Methylglutamyl-5-semialdehyde-N6-lysine <=> H+ + pyrrolysine + H2O not assigned
 –
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O <=> 2,6-Dihydroxypyridine + 4-methylaminobutanoate + H+ 3.7.1.19 2,6-dihydroxypseudooxynicotine hydrolase
–
phosphoenolpyruvate + CO2 <=> phosphate + oxaloacetate 4.1.1.31 phosphoenolpyruvate carboxylase
–
ethylbenzene + H2O + acceptor <=> (S)-1-phenylethanol + reduced_acceptor 1.17.99.2 ethylbenzene hydroxylase
–
2,6-dihydroxybenzoate + H+ <=> resorcinol + CO2 4.1.1.103 gamma-resorcylate decarboxylase
–
4-hydroxylamino-2,6-dinitrotoluene + H2O + NADP+ <=> 2,4,6-trinitrotoluene + NADPH + H+ 1
1.7.1
1.7.1.B1
1.7.1.B3
–
–
–
–
L-ectoine + H2O <=> N2-acetyl-L-2,4-diaminobutanoate 3.5.4.44 ectoine hydrolase
4.2.1.108 ectoine synthase
–
–
4-sulfocatechol + O2 <=> H+ + 3-sulfomuconate 1.13.11
1.13.11.3 protocatechuate 3,4-dioxygenase
–
–
3,5-dibromo-4-hydroxybenzonitrile + H2O <=> 3,5-Dibromo-4-hydroxybenzamide 4.2.1.84 nitrile hydratase
–
D-glyceraldehyde_3-phosphate + phosphate + NADP+ <=> 3-phospho-D-glyceroyl_phosphate + NADPH + H+ 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
1.2.1.13 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)
1.2.1.59 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating)
1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)
–
–
–
–
3-fluoro-cis,cis-muconate <=> 4-fluoromuconolactone 5.5.1.1 muconate cycloisomerase
–
3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione + O2 + FMNH2 <=> H+ + 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + FMN 1.14.14.12 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
–
N2O + NADP+ + H2O <=> NO + NADPH + H+ 1.7.1.14 nitric oxide reductase [NAD(P)+, nitrous oxide-forming]
1.7.2.5 nitric oxide reductase (cytochrome c)
–
–
phenol + ATP + H2O <=> Phenyl_phosphate + AMP + phosphate + H+ 2.7.9
–
4-cymene + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> 4-Isopropylbenzyl_alcohol + oxidized_ferredoxin + H2O 1.14.15.25 p-cymene methyl-monooxygenase
–
L-glutamate + NAD+ <=> L-glutamine + 2-oxoglutarate + NADH + H+ 1.4.1.13 glutamate synthase (NADPH)
1.4.1.14 glutamate synthase (NADH)
–
–
2-oxoglutarate + CoA + oxidized_ferredoxin <=> succinyl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.11 2-oxoacid oxidoreductase (ferredoxin)
1.2.7.3 2-oxoglutarate synthase
–
–
cholest-4-en-3-one + 6 [2Fe-2S]-center + 3 O2 <=> (25R)-3-oxocholest-4-en-26-oate + 6 [2Fe-2S]-center + 4 H2O 1.14.15.28 cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]
–
Naphthyl-2-oxomethyl-succinyl-CoA + CoA <=> 2-Naphthoyl-CoA + succinyl-CoA 2.3.1
–
NADP+ + cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate <=> CO2 + NADPH + 4-methylcatechol 1.3.1.67 cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase
–
cyclohexa-1,5-diene-1-carbonyl-CoA <=> cyclohex-1,4-diene-1-carboxyl-CoA not assigned
 –
6-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate <=> 3-fluorocatechol 1.3.1
–
3-phospho-D-glycerate + ATP <=> 3-phospho-D-glyceroyl_phosphate + ADP 2.7.2.10 phosphoglycerate kinase (GTP)
2.7.2.3 phosphoglycerate kinase
–
–
2,2'',3-Trihydroxybiphenyl + O2 <=> 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)hexa-2,4-dienoate 1.13.11
–
1,2-Dihydroxy-8-methylnaphthalene + O2 <=> 2-Hydroxy-8-methylchromene-2-carboxylate 1.13
–
3,4-dihydroxybenzoate + NADPH + O2 <=> Hydroxyquinol + NADP+ + CO2 1.13.11
1.14.13.64 4-hydroxybenzoate 1-hydroxylase
–
–
tetrachloroethene + 2 H+ <=> Trichloroethylene + Hydrochloric_acid 1.21.99.5 tetrachloroethene reductive dehalogenase
–
cis-3-chloroacrylate <=> malonate_semialdehyde + Cl- 3.8.1
5.3.2.1 phenylpyruvate tautomerase
–
–
4-nitrocatechol + O2 + 3 H+ <=> Hydroxyquinol + nitrite + H2O 1.14
–
(S)-3-hydroxybutyryl-CoA <=> H2O + crotonyl-CoA 1.3.8.7 medium-chain acyl-CoA dehydrogenase
4.2.1.116 3-hydroxypropionyl-CoA dehydratase
4.2.1.150 short-chain-enoyl-CoA hydratase
4.2.1.17 enoyl-CoA hydratase
–
–
–
–
Sulfanilic_acid + O2 + 2 H+ <=> 4-sulfocatechol + NH3 1.14.12
–
polyethylene_terephthalate + H2O <=> polyethylene_terephthalate + mono(2-hydroxyethyl)_terephthalate 3.1.1.101 poly(ethylene terephthalate) hydrolase
–
H+ + 4,5-Dihydroxyphthalate <=> CO2 + 3,4-dihydroxybenzoate 4.1.1.55 4,5-dihydroxyphthalate decarboxylase
–
cis-3-Chloroallyl_aldehyde + H2O <=> cis-3-Chloroacrylic_acid + 2 H+ 1.2.1.3 aldehyde dehydrogenase (NAD+)
–
nicotine_blue_leuco_form + NAD+ <=> nicotine_blue + NADH + H+ 1.1.1.328 nicotine blue oxidoreductase
–
Urea <=> H2O + cyanamide 4.2.1.69 cyanamide hydratase
4.2.1.84 nitrile hydratase
–
–
S-sulfanylglutathione + O2 + H2O <=> glutathione + sulfite + H+ 1.13.11.18 persulfide dioxygenase
–
4-hydroxybutanoyl-CoA <=> crotonyl-CoA + H2O 4.2.1.120 4-hydroxybutanoyl-CoA dehydratase
–
3,6,8-Trimethylallantoin + 2 H2O <=> N,N''-Dimethylurea + N-methylurea + glyoxylate not assigned
 –
O2 + homogentisate <=> H+ + 4-Maleylacetoacetate 1.13.11.5 homogentisate 1,2-dioxygenase
–
H+ + L-glutamate <=> CO2 + 4-aminobutanoate 4.1.1.15 glutamate decarboxylase
4.1.1.25 tyrosine decarboxylase
4.1.1.29 sulfinoalanine decarboxylase
–
–
–
2,4-dinitrotoluene + O2 + NADH <=> 4-methyl-5-nitrocatechol + NAD+ + nitrite 1.14.12.24 2,4-dinitrotoluene dioxygenase
–
5-chloro-2-hydroxy-[1,4]-benzoquinone + NADH <=> 5-chloro-1,2,4-trihydroxybenzene + NAD+ 1.6.5.7 2-hydroxy-1,4-benzoquinone reductase
–
(2S)-ethylmalonyl-CoA <=> (2R)-ethylmalonyl-CoA 5.1.99.1 methylmalonyl-CoA epimerase
–
D-glucose + NADP+ <=> D-glucono-1,5-lactone + NADPH + H+ 1.1.1.119 glucose 1-dehydrogenase (NADP+)
1.1.1.179 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming)
1.1.1.359 aldose 1-dehydrogenase [NAD(P)+]
1.1.1.360 glucose/galactose 1-dehydrogenase
1.1.1.424 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
–
–
–
–
–
–
–
methanol + ferricytochrome_b5 <=> formaldehyde + ferricytochrome_b5 + H+ 1.1.2.10 lanthanide-dependent methanol dehydrogenase
1.1.2.7 methanol dehydrogenase (cytochrome c)
1.1.2.e
–
–
–
2-hydroxy-6-oxo-6-(2-hydroxyphenyl)hexa-2,4-dienoate + H2O <=> 2-oxopent-4-enoate + salicylate 3.7.1
3.7.1.8 2,6-dioxo-6-phenylhexa-3-enoate hydrolase
–
–
L-rhamnose + NAD+ <=> L-Rhamno-1,4-lactone + NADH + H+ 1.1.1.173 L-rhamnose 1-dehydrogenase
1.1.1.378 L-rhamnose 1-dehydrogenase [NAD(P)+]
–
–
3-Nitrophenol + 2 NADH + 2 H+ <=> 3-hydroxyaminophenol + 2 NAD+ + H2O 1.7.1
–
cis-1,2-Cyclohexanediol + NAD+ <=> 2-Hydroxycyclohexan-1-one + NADH 1.1.1.174 cyclohexane-1,2-diol dehydrogenase
–
4-Fluorobenzoate + NADH + H+ + O2 <=> 4-fluoro-2-hydro-1,2-dihydroxybenzoate + NAD+ 1.14.12.10 benzoate 1,2-dioxygenase
–
D-glyceraldehyde_3-phosphate + phosphate + NAD+ <=> 3-phospho-D-glyceroyl_phosphate + NADH + H+ 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
1.2.1.13 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)
1.2.1.59 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating)
1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)
–
–
–
–
4-hydroxybenzaldehyde + NADP+ + H2O <=> 4-hydroxybenzoate + NADPH + H+ 1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.67 vanillin dehydrogenase
1.2.1.7 benzaldehyde dehydrogenase (NADP+)
1.2.1.96 4-hydroxybenzaldehyde dehydrogenase (NADP+)
–
–
–
–
–
L-homoserine + ATP <=> H+ + O-phospho-L-homoserine + ADP 2.7.1.39 homoserine kinase
–
(2R,3R)-3-Methylornithinyl-N6-lysine + NAD+ + H2O <=> (2R,3R)-3-Methylglutamyl-5-semialdehyde-N6-lysine + NH3 + NADH + H+ 1.4.1
–
(RS)-nicotine + acceptor + H2O <=> 6-hydroxy-D-nicotine + reduced_acceptor 1.5.99.4 nicotine dehydrogenase
–
hydroquinone + O2 <=> 4-hydroxymuconic_acid_semialdehyde + H+ 1.13.11.66 hydroquinone 1,2-dioxygenase
–
succinyl-CoA + (R)-2-benzylsuccinate <=> succinate + (R)-2-benzylsuccinyl-CoA 2.8.3.15 succinyl-CoA:(R)-benzylsuccinate CoA-transferase
–
1,2,3,4-tetrachlorobenzene + O2 + NADPH + H+ <=> cis-Chlorobenzene_dihydrodiol + NADP+ 1.14.12
–
1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + NADH + H+ + O2 <=> cis-3-[2,2-Dichloro-1-(4-chlorophenyl)vinyl]-6-chlorocyclohexa-3,5-diene-1,2-diol + NAD+ 1.14.12
–
(S)-ureidoglycine + H2O <=> (S)-ureidoglycolate + NH3 3.5.3.26 (S)-ureidoglycine aminohydrolase
–

Visualization of the pathway